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Mollusc-derived compounds potential medicines for COVID-19 and other respiratory diseases

A research team has reviewed the existing literature on compounds derived from molluscs used for treating respiratory diseases.

30 Nov 2020

Mild electrical stimulation with heat shock exerts protective effect against nephrotic syndrome

A research team from Kumamoto University in Japan has found that the combination of weak pulsed electrical current and heat exerts anti-inflammatory and anti-fibrotic effects in the kidneys, as well as a protective effect against nephrotic syndrome (NS) by inhibiting apoptosis (cell death) of kidney cells.

30 Nov 2020

Are SARS-CoV-2 protease inhibitors effective antivirals in treating COVID-19?

Many antiviral development studies have focused on the possibility of inhibiting the main viral protease (Mpro), and papain-like protease (PLpro), given their central role in viral replication. A new study draws attention to the high odds that these may not have anti-infective activity because of the redundant pathways present in human host cells.

30 Nov 2020

Resveratrol shows potential as SARS-CoV-2 antiviral, study finds

A recent study reveals that resveratrol, a phenolic compound produced by spermatophytes, can inhibit the viral replication SARS-CoV-2.

27 Nov 2020

Ipom-F inhibits SARS-CoV-2 infection in vitro

An international team of researchers showed the small molecule inhibitor, ipomoeassin F (Ipom-F), blocks the translocation/insertion of the three protein targets for SARS-CoV-2 infection.

27 Nov 2020

Researchers develop synthetic defective SARS-CoV-2 genome that inhibits viral replication

A shorter genome comprising only a part of the SARS-CoV-2's RNA genome competes with the normal virus for growth and can potentially prevent viral replication.

26 Nov 2020

Phycobilins found to inhibit SARS-CoV-2 enzymes in vitro

Researchers have released an interesting new study that describes the broad-spectrum of antiviral activity that phycobilins can have. Phycobilins, which are bioactive plant compounds, were found to inhibit two coronavirus enzymes.

26 Nov 2020

Researchers develop first plant-based gel to support organoid growth for biomedical applications

Monash University researchers have created the world's first bioactive plant-based nanocellulose hydrogel to support organoid growth and help significantly reduce the costs of studies into cancer and COVID-19.

25 Nov 2020

Study unravels the immunogenicity of ferroptotic cancer cells

The interdisciplinary team of scientists from three different countries (Belgium, Italy, and Russia) under the leadership of Prof. Dr. Dmitri V. Krysko (Ghent University, Belgium) unravels the immunogenicity of ferroptotic cancer cells.

25 Nov 2020

SARS-CoV-2 spike protein antibodies can persist up to 200 days after symptom onset

Researchers report SARS-CoV-2 antibodies to the spike protein (S protein) can persist 200 days after symptom onset, but that antibodies to the nucleoprotein (N protein) can reduce much more rapidly.

25 Nov 2020

SARS-CoV-2 versus Zika: Comparing and contrasting the flow of research

An interesting study published on the preprint server medRxiv in November 2020, dealing not with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is the cause of the COVID-19 pandemic, but with the publications that have appeared as a consequence of the outbreak, comparing them with the similar trove of publications that followed the Zika virus outbreak in 2016.

25 Nov 2020

BCG vaccination appears to trigger cross-reactive SARS-CoV-2-specific T cell response

Recently, researchers from the Monash University and Monash Medical Centre, Clayton, Victoria, Australia, investigated whether peptide sensitization using BCG can produce cross-reactive T cells specific to SARS-CoV-2. Their study is published on the preprint server, medRxiv.

24 Nov 2020

Mefloquine shows potential as anti-SARS-CoV-2 drug

A team of scientists from Japan has identified the approved anti-material drug, mefloquine, as a potential candidate to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Specifically, mefloquine has been shown to prevent the entry of SARS-CoV-2 into host cells and reduce the viral load in vitro.

