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Researchers uncover a key role for SIRT1 enzyme in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive type of leukemia. Despite advances in treatments, patients have an extremely poor prognosis, highlighting the need to explore the genetic components that lead to the formation of T-ALL, as well as the need to discover new targeted therapeutic approaches and treatment resistance.

14 Dec 2021

Scientists describe dynamic genomic landscape of tumor heterogeneity in hepatocellular carcinoma

Clinician scientists and scientists from the National Cancer Centre Singapore and A*STAR's Genome Institute of Singapore, in collaboration with Singapore General Hospital, the National University Health System, Duke-NUS Medical School, Nanyang Technological University, and collaborators from China, Malaysia, Thailand and the Philippines, have described a dynamic genomic landscape of tumour heterogeneity in hepatocellular carcinoma (HCC).

13 Dec 2021

Novel therapy found to be safe and well-tolerated in patients with bone marrow cancer

Mount Sinai physician-scientists have found that a novel therapy for the bone marrow cancer myelofibrosis is safe and well-tolerated and is associated with modest improvements in patients in a Phase 1b clinical trial.

12 Dec 2021

Potentially serious side effect reported after CAR-T cell therapy for multiple myeloma

Mount Sinai scientists have become the first to report a potentially serious side effect related to a new form of immunotherapy known as CAR-T cell therapy, which was recently approved for the treatment of multiple myeloma.

11 Dec 2021

Development of school-based wellness initiative for tackling childhood obesity

Medical University of South Carolina researchers describe the development of a school-based wellness initiative for combating childhood obesity by the MUSC Boeing Center for Children's Wellness in the November issue of the Journal of School Health.

11 Dec 2021

New insights about COVID-19 vaccination rates among people living with HIV

The AIDS Clinical Trials Group, the largest global HIV research network, which recently expanded its focus to include evaluating outpatient treatment for COVID-19, today announced that insights around COVID-19 vaccination rates among people living with HV have been published in the Journal of Infectious Diseases.

10 Dec 2021

Prescribing generic heart medications in Medicare Part D could result in substantial savings

Prescribing generic medications for heart and blood vessel diseases more frequently instead of brand-name medications in Medicare's prescription drug program, called Part D, could save more than $600 million each year in the U.S., according to new research published today in Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal.

9 Dec 2021

UEA researchers reveal how immune cells use the body’s fat stores to fight infection

New research from the University of East Anglia and Quadram Institute reveals how our immune cells use the body’s fat stores to fight infection.

9 Dec 2021

Research provides new insights into debilitating cluster headaches

Debilitating cluster headaches commonly begin in childhood, but patients are not typically diagnosed until they are adults, according to research from The University of Texas Health Science Center at Houston.

8 Dec 2021

Optimizing the treatment of epilepsy patients

Researchers have devised a new diagnostic model to predict how generalized epilepsy patients will respond to drug treatment.

8 Dec 2021

Study analyzes the contribution of AI to cancer patient care and vaccine design

Artificial Intelligence/Machine Learning (AI/ML) is the development of computer systems that are able to perform tasks that would normally require human intelligence. AI/ML is used by people every day, for example, while using smart home devices or digital voice assistants.

8 Dec 2021

Consuming a diet of pro-inflammatory foods linked to frailty risk in middle-aged and older adults

Results of a study published in the American Journal of Clinical Nutrition indicate that regularly consuming a diet of pro-inflammatory foods (e.g., those rich in simple carbohydrates or in saturated fats) is associated with increased likelihood of developing frailty in middle-aged and older adults.

8 Dec 2021

Antibody response to COVID-19 vaccine may be affected by the body’s circadian rhythms

Our internal 24-hour circadian clock regulates many aspects of physiology, including the response to infectious disease and vaccination.

7 Dec 2021

Hypercoagulability of the blood responsible for cardiac thrombosis in COVID-19 patients

Researchers examined autopsy tissue samples of hearts from patients who died early in the COVID-19 pandemic.

7 Dec 2021

People who exercise regularly have lower risk of developing and dying from pneumonia

People who exercise regularly can reduce their risk of developing and dying from pneumonia, new research has found.

7 Dec 2021

Survey reveals bullying of one in 10 cardiology trainee doctors in the UK

One in 10 junior doctors training to be cardiologists in the UK, say they have been bullied, reveal the results of a survey published online in the journal Heart.

7 Dec 2021

Study finds mRNA-based COVID-19 vaccines are effective in cancer patients

The mRNA-based COVID-19 vaccines are effective at preventing infection in most cancer patients, according to a nationwide study of veterans diagnosed with cancer in the past decade.

6 Dec 2021

Study reveals the effects of cannabis use on oral microbiome and brain health

More and more states are legalizing marijuana, but little is known about how long-term cannabis use affects the microbes in the oral cavity, known as the oral microbiome.

6 Dec 2021

New analysis finds increase in the rate of underinsured youngsters

In a concerning trend for the health of U.S. children, the rate of underinsured youngsters rose from 30.6% to 34%- an additional 2.4 million kids- from 2016 to 2019, according to an analysis led by University of Pittsburgh School of Medicine researchers.

6 Dec 2021

Researchers use gene-editing to create single sex mice litters

Scientists at the Francis Crick Institute, in collaboration with University of Kent, have used gene editing technology to create female-only and male-only mice litters with 100% efficiency.

6 Dec 2021

Medical School News and Research

Researchers uncover a key role for SIRT1 enzyme in T-cell acute lymphoblastic leukemia

Scientists describe dynamic genomic landscape of tumor heterogeneity in hepatocellular carcinoma

Novel therapy found to be safe and well-tolerated in patients with bone marrow cancer

Potentially serious side effect reported after CAR-T cell therapy for multiple myeloma

Development of school-based wellness initiative for tackling childhood obesity

New insights about COVID-19 vaccination rates among people living with HIV

Prescribing generic heart medications in Medicare Part D could result in substantial savings

UEA researchers reveal how immune cells use the body’s fat stores to fight infection

Research provides new insights into debilitating cluster headaches

Optimizing the treatment of epilepsy patients

Study analyzes the contribution of AI to cancer patient care and vaccine design

Consuming a diet of pro-inflammatory foods linked to frailty risk in middle-aged and older adults

Antibody response to COVID-19 vaccine may be affected by the body’s circadian rhythms

Hypercoagulability of the blood responsible for cardiac thrombosis in COVID-19 patients

People who exercise regularly have lower risk of developing and dying from pneumonia

Survey reveals bullying of one in 10 cardiology trainee doctors in the UK

Study finds mRNA-based COVID-19 vaccines are effective in cancer patients

Study reveals the effects of cannabis use on oral microbiome and brain health

New analysis finds increase in the rate of underinsured youngsters

Researchers use gene-editing to create single sex mice litters

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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