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New 3D micro-scaffold technology promotes reprogramming of stem cells into neurons

National Institutes of Health-funded scientists have developed a 3D micro-scaffold technology that promotes reprogramming of stem cells into neurons, and supports growth of neuronal connections capable of transmitting electrical signals.

18 Mar 2016

Surgeons successfully perform heart transplant at Baylor University Medical Center

A surgical team at Baylor University Medical Center at Dallas successfully performed a heart transplant on a patient they were keeping alive with a total artificial heart, a portable device that pumps blood throughout the body when both sides of the heart fail.

17 Mar 2016

Biomarkers may provide novel approaches to monitoring immunosuppressive therapy in organ transplant patients

Recently discovered biomarkers may provide valuable new approaches to monitoring immunosuppressive drug therapy in organ transplant recipients--with the potential for individualized therapy to reduce organ rejection and minimize side effects, according to a special article in the April issue of Therapeutic Drug Monitoring, official journal of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology.

17 Mar 2016

MUSC surgeon awarded $3.8 million grant to evaluate transplant drug

Seldom can one say $3.8 million is just the tip of the iceberg, but a newly awarded grant from Gilead Sciences, Inc. is just that. MUSC transplant surgeon Kenneth Chavin, M.D., Ph.D., says the true value of the multi-center drug trial is closer to $26 million, including $22 million in free drugs provided by the pharmaceutical company.

17 Mar 2016

Many kidney transplant patients may benefit from lower-than-standard dose of CNIs

The kidney is the most commonly transplanted organ in the United States, with more than 17,000 transplants performed each year. Following kidney transplant, patients are routinely placed on a regimen of immunosuppressant medications to prevent organ rejection, which often includes calcineurin inhibitors (CNIs) as the backbone medication of this regimen.

16 Mar 2016

New method to harvest stem cells reduces side effects for donors

Australian scientists have developed a new method for harvesting stem cells, which is less invasive and reduces side effects for donors.

16 Mar 2016

Researchers devise synthetic patch filled with insulin-producing beta cells to control blood sugar levels

For decades, researchers have tried to duplicate the function of beta cells, the tiny insulin-producing entities that don't work properly in patients with diabetes. Insulin injections provide painful and often imperfect substitutes. Transplants of normal beta cells carry the risk of rejection or side effects from immunosuppressive therapies.

16 Mar 2016

Heart failure drug has unexpected ability to block herpesvirus infection

Today, there is only one class of antiviral medicines against herpesviruses - a family of viruses that cause mononucleosis, herpes, and shingles, among other illnesses - meaning options for treating these infections are limited. If viruses become resistant to these frontline treatments, a growing problem particularly in clinical settings, there are no alternative drugs to serve as backup.

15 Mar 2016

Researchers find new innate immunity pathway that protects mammals from viral oncogenesis

Building upon earlier research, investigators at UT Southwestern Medical Center and their collaborators have identified a new innate immunity pathway that protects mammals from viral oncogenesis, the process by which viruses cause normal cells to become cancerous.

14 Mar 2016

Study shows gut microbes alter platelet function, heightens risk of heart attack and stroke

In a combination of both clinical studies of over 4,000 patients and animal model studies, Cleveland Clinic researchers have demonstrated -- for the first time -- that gut microbes alter platelet function and risk of blood clot-related illnesses like heart attack and stroke.

11 Mar 2016

PKM2 enzyme plays major role in early steps of wound healing

An enzyme involved in glucose metabolism in cells plays a major role in the early steps of wound healing, a finding that could lead to new therapeutic approaches for wound care, according to researchers at Georgia State University.

11 Mar 2016

Transplantation of periorbital tissues may be feasible alternative to protect vision in facial transplant patients

Transplantation of the periorbital tissues--the area surrounding the eyes--is a "technically feasible" alternative to protect a functioning eye in some patients being considered for facial transplant, according to a study in Plastic and Reconstructive Surgery--Global Open, the official open-access medical journal of the American Society of Plastic Surgeons.

