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Scientists identify a cryptic SARS-CoV-2 lineage in wastewater

In a recent study posted to the medRxiv* preprint server, researchers in the United States investigated the source of an enigmatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern (VOC)-like spike (S) protein strain detected in wastewater but not in clinical samples.

2 Nov 2022

Nebulized mRNA-encoded antibodies found to protect hamsters against COVID-19

New research describes a novel route of prevention, using messenger ribonucleic acid (mRNA) molecules that encode protective antibodies within the recipient.

2 Nov 2022

Memory: a revolutionary treatment for mental health disorders and neurodegeneration?

In this interview, we speak to Dr. Steve Ramirez about his latest neuroscience research that investigated the power of our memories.

2 Nov 2022

Effectiveness of prior infection in preventing reinfection with SARS-CoV-2 Omicron BA.2.75 sublineage

Researchers used a test-negative, case-control study design to estimate the effectiveness of prior infection in preventing reinfection with Omicron BA.2.75.2 subvariant in the Qatar population.

2 Nov 2022

Study finds possible treatment strategy for Feingold syndrome type 1

A decrease in protein synthesis in cells of the developing gut contributes to a rare genetic disorder, and an inexpensive nutritional supplement may help reverse that decrease, according to a new study publishing November 1st in the open access journal PLOS Biology by Yun-Fei Li of Zhejiang University School of Medicine in Hangzhou, China, and colleagues. The finding is an advance in understanding the pathogenesis of the disease, and may lead to new treatments.

2 Nov 2022

Study highlights the importance of poverty in criminal conviction

A significant reduction in childhood poverty could cut criminal convictions by almost a quarter, according to a study conducted in Brazil. An article on the study is published in Scientific Reports. The researchers used an innovative approach involving an analysis of 22 risk factors that affect human development and interviews with 1,905 children at two points – a first interview to form a baseline (mean age 10.3) and a follow-up interview seven years later (mean age 17.8).

2 Nov 2022

Progress and challenges in the development of mRNA vaccines against respiratory syncytial virus

New research discussed the structure and life cycle of respiratory syncytial virus (RSV), the current research on the treatment and prevention of RSV infections, and the advancements in RSV mRNA vaccine technology after the surge in vaccine research during the COVID-19 pandemic.

1 Nov 2022

Researchers unravel how the brain chemical dopamine relates to schizophrenia

Researchers at the Lieber Institute for Brain Development (LIBD) believe they have solved a riddle that has challenged scientists for more than 70 years: how the brain chemical dopamine relates to schizophrenia, the often-devastating brain disorder characterized by delusional thinking, hallucinations and other forms of psychosis.

1 Nov 2022

Exploring viral loads of SARS-CoV-2 Omicron BA.5 and BA.2 sublineages

In a new study, researchers compared the viral loads of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.5 and BA.2 sublineages.

1 Nov 2022

Researchers find the root of immunosuppression and chemoresistance in TNBC tumors

Triple-negative breast cancer (TNBC) tumors gain immunosuppression and chemoresistance through interactions between interleukin 34 and myeloid-derived suppressor cells, researchers find.

1 Nov 2022

What is the impact of SARS-CoV-2 on HIV-1 infectivity?

In a new study, researchers assessed the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV envelope (E) proteins on human immunodeficiency virus type 1 (HIV-1) infectivity.

31 Oct 2022

Large listeriosis outbreak in Spain caused by contaminated stuffed pork

Listeria bacteria are ubiquitous in the environment and consumption of food contaminated with Listeria monocytogenes is one of the main routes for food-borne outbreaks.

28 Oct 2022

Research reveals a differential clinical response to pembrolizumab in uterine cancer patients

New research from Yale Cancer Center reveals for the first time ever a differential clinical response to pembrolizumab in Lynch-like (mutated) vs methylated microsatellite instability-high (MSI-H) uterine cancer patients, increasing our understanding about the proportion of patients that derive benefit from immune checkpoint blockade.

28 Oct 2022

New breakthrough in understanding how deletion of certain genes can lead to cancer growth

Genetic mutations kick start cancers. Some mutations shuffle the genetic code, others come from the deletion of key genes.

28 Oct 2022

Proof-of-principle study: Novel tool advances potential way to deliver gene therapy

Johns Hopkins Medicine researchers say they have successfully used a cell's natural process for making proteins to "slide" genetic instructions into a cell and produce critical proteins missing from those cells.

28 Oct 2022

Ancient viral DNA in human genomes protects cells against present-day viruses

Viral DNA in human genomes, embedded there from ancient infections, serve as antivirals that protect human cells against certain present-day viruses, according to new research.

27 Oct 2022

Researchers use CRISPR-edited T cells to treat seriously ill children with resistant leukaemia

Researchers at Great Ormond Street Hospital for Children (GOSH) and UCL Great Ormond Street Institute of Child Health (UCL GOS ICH) have used CRISPR/Cas9 technology to engineer donor T cells to try to treat seriously ill children with resistant leukaemia, who had otherwise exhausted all available therapies.

27 Oct 2022

Genome News and Research

Scientists identify a cryptic SARS-CoV-2 lineage in wastewater

Nebulized mRNA-encoded antibodies found to protect hamsters against COVID-19

Memory: a revolutionary treatment for mental health disorders and neurodegeneration?

Effectiveness of prior infection in preventing reinfection with SARS-CoV-2 Omicron BA.2.75 sublineage

Study finds possible treatment strategy for Feingold syndrome type 1

Study highlights the importance of poverty in criminal conviction

Progress and challenges in the development of mRNA vaccines against respiratory syncytial virus

Researchers unravel how the brain chemical dopamine relates to schizophrenia

Exploring viral loads of SARS-CoV-2 Omicron BA.5 and BA.2 sublineages

Researchers find the root of immunosuppression and chemoresistance in TNBC tumors

What is the impact of SARS-CoV-2 on HIV-1 infectivity?

Large listeriosis outbreak in Spain caused by contaminated stuffed pork

Research reveals a differential clinical response to pembrolizumab in uterine cancer patients

New breakthrough in understanding how deletion of certain genes can lead to cancer growth

Proof-of-principle study: Novel tool advances potential way to deliver gene therapy

Ancient viral DNA in human genomes protects cells against present-day viruses

Researchers use CRISPR-edited T cells to treat seriously ill children with resistant leukaemia

RNA-sensing platform could help detect and selectively kill tumors, or edit the genome in specific cells

Using stem cell cloning to identify the origin of lethal stomach and esophageal cancers

Researchers find a switch to regulate the diabetes-causing gene

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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