Genes News and Research

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DNA repair mutations act as a switch for bowel cancer

Bowel cancer cells have the ability to regulate their growth using a genetic on-off switch to maximize their chances of survival, a phenomenon that's been observed for the first time by researchers at UCL and University Medical Center Utrecht.

5 Jul 2024

Heparan-sulfate proteoglycans found to influence Alzheimer's cell pathology

The impact of heparan-sulfate-modified proteoglycans (HSPGs) on Alzheimer's disease-associated pathways.

5 Jul 2024

Researchers discover rare types of helper T cells associated with immune disorders

Researchers led by Yasuhiro Murakawa at the RIKEN Center for Integrative Medical Sciences (IMS) and Kyoto University in Japan and IFOM ETS in Italy have discovered several rare types of helper T cells that are associated with immune disorders such as multiple sclerosis, rheumatoid arthritis, and even asthma.

4 Jul 2024

Turning cancer cells against themselves to overcome drug resistance

Treating cancer can sometimes feel like a game of Whac-A-Mole. The disease can become resistant to treatment, and clinicians never know when, where and what resistance might emerge, leaving them one step behind.

4 Jul 2024

More than 1,000 small changes in DNA identified that influence age of first period

Researchers examined nearly 800,000 women's DNA to explore puberty timing complexities. They identified signals related to menarche timing and investigated their influence on puberty onset.

4 Jul 2024

Scientists unveil KLF15 transcription factor's role in white fat cells, opening new paths for obesity therapy

Researchers found that KLF15 is crucial for maintaining white adipocyte properties in subcutaneous fat, and its deletion induces beige adipocyte characteristics, suggesting new obesity treatment pathways.

4 Jul 2024

Healthy lifestyle can overcome genetic risk of obesity, new study reveals

Study demonstrates that adherence to a healthy lifestyle can significantly mitigate the genetic risk of obesity and its related morbidities, emphasizing the importance of promoting healthy behaviors irrespective of genetic predisposition.

4 Jul 2024

Research reveals how motorized processes shape chromosome structure development

Researchers at Rice University are making strides in understanding how chromosome structures change throughout the cell's life cycle.

3 Jul 2024

Study offers new insights into the evolution of foldable proteins

A new study led by Rice University's Peter Wolynes offers new insights into the evolution of foldable proteins. The research was published in the Proceedings of the National Academy of Sciences.

3 Jul 2024

White blood cell type identified as important contributor to inflammation in obesity

Researchers explored neutrophil involvement in visceral adipose tissue (VAT) inflammation in obesity.

3 Jul 2024

Key differences in RNA editing found between postmortem and living brain

Researchers examined the adenosine-to-inosine (A-to-I) nucleoside editing of postmortem and live prefrontal cortical tissues.

3 Jul 2024

Gene discovery points to oxytocin for depression

While investigating two boys from different families with severe obesity, anxiety, autism, and behavioural problems triggered by sounds or smells, a team led by scientists at the University of Cambridge, UK, and Baylor College of Medicine, Houston, USA, discovered that the boys were missing a single gene, known as TRPC5, which sits on the X chromosome.

3 Jul 2024

RNA splicing modulation as a precision approach for neuroendocrine cancer treatment

Neuroendocrine tumors, including small cell lung cancer and neuroendocrine prostate cancer, are very aggressive with high chances of spreading.

2 Jul 2024

AI uncovers potential cancer drivers hidden in 'junk' regions of DNA

Using artificial intelligence, Garvan Institute researchers have found potential cancer drivers hidden in so-called 'junk' regions of DNA, opening up possibilities for a new approach to diagnosis and treatment.

2 Jul 2024

Novel mathematical approach reveals shared gene programs in anti-tumor CD8+ T cells

We set out to identify genes that are commonly expressed in CD8+ T cells, killer immune cells that can drive anti-tumor immunity, across many types of human cancers.

2 Jul 2024

Ribosomes and ZAK protein spur the cell's initial response to UV radiation damage

In a recent study, researchers at Johns Hopkins Medicine suggest the cell's messenger RNA (mRNA) - the major translator and regulator of genetic material - along with a critical protein called ZAK, spur the cell's initial response to UV radiation damage and play a critical role in whether the cell lives or dies.

2 Jul 2024

Innovative HIV vaccine approaches yield potential for broad protection against viral strains

A major challenge in developing a vaccine for HIV is that the virus mutates fast - very fast. Although a person initially becomes infected with one or a few HIV strains, the virus replicates and mutates quickly, resulting in a "swarm" of viral strains existing in a single body.

2 Jul 2024

Frequent infections and pathobionts boost children's nasal immunity, study reveals

Dynamic interactions with viruses and bacterial pathobionts significantly enhance nasal innate immunity in children, revealing distinct immunophenotypes driven by microbial load and type.

2 Jul 2024

Study finds promising new target for the treatment of Alzheimer's disease

A class of proteins that regulates cell repair and enhances cell growth-signaling systems could be a promising new target for the treatment of Alzheimer's and other neurodegenerative diseases, according to a new study led by researchers at Penn State.

2 Jul 2024

Key transcription factor enhances anthocyanin production in wounded grapevines

A recent study sheds light on the biochemical response of grapevines to wounding stress. It reveals that the transcription factor VvWRKY5 is a key regulator that enhances anthocyanin production, which serves as a protective mechanism for the plant.

2 Jul 2024

Genes News and Research

DNA repair mutations act as a switch for bowel cancer

Heparan-sulfate proteoglycans found to influence Alzheimer's cell pathology

Researchers discover rare types of helper T cells associated with immune disorders

Turning cancer cells against themselves to overcome drug resistance

More than 1,000 small changes in DNA identified that influence age of first period

Scientists unveil KLF15 transcription factor's role in white fat cells, opening new paths for obesity therapy

Healthy lifestyle can overcome genetic risk of obesity, new study reveals

Research reveals how motorized processes shape chromosome structure development

Study offers new insights into the evolution of foldable proteins

White blood cell type identified as important contributor to inflammation in obesity

Key differences in RNA editing found between postmortem and living brain

Gene discovery points to oxytocin for depression

RNA splicing modulation as a precision approach for neuroendocrine cancer treatment

AI uncovers potential cancer drivers hidden in 'junk' regions of DNA

Novel mathematical approach reveals shared gene programs in anti-tumor CD8+ T cells

Ribosomes and ZAK protein spur the cell's initial response to UV radiation damage

Innovative HIV vaccine approaches yield potential for broad protection against viral strains

Frequent infections and pathobionts boost children's nasal immunity, study reveals

Study finds promising new target for the treatment of Alzheimer's disease

Key transcription factor enhances anthocyanin production in wounded grapevines

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