11 Mar 2016

New procedure allows kidney transplants from incompatible donors

Researchers have found a way to stop patients rejecting kidneys that have come from incompatible donors, potentially slashing the waiting time for thousands of people in desperate need of the procedure.

10 Mar 2016

EAF celebrates first anniversary of Brussels Declaration on ADPKD, urges MEPs to unite for better patient care

On World Kidney Day, leading experts from the European ADPKD Forum today issue a collaborative letter to over 350 European decision makers (European Parliament, European Commission, Council representatives) celebrating the year one progress of the Brussels Declaration on ADPKD, while calling for urgent backing from policy makers to reduce the widespread inequalities and variations in care that remain.

10 Mar 2016

Pioneering progress on ADPKD: an interview with Tess Harris

ADPKD is a chronic, progressive and inherited kidney disease characterized by fluid-filled cysts that develop in the kidneys and other organs. It is the most common inherited kidney disease, and affects millions worldwide.

10 Mar 2016

Hematopoietic reprogramming can lead to differentiated blood products for cell-replacement therapy

Building upon previous work, researchers at the Icahn School of Medicine at Mount Sinai identified cells in the embryos of mice that are precursors to blood stem cells or hematopoietic stem/progenitor cells.

9 Mar 2016

Intervention program reduces caregiver distress during hospitalization of pediatric stem cell transplant patients

Research from an investigator at Rutgers Cancer Institute of New Jersey and colleagues from other facilities across the country, shows a social-cognitive intervention designed for parents of children undergoing a stem cell transplant had beneficial effects in reducing caregiver distress during the hospitalization period as compared with current best-practice psychosocial care.

9 Mar 2016

Modified protein appears to reverse liver fibrosis, cirrhosis in rats

A protein modified to increase the amount of time it circulates in the bloodstream appears to reverse liver fibrosis and cirrhosis in rats, according to results of a study led by Johns Hopkins researchers.

3 Mar 2016

Freestanding organ recovery facility for brain-dead donors increases organ transplant

Transplant surgeons report that obtaining organs from deceased organ donors costs much less and leads to a higher number of transplantable organs recovered when brain-dead donors are moved from the hospital to an independent, freestanding facility dedicated to organ recovery. Their study is published online as an "article in press" on the Journal of the American College of Surgeons website in advance of print publication later this year.

2 Mar 2016

First US uterus transplant is successful

The first US uterus transplant was performed this week by a team of surgeons at Cleveland Clinic, Cleveland, Ohio.

26 Feb 2016

Transplant News and Research

New 3D micro-scaffold technology promotes reprogramming of stem cells into neurons

Surgeons successfully perform heart transplant at Baylor University Medical Center

Biomarkers may provide novel approaches to monitoring immunosuppressive therapy in organ transplant patients

MUSC surgeon awarded $3.8 million grant to evaluate transplant drug

Many kidney transplant patients may benefit from lower-than-standard dose of CNIs

New method to harvest stem cells reduces side effects for donors

Researchers devise synthetic patch filled with insulin-producing beta cells to control blood sugar levels

Heart failure drug has unexpected ability to block herpesvirus infection

Researchers find new innate immunity pathway that protects mammals from viral oncogenesis

Study shows gut microbes alter platelet function, heightens risk of heart attack and stroke

PKM2 enzyme plays major role in early steps of wound healing

Transplantation of periorbital tissues may be feasible alternative to protect vision in facial transplant patients

New procedure allows kidney transplants from incompatible donors

EAF celebrates first anniversary of Brussels Declaration on ADPKD, urges MEPs to unite for better patient care

Pioneering progress on ADPKD: an interview with Tess Harris

Hematopoietic reprogramming can lead to differentiated blood products for cell-replacement therapy

Intervention program reduces caregiver distress during hospitalization of pediatric stem cell transplant patients

Modified protein appears to reverse liver fibrosis, cirrhosis in rats

Freestanding organ recovery facility for brain-dead donors increases organ transplant

First US uterus transplant is successful

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