Cell Death News and Research

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Researchers identify key step to prevent liver failure resulting from painkiller overdose

University of Adelaide researchers have identified a key step for the future prevention of liver failure resulting from taking too much of the everyday painkiller paracetamol (also known as acetaminophen).

5 Feb 2014

Protein study opens new avenue for cancer researchers

One of the hopes for victory against cancer hinges on naturally-occurring proteins whose job is to make their host cell die. Since their natural role is to stop unhealthy cell proliferation, the idea is that one or more of these proteins could be harnessed to stop the growth of tumors.

3 Feb 2014

Drugs that modify DNA structure may be beneficial for treating Alzheimer's disease

In a study published this week in Nature Neuroscience, Bess Frost, PhD, and co-authors, identify abnormal expression of genes, resulting from DNA relaxation, that can be detected in the brain and blood of Alzheimer's patients.

31 Jan 2014

Study points to gender-specific mechanisms of brain repair following oxygen deprivation

Physicians have long known that oxygen deprivation to the brain around the time of birth causes worse damage in boys than girls. Now a study by researchers from the Johns Hopkins Children’s Center conducted in mice reveals one possible reason behind this gender disparity and points to gender-specific mechanisms of brain repair following such injury.

31 Jan 2014

New molecule could help lower diabetic patients' risk of developing dementia or Alzheimer's

Researchers at the Hebrew university of Jerusalem have created a molecule that could potentially lower diabetic patients' higher risk of developing dementia or Alzheimer's disease.

30 Jan 2014

New molecule reduces diabetic patients' higher risk of developing dementia, Alzheimer's

Researchers at the Hebrew university of Jerusalem have created a molecule that could potentially lower diabetic patients' higher risk of developing dementia or Alzheimer's disease.

28 Jan 2014

Large-scale analysis of over 20 tumor types increases catalog of cancer genes by 25%

A landmark study across many cancer types reveals that the universe of cancer mutations is much bigger than previously thought. By analyzing the genomes of thousands of patients' tumors, a Broad Institute-led research team has discovered many new cancer genes - expanding the list of known genes tied to these cancers by 25 percent. Moreover, the study shows that many key cancer genes still remain to be discovered.

25 Jan 2014

First patient enrolled pilot clinical trial of NovoTTF Therapy plus gemcitabine for pancreatic adenocarcinoma

Novocure announced today that the first patient has enrolled in the EF-20 Study, an open label, pilot clinical trial of NovoTTF Therapy plus gemcitabine as first-line therapy for patients with locally advanced and metastatic pancreatic adenocarcinoma.

25 Jan 2014

New drugs for treatment of prostate cancer may not target root cause of the disease

NEW drugs being developed for the treatment of prostate cancer may not be targeting the root cause of the disease, according to research published today (Friday, 24 January 2014) in Cell Death & Differentiation.

25 Jan 2014

Scientists identify genetic alterations in pediatric soft-tissue cancer

Scientists have mapped the genetic changes that drive tumors in rhabdomyosarcoma, a pediatric soft-tissue cancer, and found that the disease is characterized by two distinct genotypes. The genetic alterations identified in this malignancy could be useful in developing targeted diagnostic tools and treatments for children with the disease. The study, by researchers at the National Cancer Institute, part of the National Institutes of Health, and their colleagues, appeared in the Jan. 23, 2014, issue of the journal Cancer Discovery.

24 Jan 2014

New techniques simplify current test procedures for developing new medications

When developing new medications, biologists and pharma- cologists test different active ingredients and chemical compounds. The main purpose is to find out how biological cells react to these substances.

24 Jan 2014

Scientists map genetic changes that drive tumors pediatric soft-tissue cancer

Scientists have mapped the genetic changes that drive tumors in rhabdomyosarcoma, a pediatric soft-tissue cancer, and found that the disease is characterized by two distinct genotypes.

24 Jan 2014

TSRI study shows how aging affects brain's neural circuitry

How aging affects communication between neurons is not well understood, a gap that makes it more difficult to treat a range of disorders, including Alzheimer's and Parkinson's disease.

