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Developing the Next Generation of Water-soluble DREADDs

An interview with James Flanaghan, discussing the uses of DREADDs in neurobiological research and the advantages of water-soluble ligands.

From Hello Bio 19 Dec 2018

New drug could significantly slow progression of ALS, shows research

A new drug could significantly slow the progression of ALS, also known as Lou Gehrig's disease, according to new research by University of Alberta biologists. Current treatments slow progression of the degenerative disease by only a few months, and these findings could revolutionize the treatment of patients suffering from ALS, extending and improving quality of life.

18 Dec 2018

Researchers discover promising new compound against Buruli ulcer

Buruli ulcer - one of the most neglected among the NTDs - is a debilitating and stigmatizing disease. Affecting mainly children in West and Central Africa, the chronic disease results in devastating skin lesions and can lead to permanent disfigurement and long-term disabilities.

18 Dec 2018

CTF along with NTAP and Sage announce first-ever open data portal for neurofibromatosis

The Children's Tumor Foundation, together with the Neurofibromatosis Therapeutic Acceleration Program and Sage Bionetworks, has announced the first-ever open data portal for scientific research results in the field of neurofibromatosis.

17 Dec 2018

Recent developments and challenges in hMAT inhibitors

Zhu et al. have reviewed the recent developments in the knowledge about the binding, inhibitory mechanisms and structure-activity relationships of hSERT, hNET and hDAT, which are primary human monoamine transporters hMATs.

14 Dec 2018

Study shows septin proteins detect and kill gut pathogen, Shigella

Using state-of-the art technologies to image human cells and study infection at the level of a single bacterial cell, the research team, led by the London School of Hygiene & Tropical Medicine, has uncovered the strongest evidence yet that septins take Shigella prisoner.

13 Dec 2018

Scientists develop new stem cell line to study conversion of stem cells into muscle

To help patients with muscle disorders, scientists at The University of Texas Health Science Center at Houston (UTHealth) have engineered a new stem cell line to study the conversion of stem cells into muscle. Findings appeared in Cell Reports.

13 Dec 2018

NanoBioCel group develops lipid vesicles that can genetic material efficiently and viably

In a piece of research conducted in collaboration, the NanoBioCel group of the UPV/EHU's Faculty of Pharmacy, and the University of Elche have designed some niosomes, which are lipid vesicles for use in gene therapies designed to treat diseases of the central nervous system.

4 Dec 2018

Scientist.com and Allele Biotechnology partner to develop therapeutic nanoantibodies

Scientist.com, the world's leading marketplace for outsourced scientific services, and Allele Biotechnology & Pharmaceuticals Inc., a leading San Diego-based preclinical-stage biopharmaceutical company, have partnered to develop nanoantibodies for therapeutic applications.

3 Dec 2018

New strategy for developing cell replacement therapies to combat type 1 diabetes

Scientists have discovered the signals that determine the fate of immature cells in the pancreas. The research shows that they are very mobile and that their destiny is strongly influenced by their immediate environment.

29 Nov 2018

Super bugs “supercharging” on the International Space Station

Researchers and microbiologists at the Jet Propulsion Laboratory NASA, had found that there were five different types of Enterobacter present in the toilets and exercise areas on the ISS.

29 Nov 2018

New nanoscale technique developed to get more information from the blood of cancer patients

A technique to get more information from the blood of cancer patients than previously possible has been developed.

28 Nov 2018

Scientists visualize action of immune cells in response to cancer cell proliferation

As tumors develop, they evolve genetically. How does the immune system act when faced with tumor cells? How does it exert pressure on the genetic diversity of cancer cells? Scientists from the Institut Pasteur and Inserm used in vivo video techniques and cell-specific staining to visualize the action of immune cells in response to the proliferation of cancer cells.

28 Nov 2018

Pitt research team explores whether 'active wrinkles' may help improve synthetic graft design

During a coronary bypass procedure, surgeons redirect blood flow using an autologous bypass graft, most often derived from the patient's own veins. However, in certain situations where the patient does not have a suitable vein, surgeons must rely on synthetic vascular grafts which, while life-saving, are more prone to clot formation that eventually obstructs the graft.

28 Nov 2018

Using Pre-Clinical Imaging to Detect Cancer

In this interview, Émilie Beaulieu Ouellet, Application Scientist for life science imaging at Photon Etc talks to New-Medical about their range of preclinical infrared imagers and how they can allow cancer detection.

From Photon etc. 27 Nov 2018

Study reveals mechanism by which malaria parasite converts from its asexual to sexual form

A study led by the Barcelona Institute for Global Health (ISGlobal) - an institution supported by "la Caixa" Foundation- reveals a new mechanism by which the malaria parasite Plasmodium falciparum converts from its asexual to its sexual form, which can be transmitted to the mosquito.

27 Nov 2018

Gene-brain association occurs differently in toddlers with autism and poor language development

An international team of scientists, led by researchers at the University of Cyprus and University of California San Diego School of Medicine, have identified a previously unknown, large-scale association between molecular gene expression activity in blood leukocyte cells and altered neural responses to speech in toddlers with autism as measured with functional magnetic resonance imaging (fMRI).

27 Nov 2018

Scientists develop new surgical process for studying the thymus

Elisa Oltra, head of the Genetic Exppression and Immunity group of the Faculty of Medicine at the Catholic University of Valencia, in collaboration with Alejandro Caicedo, professor of the Department of Medicine of the University of Miami, have developed a surgical process which makes it possible to place functional fragments of the thymus in the anterior chamber of the eyes of mice.

26 Nov 2018

Novel DNA nanoplatform delivers anticancer agents to multidrug-resistant tumors

One of the most successful techniques to combat multidrug resistance in cancer cells is the downregulation of those genes responsible for drug resistance.

22 Nov 2018

Researchers elucidate infection process of bacterial pathogen Clostridium difficile

Scientists from the VIB-UGent Center for Inflammation Research identified the mechanisms by which the bacterial pathogen Clostridium difficile kills intestinal epithelial cells, thus destroying the protective mucosal barrier of the intestinal tract.

21 Nov 2018

in vivo News and Research

Developing the Next Generation of Water-soluble DREADDs

New drug could significantly slow progression of ALS, shows research

Researchers discover promising new compound against Buruli ulcer

CTF along with NTAP and Sage announce first-ever open data portal for neurofibromatosis

Recent developments and challenges in hMAT inhibitors

Study shows septin proteins detect and kill gut pathogen, Shigella

Scientists develop new stem cell line to study conversion of stem cells into muscle

NanoBioCel group develops lipid vesicles that can genetic material efficiently and viably

Scientist.com and Allele Biotechnology partner to develop therapeutic nanoantibodies

New strategy for developing cell replacement therapies to combat type 1 diabetes

Super bugs “supercharging” on the International Space Station

New nanoscale technique developed to get more information from the blood of cancer patients

Scientists visualize action of immune cells in response to cancer cell proliferation

Pitt research team explores whether 'active wrinkles' may help improve synthetic graft design

Using Pre-Clinical Imaging to Detect Cancer

Study reveals mechanism by which malaria parasite converts from its asexual to sexual form

Gene-brain association occurs differently in toddlers with autism and poor language development

Scientists develop new surgical process for studying the thymus

Novel DNA nanoplatform delivers anticancer agents to multidrug-resistant tumors

Researchers elucidate infection process of bacterial pathogen Clostridium difficile

eBook: Using iPSCs models for human disease research and drug discovery eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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