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LORELEI trial: Treatment with alpha specific PI3K inhibitor reduces breast tumor size

Adding taselisib to letrozole before surgery significantly improved outcomes for patients with early breast cancer that was both estrogen receptor positive and HER2-negative (ER+/HER2-) according to results of the LORELEI trial, presented at the ESMO 2017 Congress in Madrid.

8 Sep 2017

New drug treatment linked to higher bladder compliance after spinal cord injury

Researchers have shown that compared to placebo, a drug treatment intended to prevent remodeling of the bladder wall and given within 48 hours after spinal cord injury (SCI) in dogs was associated with significantly higher bladder compliance.

7 Sep 2017

Cannabidiol appears to protect against long-term negative psychiatric effects of THC

A study reported Sept. 5 by neuroscientists at Indiana University finds that a non-psychoactive compound in cannabis called cannabidiol, or CBD, appears to protect against the long-term negative psychiatric effects of THC, the primary psychoactive ingredient in cannabis.

6 Sep 2017

Testing Service Members for Heat Related Illnesses Before Combat

It is common to think that combat deployment is the most dangerous part of being a warfighter, and in many ways this is correct. However, warfighters need to do many things before they are cleared to deploy to combat zones. Most cases of exertional heat illness (EHI) reported in the U.S. military occur during non-combat activities, such as training regimens, ruck marches, and operational exercises.

From Physitemp Instruments LLC 6 Sep 2017

Zika virus may one day be effective treatment for deadly brain cancer

While Zika virus causes devastating damage to the brains of developing fetuses, it one day may be an effective treatment for glioblastoma, a deadly form of brain cancer.

5 Sep 2017

Scientists identify and target specific brain area related to ‘hearing voices’ in schizophrenia

For the first time, scientists have precisely identified and targeted an area of the brain which is involved in "hearing voices", experienced by many patients with schizophrenia.

5 Sep 2017

Common heart disease medication may help treat pulmonary arterial hypertension

A team of Cleveland Clinic researchers found that a common heart disease medication, beta blockers, may help treat pulmonary arterial hypertension (PAH), a debilitating lung disease.

31 Aug 2017

New trial examines whether compound given before and after bypass surgery mitigates cognitive deficits

University of Arizona researchers are collaborating on a Phase 2 trial to determine whether a particular peptide administered before and after coronary bypass surgery mitigates or even reverses cognitive deficits thought to be connected to the procedure.

31 Aug 2017

Study finds transcranial direct-current stimulation to be less effective than anti-depressants

A new study questions the efficacy of treatments for depression based on stimulating brain areas with low-intensity electric current. The technique, known as transcranial direct-current stimulation (tDCS), was considered a promising alternative to treatment with antidepressant drugs.

31 Aug 2017

Study shows metabolic, cardiovascular consequences of untreated sleep apnea

Sleep apnea, left untreated for even a few days, can increase blood sugar and fat levels, stress hormones and blood pressure, according to a new study of sleeping subjects.

31 Aug 2017

CARBS study: Salacia extract provides appetite reduction, satiety and blood sugar management

In the recent CARBS (an acronym for Carbohydrate, Appetite Reduction, Blood Sugar and Satiety) study, researchers at Rutgers University observed that a proprietary salacia extract demonstrated appetite reduction, satiety and blood sugar management benefits.

30 Aug 2017

FDA grants accelerated approval to new treatment for children with Chagas disease

The U.S. Food and Drug Administration today granted accelerated approval to benznidazole for use in children ages 2 to 12 years old with Chagas disease. It is the first treatment approved in the United States for the treatment of Chagas disease.

29 Aug 2017

Low-dose hormone therapy may be effective in easing sleep issues for recently menopausal women

For many women, the side effects of menopause don't call it a day when they do. Between 40 and 60 percent of women in perimenopause and early menopause face issues with sleep because of this physical change. The majority also report hot flashes and night sweats, which can be disruptive to falling and staying asleep.

