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New approach to kill specific bacteria could be alternative to antibiotics

A new approach to killing C. difficile that silences key bacterial genes while sparing other bacteria may provide a new way to treat the most common hospital-acquired bacterial infection in the United States, according to researchers.

7 Jun 2018

Researchers develop new sensor to detect bad breath

Ever wish you could do a quick "breath check" before an important meeting or a big date? Now researchers, reporting in ACS' journal Analytical Chemistry, have developed a sensor that detects tiny amounts of hydrogen sulfide gas, the compound responsible for bad breath, in human exhalations.

6 Jun 2018

Opdivo plus low-dose Yervoy shows promising results in treating renal cell carcinoma patients

Bristol-Myers Squibb Company today announced patient-reported outcomes data from the Phase 3 CheckMate -214 trial in intermediate- and poor-risk patients with advanced renal cell carcinoma treated with the Immuno-Oncology combination Opdivo plus low-dose Yervoy versus sunitinib over a two-year follow-up period.

1 Jun 2018

Salk researchers discover molecule that destroys key HIV protein

One of the many challenges in treating HIV is that the virus can lie dormant in cells, quietly evading immune detection until it suddenly roars to life without warning and begins replicating furiously.

1 Jun 2018

Researchers reveal potent new mechanism of action for treatment of IBD

Professor Akiyoshi Fukamizu's research group of Life Science Center for Survival Dynamics, University of Tsukuba, Eisai Co., Ltd. and its gastrointestinal business subsidiary EA Pharma Co., Ltd. have revealed a mechanism in which an analogue (ER-464195-01) of Eisai's in-house discovered E6007 inhibits integrin activation by dissociating interaction between calreticulin (CRT) and integrin α 4 (ITGA4), suppressing adhesion and infiltration of leukocytes overall.

25 May 2018

Immune cells promote lung cancer metastases by forming clots in tumors, study finds

University of North Carolina Lineberger Comprehensive Cancer Center researchers have found that by helping to form clots within tumors, immune cells that flock to a particular type of lung cancer are actually building a foundation for the tumor to spread within the body.

25 May 2018

$2.3 million NIH grant to support new project on oxytocin neurons and social behavior

A team of Penn State researchers is planning to create a new map of the brain that will establish a neural circuit diagram of oxytocin, a compound often associated with affection and emotional behavior. Researchers hope the map will give them insight into how oxytocin in the brain drives social behavior.

24 May 2018

Celgene to share new and updated data around novel hematological therapies

Celgene Corporation today announced that data from a broad range of early and late stage studies evaluating Celgene investigational agents and investigational uses of marketed products will be presented at the 23rd European Hematology Association annual meeting in Stockholm, Sweden, from June 14-17, 2018.

22 May 2018

Combination of vascular risk and brain amyloid levels may accelerate age-related cognitive decline

Risk factors for heart disease and stroke appear to hasten the risk of cognitive decline in normal older individuals with evidence of very early Alzheimer's-disease-associated changes in the brain.

22 May 2018

Researchers discover new disease mechanism in chronic tobacco smokers

Research published in the journal Clinical Science suggests that an immune signaling protein called interleukin-26 is increased among chronic smokers with lung disease and this involvement reveals disease mechanisms of interest for developing more effective therapy for these hard-to-treat patients.

21 May 2018

Antibacterial substance found in toothpaste may fight against life-threatening lung disease

Michigan State University researchers have found that when triclosan, a substance that reduces or prevents bacteria from growing, is combined with an antibiotic called tobramycin, it kills the cells that protect the CF bacteria, known as Pseudomonas aeruginosa, by up to 99.9 percent.

17 May 2018

Study finds molecular handle that chikungunya virus uses to enter into cells and cause arthritis

Chikungunya virus is a growing threat to the United States and other regions of the world as the mosquito that carries the virus expands its reach. Telltale symptoms of chikungunya infection are fever and joint pain that last about a week.

17 May 2018

Volatile biomarkers could help detect acute and asymptomatic malaria infections

Malaria is still a deadly disease in tropical and subtropical regions. Every year the disease infects more than 200 million people worldwide, claiming several hundred thousand victims.

15 May 2018

Researchers to take 'unprecedented look' into protein behind hypertension, epilepsy, and overactive bladder

The seemingly unrelated conditions of hypertension, epilepsy and overactive bladder may be linked by electrical activity in a protein long studied by a biomedical engineer at Washington University in St. Louis.

15 May 2018

New cancer treatment approach targets specific sugar receptors

In the treatment of cancer, there are still several limitations. Especially the delivery of sufficient amounts of active chemotherapeutic drug is difficult.

15 May 2018

Researchers use spheroids to screen for potential cancer drugs

Researchers from The Scripps Research Institute have reported a new and more effective way of screening for potential cancer drugs.

14 May 2018

ICON and DuPage Medical Group announce clinical research partnership

ICON plc, a global provider of drug development and commercialization solutions and services, today announced that PMG Research, Inc., part of ICON Site and Patient Recruitment, and DuPage Medical Group of Chicago, Illinois have finalized a Master Agreement formalizing a clinical research partnership.

14 May 2018

First, marijuana. Are magic mushrooms next?

In Oregon and Denver, where marijuana is legal for recreational use, activists are now pushing toward a psychedelic frontier: "magic mushrooms."

14 May 2018

Enhancing the effects of vitamin D to curb type 2 diabetes

More than 27 million people in the United States are living with type 2 diabetes, according to the Centers for Disease Control and Prevention. As the population ages and a growing percentage of people become overweight or obese, that number is expected to increase.

10 May 2018

ICON announces results of new survey that examines key challenge of R&D efficiency

ICON plc, a global provider of drug development solutions and services to the pharmaceutical, biotechnology and medical device industries, today announced the results from a new survey of pharmaceutical executives and professionals by ICON and Pharma Intelligence, which examines the key challenge of declining research and development efficiency

9 May 2018

Compound News and Research

New approach to kill specific bacteria could be alternative to antibiotics

Researchers develop new sensor to detect bad breath

Opdivo plus low-dose Yervoy shows promising results in treating renal cell carcinoma patients

Salk researchers discover molecule that destroys key HIV protein

Researchers reveal potent new mechanism of action for treatment of IBD

Immune cells promote lung cancer metastases by forming clots in tumors, study finds

$2.3 million NIH grant to support new project on oxytocin neurons and social behavior

Celgene to share new and updated data around novel hematological therapies

Combination of vascular risk and brain amyloid levels may accelerate age-related cognitive decline

Researchers discover new disease mechanism in chronic tobacco smokers

Antibacterial substance found in toothpaste may fight against life-threatening lung disease

Study finds molecular handle that chikungunya virus uses to enter into cells and cause arthritis

Volatile biomarkers could help detect acute and asymptomatic malaria infections

Researchers to take 'unprecedented look' into protein behind hypertension, epilepsy, and overactive bladder

New cancer treatment approach targets specific sugar receptors

Researchers use spheroids to screen for potential cancer drugs

ICON and DuPage Medical Group announce clinical research partnership

First, marijuana. Are magic mushrooms next?

Enhancing the effects of vitamin D to curb type 2 diabetes

ICON announces results of new survey that examines key challenge of R&D efficiency

Enhancing confidence in chemical ionization spectrometry data eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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