Preclinical News and Research

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Regeneron antibody cocktail shows promise as potential COVID-19 treatment

Researchers in the U.S. have shown both preventive and treatment effects of an antibody cocktail in animal models of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - the agent that causes coronavirus disease 2019 (COVID-19).

4 Aug 2020

Five alternative methods of SARS-CoV-2 suppression

The current pandemic has proved to be challenging to control without stringent and comprehensive non-pharmacological interventions (NPIs), relying mostly on isolation and contact tracing of cases, along with social distancing. However, strategies like these have a huge human cost in terms of restriction of social interactions, resulting in depressive tendencies, disruption of economic activity, and loss of educational resources.

3 Aug 2020

Immune system's oldest branches may underpin COVID severity

One of the immune system's oldest branches, called complement, may be influencing the severity of COVID disease, according to a new study from researchers at Columbia University Irving Medical Center.

3 Aug 2020

The race to a coronavirus vaccine

As the number of coronavirus disease (COVID-19) cases skyrocket to a staggering 18 million, the race to attain vaccine approval is on. More than a hundred candidate vaccines are being developed and tested to prevent infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Now, many vaccine candidates are undergoing human stage 2 and 3 trials to prove their efficacy and safety.

2 Aug 2020

Touchlight, Cancer Research UK and University of Southampton team up to develop DNA cancer vaccine

Cancer Research UK, the University of Southampton and Touchlight Genetics, a London based biotechnology company, today (Wednesday) announce a new clinical development partnership to progress a therapeutic DNA vaccine, TGL-100, into an early phase clinical trial targeting head and neck squamous cell carcinoma.

31 Jul 2020

Investigational drug shows promising results for treating HNSCC tumors

Head and neck cancer is one of the leading causes of cancer-related deaths worldwide, and squamous cell carcinomas (HNSCC) account for the majority of these cases.

31 Jul 2020

Study reports highly potent anti-SARS-CoV-2 compounds

A new study published on the preprint server bioRxiv in July 2020 reports that a series of potent enzyme inhibitors have been designed to suppress severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication by interfering with one of the primary viral proteases.

30 Jul 2020

Researchers launch randomized, placebo-controlled clinical trial of pulmozyme in COVID-19 patients

Researchers at Boston Children's Hospital and Brigham and Women's Hospital have launched a randomized, placebo-controlled clinical trial of dornase alfa (Pulmozyme) in patients with severe COVID-19 pneumonia and respiratory failure requiring mechanical ventilation.

29 Jul 2020

Simple blood test may be a great advance for people with and at risk for Alzheimer's

A simple blood test for Alzheimer's would be a great advance for individuals with - and at risk for - the disease, families, doctors and researchers.

28 Jul 2020

A new cell-based gene therapy approach to better treat patients with hemophilia A

In a new study from the Wake Forest Institute for Regenerative Medicine researchers have developed an optimized cellular platform for delivering Factor 8 to better treat patients with hemophilia A.

28 Jul 2020

Discovery could pave way for a blood test to diagnose Alzheimer's before symptoms appear

Two decades or more before symptoms arise, plaques of a sticky protein called amyloid begin forming in the brains of people later diagnosed with Alzheimer's disease.

28 Jul 2020

Novel drug candidate offers a major advance in the treatment for diabetes

The University of Alabama at Birmingham and Southern Research have discovered a new drug candidate that offers a major advance in the treatment for diabetes.

28 Jul 2020

Two-step targeting strategy can increase clinical translation of nanoparticle-based therapies

Therapy-loaded nanoparticles may be directed to the brain by functionalization with ligands targeting BBB-associated proteins.

27 Jul 2020

Curi Bio Acquires Dana Solutions

Curi Bio has acquired Dana Solutions, a pioneer in the application of artificial intelligence and machine learning to in vitro cell-based assays.

From Curi Bio 27 Jul 2020

Study finds a sharp decline in heart transplants during the pandemic

The number of heart transplants in the United States declined sharply during the beginning of the pandemic, even in areas of the country with few COVID-19 cases at the time, according to an analysis by researchers at Columbia University Irving Medical Center.

24 Jul 2020

Experimental mRNA-based COVID-19 vaccine elicits protective immune responses in animals

An experimental messenger RNA (mRNA)-based vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicits protective immune responses in mice and non-human primates, researchers report on July 23rd in the journal Cell.

24 Jul 2020

Researchers discover new method to treat herpes viruses

Researchers at Lund University in Sweden have discovered a new method to treat human herpes viruses. The new broad-spectrum method targets physical properties in the genome of the virus rather than viral proteins, which have previously been targeted.

24 Jul 2020

Boehringer Ingelheim and Biognosys join forces on applying quantitative proteomics tools in drug discovery

Biognosys announced today that it started working together with Boehringer Ingelheim.

From Biognosys 24 Jul 2020

Study shows inert drug ingredients could lead to unanticipated side effects

Some supposedly inert ingredients in common drugs -- such as dyes and preservatives -- may potentially be biologically active and could lead to unanticipated side effects, according to a preliminary new study by researchers from the UC San Francisco School of Pharmacy and the Novartis Institutes for BioMedical Research (NIBR).

24 Jul 2020

Hollings Cancer Center researcher receives NCI grants for cancer immunotherapy studies

Hollings Cancer Center researcher Jessica Thaxton, Ph.D., is the recipient of two grants totaling $3.4 million from the National Cancer Institute for her work in cancer immunotherapy and cell stress, one of which is part of the Cancer Moonshot Initiative on immunometabolism.

23 Jul 2020

Preclinical News and Research

Regeneron antibody cocktail shows promise as potential COVID-19 treatment

Five alternative methods of SARS-CoV-2 suppression

Immune system's oldest branches may underpin COVID severity

The race to a coronavirus vaccine

Touchlight, Cancer Research UK and University of Southampton team up to develop DNA cancer vaccine

Investigational drug shows promising results for treating HNSCC tumors

Study reports highly potent anti-SARS-CoV-2 compounds

Researchers launch randomized, placebo-controlled clinical trial of pulmozyme in COVID-19 patients

Simple blood test may be a great advance for people with and at risk for Alzheimer's

A new cell-based gene therapy approach to better treat patients with hemophilia A

Discovery could pave way for a blood test to diagnose Alzheimer's before symptoms appear

Novel drug candidate offers a major advance in the treatment for diabetes

Two-step targeting strategy can increase clinical translation of nanoparticle-based therapies

Curi Bio Acquires Dana Solutions

Study finds a sharp decline in heart transplants during the pandemic

Experimental mRNA-based COVID-19 vaccine elicits protective immune responses in animals

Researchers discover new method to treat herpes viruses

Boehringer Ingelheim and Biognosys join forces on applying quantitative proteomics tools in drug discovery

Study shows inert drug ingredients could lead to unanticipated side effects

Hollings Cancer Center researcher receives NCI grants for cancer immunotherapy studies

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