23 Jan 2014

UT Southwestern' faculty receives Stanley J. Korsmeyer Award for contributions to understanding of autophagy

Dr. Beth Levine, a Howard Hughes Medical Institute Investigator and Director of the Center for Autophagy Research at UT Southwestern Medical Center, has received the 2014 Stanley J. Korsmeyer Award from the American Society for Clinical Investigation.

22 Jan 2014

TSRI scientists use new technique to discover two antibodies that protect human cells from cold virus

Scientists at The Scripps Research Institute (TSRI) have demonstrated the power of a new drug discovery technique, which allows them to find-relatively quickly and cheaply-antibodies that have a desired effect on cells. The TSRI scientists used the technique to discover two antibodies that protect human cells from a cold virus.

20 Jan 2014

Studies aim to address urgent need to identify possible new methods for mesothelioma treatment

Mesothelioma is a very aggressive cancer associated with asbestos exposure, which is usually diagnosed in an advanced stage. So far no therapeutic strategy has proven effective against this deadly cancer and the prognosis remains very poor with only few exceptions.

20 Jan 2014

Research findings may offer new therapeutic target for management of Gaucher diseas

What causes brain damage and inflammation in severe cases of Gaucher disease? Little is known about the events that lead to brain pathology in some forms of the disease, and there is currently no treatment available - a bleak outlook for sufferers and their families. Now, scientists at the Weizmann Institute of Science have discovered a new cellular pathway implicated in Gaucher disease.

19 Jan 2014

BioTime subsidiary releases version 1.5 of LifeMap Discovery

LifeMap Sciences, Inc., a subsidiary of BioTime, Inc., announced today the release of LifeMap Discovery version 1.5. LifeMap Discovery is a state-of-the-art roadmap of embryonic development and stem cell biology.

18 Jan 2014

Gene therapies correct three forms of retinal degenerative diseases

Gene therapies developed by University of Pennsylvania School of Veterinary Medicine researchers have worked to correct different forms of blindness. While effective, the downside to these approaches to vision rescue is that each disease requires its own form of gene therapy to correct the particular genetic mutation involved, a time consuming and complex process.

17 Jan 2014

Research uncovers new mechanism in brain cells that may help keep deadly neurological diseases in check

New research from David Westaway, PhD, of the University of Alberta and Jiri Safar, MD, Case Western Reserve University School of Medicine has uncovered a quality control mechanism in brain cells that may help keep deadly neurological diseases in check for months or years.

17 Jan 2014

Cell Death News and Research

Researchers identify key step to prevent liver failure resulting from painkiller overdose

Protein study opens new avenue for cancer researchers

Drugs that modify DNA structure may be beneficial for treating Alzheimer's disease

Study points to gender-specific mechanisms of brain repair following oxygen deprivation

New molecule could help lower diabetic patients' risk of developing dementia or Alzheimer's

New molecule reduces diabetic patients' higher risk of developing dementia, Alzheimer's

Large-scale analysis of over 20 tumor types increases catalog of cancer genes by 25%

First patient enrolled pilot clinical trial of NovoTTF Therapy plus gemcitabine for pancreatic adenocarcinoma

New drugs for treatment of prostate cancer may not target root cause of the disease

Scientists identify genetic alterations in pediatric soft-tissue cancer

New techniques simplify current test procedures for developing new medications

Scientists map genetic changes that drive tumors pediatric soft-tissue cancer

TSRI study shows how aging affects brain's neural circuitry

UT Southwestern' faculty receives Stanley J. Korsmeyer Award for contributions to understanding of autophagy

TSRI scientists use new technique to discover two antibodies that protect human cells from cold virus

Studies aim to address urgent need to identify possible new methods for mesothelioma treatment

Research findings may offer new therapeutic target for management of Gaucher diseas

BioTime subsidiary releases version 1.5 of LifeMap Discovery

Gene therapies correct three forms of retinal degenerative diseases

Research uncovers new mechanism in brain cells that may help keep deadly neurological diseases in check

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