29 Aug 2017

First-in-class investigational drug lowers LDL cholesterol for up to one year, study finds

Inclisiran lowers low-density lipoprotein (LDL; "bad") cholesterol for up to one year in patients with high cardiovascular risk and elevated LDL cholesterol, according to late-breaking results from the ORION 1 trial presented today in a Hot Line LBCT Session at ESC Congress.

29 Aug 2017

Clinical benefit of LDL cholesterol lowering therapies could depend on reduction in apoB particles

The benefit of lowering low-density lipoprotein (LDL) cholesterol depends on how it is lowered, according to late-breaking results from a naturally randomised genetic trial presented today in a Hot Line - LBCT Session at ESC Congress1 and published in JAMA.

29 Aug 2017

Trial for PTSD treatment with MDMA-assisted psychotherapy receives FDA go-ahead

The United States Food and Drugs Administration FDA has granted permission for phase 3 trials in PTSD (Post traumatic stress disorder) patients using Ecstasy and psychotherapy in a treatment protocol called MDMA-Assisted Psychotherapy PTSD affects thousands of war veterans and other individuals and often leads to fatal outcomes of self-harm and suicides

28 Aug 2017

Reducing inflammation without lowering cholesterol significantly lowers rate of recurrent cardiovascular events

The researchers from Brigham and Women's Hospital this week have come up with a new study which shows that reducing the inflammation among patients who have already had a heart attack before could prevent the risk of getting more cardiovascular events. The study is published in the latest issue of the New England Journal of Medicine.

28 Aug 2017

Lung experts test nicotine patches as potential treatment for sarcoidosis

Doctors believe there is some good to be found in nicotine, the highly addictive drug in tobacco products. Lung experts at The Ohio State University Wexner Medical Center are testing whether nicotine can help people with a chronic inflammatory lung disease called sarcoidosis.

28 Aug 2017

Anti-inflammatory therapy reduces incidence of lung cancer

In most clinical trials for cancer therapy, investigators test treatments in patients with advanced disease. But a recent cardiovascular secondary prevention study has given researchers a unique opportunity: to explore the effectiveness of giving a drug to patients before cancer emerges.

28 Aug 2017

Drug reduces inflammation to lower cardiovascular disease and lung cancer risk

The IL-1β inhibitor canakinumab lowers the risk of cardiovascular disease and lung cancer risk by reducing inflammation, according to late-breaking results from the CANTOS trial presented today in a Hot Line - LBT Session at ESC Congress1 and published in the NEJM.

28 Aug 2017

Placebo News and Research

LORELEI trial: Treatment with alpha specific PI3K inhibitor reduces breast tumor size

New drug treatment linked to higher bladder compliance after spinal cord injury

Cannabidiol appears to protect against long-term negative psychiatric effects of THC

Testing Service Members for Heat Related Illnesses Before Combat

Zika virus may one day be effective treatment for deadly brain cancer

Scientists identify and target specific brain area related to ‘hearing voices’ in schizophrenia

Common heart disease medication may help treat pulmonary arterial hypertension

New trial examines whether compound given before and after bypass surgery mitigates cognitive deficits

Study finds transcranial direct-current stimulation to be less effective than anti-depressants

Study shows metabolic, cardiovascular consequences of untreated sleep apnea

CARBS study: Salacia extract provides appetite reduction, satiety and blood sugar management

FDA grants accelerated approval to new treatment for children with Chagas disease

Low-dose hormone therapy may be effective in easing sleep issues for recently menopausal women

First-in-class investigational drug lowers LDL cholesterol for up to one year, study finds

Clinical benefit of LDL cholesterol lowering therapies could depend on reduction in apoB particles

Trial for PTSD treatment with MDMA-assisted psychotherapy receives FDA go-ahead

Reducing inflammation without lowering cholesterol significantly lowers rate of recurrent cardiovascular events

Lung experts test nicotine patches as potential treatment for sarcoidosis

Anti-inflammatory therapy reduces incidence of lung cancer

Drug reduces inflammation to lower cardiovascular disease and lung cancer risk

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