Malignant News and Research

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Selective blocking of HDAC11 inhibitor would act exclusively on tumor cells

Several substances inhibiting so-called HDAC enzymes have been studied in trials searching for new anti-cancer drugs in recent years. "Trials have shown that HDAC inhibitors are very effective in arresting growth of cultured cancer cells. But apart from a very rare type of lymphoma, these drugs unfortunately do not clinically affect malignant tumors," says Prof. Dr. Olaf Witt, who heads a research department at DKFZ and is pediatrician at the Center for Child and Adolescent Medicine of Heidelberg University Hospital.

6 Nov 2012

First study to measure minute changes in breast tumor connective tissue fibers

Using advanced microscopes equipped with tissue-penetrating laser light, cancer imaging experts at Johns Hopkins have developed a promising, new way to accurately analyze the distinctive patterns of ultra-thin collagen fibers in breast tumor tissue samples and to help tell if the cancer has spread.

3 Nov 2012

Bristol-Myers Squibb welcomes decision by NICE to recommend Yervoy for advanced melanoma

Today, Bristol-Myers Squibb is pleased to welcome the decision by The National Institute for Health and Clinical Excellence (NICE) to recommend Yervoy (ipilimumab) for the treatment of previously-treated advanced (unresectable or metastatic) melanoma within the Final Appraisal Determination (FAD).

3 Nov 2012

Imatinib mesylate effectively treats children with neurofibromatosis type 1 tumors

Physician-researchers at Indiana University School of Medicine have reported the first effective therapy for a class of previously untreatable and potentially life-threatening tumors often found in children.

2 Nov 2012

Malarial drug shows promise in stopping breast cancer

A malarial drug is showing promise in stopping breast cancer before it starts, Mason researchers are discovering during a clinical trial.

2 Nov 2012

Biomarker discovery offers hope for lung cancer blood test

Blood levels of a variant form of the nuclear matrix protein Ciz1 are significantly higher in individuals with early- and late-stage lung cancer than in lung cancer-free individuals, researchers report.

31 Oct 2012

Blocking RSK protein activity could improve treatment of skin cancers

Blocking the action of a particular protein in our skin could improve the treatment of skin cancers, according to a study published in Oncogene yesterday by Philippe Roux, a researcher at the University of Montreal's Institute for Research in Immunology and Cancer (IRIC).

31 Oct 2012

Sequana Medical announces CE mark approval of alfapump for patients with malignant ascites

Sequana Medical is pleased to announce that it has received CE mark approval for use of its alfapump system in patients with ascites caused by cancer (malignant ascites).

30 Oct 2012

Researchers decode software instructions that drive 3 different forms of acute lymphoblastic leukemia

30 Oct 2012

Low-dose radiation PCT developed for breast screening

US researchers have developed a high-resolution, low-dose phase contrast X-ray tomography for diagnosis of breast cancers that delivers a 74% reduced radiation dose compared with conventional PCT.

29 Oct 2012

Scientists decode epigenetic programming of three virulent forms of acute lymphoblastic leukemia

A team of national and international researchers, led by Weill Cornell Medical College scientists, have decoded the key "software" instructions that drive three of the most virulent forms of acute lymphoblastic leukemia (ALL). They discovered ALL's "software" is encoded with epigenetic marks, chemical modifications of DNA and surrounding proteins, allowing the research team to identify new potential biomarkers and therapeutic targets.

29 Oct 2012

Living examples of hope and determination against cancer

Their battle with cancer is not the only thing that unites the Labrada sisters of Houston who are now cancer-free and strong advocates for women taking charge of their bodies.

29 Oct 2012

Researchers identify genes linked to serous endometrial cancer

Researchers have identified several genes that are linked to one of the most lethal forms of uterine cancer, serous endometrial cancer.

29 Oct 2012

Up to 10% of acute lung injuries may be drug-related

A population-based study has found that drug-induced acute lung injury accounts for around 9.5% of all acute lung injury cases.

23 Oct 2012

Breast cancer spread dependent on both environment and genetic changes

A new study from Johns Hopkins researchers suggests that the lethal spread of breast cancer is as dependent on a tumor’s protein-rich environment as on genetic changes inside tumor cells.

23 Oct 2012

Glioblastoma multiforme can originate from cortical neurons

Scientists have long believed that glioblastoma multiforme (GBM), the most aggressive type of primary brain tumor, begins in glial cells that make up supportive tissue in the brain or in neural stem cells. In a paper published October 18 in Science Express, however, researchers at the Salk Institute for Biological Studies have found that the tumors can originate from other types of differentiated cells in the nervous system, including cortical neurons.

23 Oct 2012

Malignant melanoma cases increase in Sweden

Malignant melanoma is as much as 35% more common among people who live in Gothenburg and the region's coastal municipalities than those who live inland. Researchers at Sahlgrenska Academy, University of Gothenburg, Sweden, have found that the number of malignant melanoma cases in the Västra Götaland region has quadrupled since 1970.

22 Oct 2012

Ultrasound superior to mammography in evaluating women with breast cancer symptoms

The largest analysis to date comparing ultrasound and mammography to evaluate women ages 30 to 39 with symptoms of possible breast cancer concludes that ultrasound is a superior diagnostic tool and that U.S. clinical practice guidelines, which currently recommend mammography as the first evaluation in these women, should be reconsidered.

22 Oct 2012

New diagnostic tool identifies metastatic ability of breast cancer cells

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) and The Institute of Photonic Sciences (ICFO) have collaborated on the development of a diagnostic tool that identifies the metastatic ability of breast cancer cells.

20 Oct 2012

New video on how to handle Malignant Hyperthermia crisis now available from MHAUS

New video on how to handle a Malignant Hyperthermia crisis is now available from the Malignant Hyperthermia Association of the United States.

20 Oct 2012

Malignant News and Research

Selective blocking of HDAC11 inhibitor would act exclusively on tumor cells

First study to measure minute changes in breast tumor connective tissue fibers

Bristol-Myers Squibb welcomes decision by NICE to recommend Yervoy for advanced melanoma

Imatinib mesylate effectively treats children with neurofibromatosis type 1 tumors

Malarial drug shows promise in stopping breast cancer

Biomarker discovery offers hope for lung cancer blood test

Blocking RSK protein activity could improve treatment of skin cancers

Sequana Medical announces CE mark approval of alfapump for patients with malignant ascites

Researchers decode software instructions that drive 3 different forms of acute lymphoblastic leukemia

Low-dose radiation PCT developed for breast screening

Scientists decode epigenetic programming of three virulent forms of acute lymphoblastic leukemia

Living examples of hope and determination against cancer

Researchers identify genes linked to serous endometrial cancer

Up to 10% of acute lung injuries may be drug-related

Breast cancer spread dependent on both environment and genetic changes

Glioblastoma multiforme can originate from cortical neurons

Malignant melanoma cases increase in Sweden

Ultrasound superior to mammography in evaluating women with breast cancer symptoms

New diagnostic tool identifies metastatic ability of breast cancer cells

New video on how to handle Malignant Hyperthermia crisis now available from MHAUS

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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