24 Nov 2020

Researchers recommend antibody cocktail to tackle SARS-CoV-2 mutations

A new study released on the medRxiv* preprint server indicates that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent responsible for the current coronavirus disease 2019 (COVID-19) pandemic – is developing multiple mutations that affect neutralization by antibodies.

24 Nov 2020

Greensboro North Carolina Company’s Dedication to Ensuring Laboratories have COVID-19 Supplies Now Offers One-Stop-Shop for PCR Instruments, Extraction Systems and Kits, POC COVID-19 Test Kits, and Supplies.

GREENSBORO, NC — (November 20, 2020) – Greensboro-based, Carolina Liquid Chemistries Corp. (CLC) has been tirelessly working since the beginning of the COVID-19 outbreak to provide high-quality testing kits and instruments to healthcare providers and laboratories as quickly as possible.

From Carolina Liquid Chemistries Corp. 23 Nov 2020

Researchers develop recombinant SARS-CoV-2 model to aid vaccine and antiviral research

Researchers have developed a fluorescent reporter gene-bearing recombinant form of SARS-CoV-2, which is capable of replication.

23 Nov 2020

Pomegranate peel extract shows potential as inhibitor of SARS-CoV-2 virus

Researchers led by first author Relja Suručić from the Department of Pharmacognosy, Faculty of Medicine, University of Banja Luka, Banja Luka, Bosnia and Herzegovina, have studied the use of pomegranate peel extracts in preventing infections with SARS-CoV-2.

22 Nov 2020

Sage and perilla herbal teas could help to prevent or treat COVID-19

Researchers in Germany have conducted a study demonstrating the potential antiviral effects of commonly consumed herbal teas on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the pathogen that causes coronavirus disease 2019 (COVID-19).

22 Nov 2020

Chemists discover effective inhibitors to block SARS-CoV-2

Some viruses can get inside cells via a mechanism that involves sulfur organic molecules. Chemists at UNIGE have discovered effective inhibitors and blocked the uptake of SARS-CoV-2.

20 Nov 2020

Lonza provides expansive selection of high-resolution HLA-typed primary cells to boost drug development

Lonza has announced that it now provides an expansive selection of high-resolution Human Leukocyte Antigen (HLA)-typed primary cells spanning all major cell and tissue types.

From Lonza 20 Nov 2020

in vitro News and Research

Mollusc-derived compounds potential medicines for COVID-19 and other respiratory diseases

Mild electrical stimulation with heat shock exerts protective effect against nephrotic syndrome

Are SARS-CoV-2 protease inhibitors effective antivirals in treating COVID-19?

Resveratrol shows potential as SARS-CoV-2 antiviral, study finds

Ipom-F inhibits SARS-CoV-2 infection in vitro

Researchers develop synthetic defective SARS-CoV-2 genome that inhibits viral replication

Phycobilins found to inhibit SARS-CoV-2 enzymes in vitro

Researchers develop first plant-based gel to support organoid growth for biomedical applications

Study unravels the immunogenicity of ferroptotic cancer cells

SARS-CoV-2 spike protein antibodies can persist up to 200 days after symptom onset

SARS-CoV-2 versus Zika: Comparing and contrasting the flow of research

BCG vaccination appears to trigger cross-reactive SARS-CoV-2-specific T cell response

Mefloquine shows potential as anti-SARS-CoV-2 drug

Researchers recommend antibody cocktail to tackle SARS-CoV-2 mutations

Greensboro North Carolina Company’s Dedication to Ensuring Laboratories have COVID-19 Supplies Now Offers One-Stop-Shop for PCR Instruments, Extraction Systems and Kits, POC COVID-19 Test Kits, and Supplies.

Researchers develop recombinant SARS-CoV-2 model to aid vaccine and antiviral research

Pomegranate peel extract shows potential as inhibitor of SARS-CoV-2 virus

Sage and perilla herbal teas could help to prevent or treat COVID-19

Chemists discover effective inhibitors to block SARS-CoV-2

Lonza provides expansive selection of high-resolution HLA-typed primary cells to boost drug development

eBook: Using iPSCs models for human disease research and drug discovery eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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