Preclinical News and Research

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Study examines feasibility of using Decoded Neurofeedback to control pain

Chronic pain is one of the most important health priorities of the 21st century, with a socioeconomic cost that may far exceed other most other medical problems.

13 Aug 2020

Researchers develop new strategies to treat osteoporosis

A research team from the National University of Singapore (NUS) has identified a new avenue to maintain bone health while reducing bone resorption.

12 Aug 2020

Purdue University startup receives NIH grant to advance Alzheimer's research

A $2 million grant from the National Institute on Aging at the National Institutes of Health to Neurodon, a Purdue University-affiliated startup, will help fast-track molecules that could improve memory and reduce Alzheimer's disease neurodegeneration.

12 Aug 2020

New technology could serve as more reliable model of amyotrophic lateral sclerosis

A new study published today demonstrates that a technology developed at the University of Central Florida could serve as a more reliable clinically-based model of amyotrophic lateral sclerosis (ALS) and a better screening tool for novel therapies than currently use preclinical models.

12 Aug 2020

1st human data for Sinovac's SARS-CoV-2 CoronaVac vaccine is out

A group of Chinese researchers recently conducted a phase 2 clinical trial to further evaluate the immunogenicity and safety of SARS-CoV-2 inactivated vaccine known as CoronaVac. The results are currently available on the medRxiv preprint server and demonstrate that the vaccine is well tolerated and without any notable dose-related safety concerns, which opens the door for phase 3 clinical trial.

11 Aug 2020

Inhaled delivery of a potent neutralizing nanobody effective against SARS-CoV-2

A recent study by researchers from China, available on the bioRxiv preprint server, shows how stable neutralizing nanobody Nb11-59 might be a promising prophylactic and therapeutic molecule against coronavirus disease (COVID-19) – especially if administered via the inhalatory route.

11 Aug 2020

Study may help optimize materials used in implants, enhance their safety

Using highly complex analytical techniques, a group of researchers from Charité - Universitätsmedizin Berlin were able to observe in detail how different metals are released from joint implants and accumulate in the surrounding bone tissue.

11 Aug 2020

Only half of pregnant women worldwide get treatment for preventable Rh disease

Only half of pregnant women worldwide who need a treatment developed over 50 years ago to prevent Rh disease--an often-fatal condition in fetuses and newborns that is now exceedingly rare in the United States and Western Europe--actually receive it, finds a study led by researchers at Vagelos College of Physicians and Surgeons at Columbia University Irving Medical Center.

10 Aug 2020

Vaccine 'nationalism' will slow coronavirus fight if poor countries are left exposed

As the coronavirus vaccine race charges on, many of the investigational candidate vaccines are nearing the final stages of human trials. The results of these trials will determine if they will be granted the green light to manufacture and distribute the vaccine to countries across the globe.

10 Aug 2020

Nanomedicine-based strategy enhances anti-PD1 therapy to eradicate PTEN-negative GBM

A nanomedicine-based strategy for chemo-immunotherapy (CIT) of glioblastoma (GBM), which has the worst prognosis among brain tumors, was successfully developed.

7 Aug 2020

Powerful treatment for IPF stops dangerous scar formation in mouse lungs

A pre-clinical study led by scientists at Cincinnati Children's demonstrates that in mice the drug barasertib reverses the activation of fibroblasts that cause dangerous scar tissue to build up in the lungs of people with idiopathic pulmonary fibrosis (IPF).

6 Aug 2020

New alpha-radioimmunotherapy for multiple myeloma shows promise in preclinical study

A new alpha-radioimmunotherapy, 212Pb-anti-CD38, has proven effective in preventing tumor growth and increasing survival in multiple myeloma tumor-bearing mice, according to new research published in the July issue of the Journal of Nuclear Medicine. Given the long half-life, central production and worldwide distribution of 212Pb-anti-CD38, researchers have determined that the α-radioimmunotherapy is not only effective but also clinically feasible as a multiple myeloma treatment.

6 Aug 2020

Sanford Burnham Prebys receives NIH grant to identify new therapies for mental disorders

Sanford Burnham Prebys Medical Discovery Institute has been awarded a $4.5 million grant from the National Institutes of Health (NIH) to identify new therapies for mental health disorders.

6 Aug 2020

Carefully engineered spike protein can help develop COVID-19 vaccine

The experimental vaccine against SARS-CoV-2 that was the first to enter human trials in the United States has been shown to elicit neutralizing antibodies and a helpful T-cell response with the aid of a carefully engineered spike protein that mimics the infection-spreading part of the virus.

6 Aug 2020

Cats susceptible to and potential reservoirs for novel coronavirus

The study published on the preprint server bioRxiv in August 2020 shows that this is indeed taking place, with pet cats being infected and passing on the infection to contacts. It also offers the chance to see how the disease progresses in a susceptible host.

6 Aug 2020

NIH-Moderna investigational vaccine protects mice from infection with SARS-CoV-2

The investigational vaccine known as mRNA-1273 protected mice from infection with SARS-CoV-2, the virus that causes COVID-19, according to research published today in Nature.

5 Aug 2020

European Commission approves first drug for hepatitis D

What started off as basic research 25 years ago has now lead to a successfully approved drug: The entry blocker bulevirtide (brand name Hepcludex, formerly known as Myrcludex B), jointly developed by researchers from Heidelberg University Hospital (UKHD) and the Medical Faculty of Heidelberg, the DZIF and other partners, has now been approved by the European Commission.

5 Aug 2020

Preclinical News and Research

Study examines feasibility of using Decoded Neurofeedback to control pain

Researchers develop new strategies to treat osteoporosis

Purdue University startup receives NIH grant to advance Alzheimer's research

New technology could serve as more reliable model of amyotrophic lateral sclerosis

1st human data for Sinovac's SARS-CoV-2 CoronaVac vaccine is out

Inhaled delivery of a potent neutralizing nanobody effective against SARS-CoV-2

Study may help optimize materials used in implants, enhance their safety

Only half of pregnant women worldwide get treatment for preventable Rh disease

Vaccine 'nationalism' will slow coronavirus fight if poor countries are left exposed

Nanomedicine-based strategy enhances anti-PD1 therapy to eradicate PTEN-negative GBM

Powerful treatment for IPF stops dangerous scar formation in mouse lungs

New alpha-radioimmunotherapy for multiple myeloma shows promise in preclinical study

Sanford Burnham Prebys receives NIH grant to identify new therapies for mental disorders

Carefully engineered spike protein can help develop COVID-19 vaccine

Cats susceptible to and potential reservoirs for novel coronavirus

NIH-Moderna investigational vaccine protects mice from infection with SARS-CoV-2

European Commission approves first drug for hepatitis D

New research project receives federal funding to expand treatment options for sickle cell patients

Scientists develop new models to study molecular characteristics of lung and pancreatic cancers

New computational model can help determine drug viability

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