Proliferation News and Research

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Curcumin, cancer-inhibiting peptides show promise in slowing progression of mesothelioma

A common Asian spice and cancer-hampering molecules show promise in slowing the progression of mesothelioma, a cancer of the lung's lining often linked to asbestos. Scientists from Case Western Reserve University and the Georg-Speyer-Haus in Frankfurt, Germany, demonstrate that application of curcumin, a derivative of the spice turmeric, and cancer-inhibiting peptides increase levels of a protein inhibitor known to combat the progression of this cancer.

22 Sep 2014

Longer telomeres increase melanoma risk

A leading Dartmouth researcher, working with The Melanoma Genetics Consortium, GenoMEL, an international research consortium, co-authored a paper published today in the Journal of the National Cancer Institute that proves longer telomeres increase the risk of melanoma.

21 Sep 2014

Rosuvastatin promotes bone growth in mice with achondroplasia symptoms

Skeletal dysplasia is a group of rare diseases that afflict skeletal growth through abnormalities in bone and cartilage. Its onset hits at the fetal stage and is caused by genetic mutations.

18 Sep 2014

Disrupting cancer regulator MYC: an interview with Professor Kim Janda

MYC is an oncogenic member of the basic helix-loop-helix-leucine zipper transcription factor family. In its monomeric form, MYC’s tertiary structure is intrinsically disordered and the protein is transcriptionally inactive.

17 Sep 2014

Ramucirumab effective second-line option for NSCLC

The monoclonal antibody ramucirumab, when added to second-line docetaxel, significantly improves the overall survival of patients with stage IV non-small-cell lung cancer, show the findings of the REVEL trial.

17 Sep 2014

Specific blood test could indicate neoadjuvant treatment regimens for ESCC patients

A blood test may be beneficial in indicating neoadjuvant treatment regimens for patients with esophageal squamous cell carcinoma (ESCC), according to research presented today at the American Society for Radiation Oncology's 56th Annual Meeting.

16 Sep 2014

Blocking bacteria's access to iron: an interview with Dr. Laxminarayana Devireddy

Iron is a key nutrient for nearly all living organisms, including bacteria. Iron is a cofactor for many enzymes necessary for basic metabolic reactions such as DNA synthesis and electron transport. Iron serves as the conduit for the electron transport chain that generates the energy necessary to drive the bacterial cell.

16 Sep 2014

Collaborative study takes important step toward finding targeted treatments for bladder cancer

The story of cancer care seems so simple: find the mutated gene that causes cancer and turn it off or fix it. But rarely does a single gene cause cancer. More often, many genes are altered together to drive the disease. So the challenge becomes sorting out which altered genes are the most to blame in which cancers.

16 Sep 2014

Researchers find learning and memory components of neurofibromatosis using zebrafish model

Using a zebrafish model of a human genetic disease called neurofibromatosis (NF1), a team from the Perelman School of Medicine at the University of Pennsylvania has found that the learning and memory components of the disorder are distinct features that will likely need different treatment approaches.

15 Sep 2014

Scientists crack genetic code of liver fluke parasite

Singapore-An international team of scientists from Singapore, Thailand, China and Australia has cracked the genetic code of the liver fluke parasite, Opisthorchis viverrini, using a unique DNA analysis technique developed at A*STAR's Genome Institute of Singapore (GIS).

11 Sep 2014

Viewpoints: Medicaid and assets; a surprising look at narrow networks

The 2010 federal health care reform law required virtually all adult Americans to carry insurance, starting this year. And to help make policies affordable, it offered subsidies to lower-income households while expanding the Medicaid insurance program to more of the poorest residents.

11 Sep 2014

Growth factors present in human breast milk may protect against intestinal damage

Studies Suggest that ErbB4 Receptor Activation May Be a Novel Therapeutic Avenue for Intestinal Diseases Involving Epithelial Cell Death, According to Research Published in The American Journal of Pathology

10 Sep 2014

Researchers pave way for development of new generation of chemotherapy drugs

A new mechanism to inhibit proteasomes, protein complexes that are a target for cancer therapy, is the topic of an article published in the journal Chemistry & Biology.

10 Sep 2014

New potential therapeutic targets for treatment of pulmonary arterial hypertension

Two new potential therapeutic targets for the treatment of pulmonary arterial hypertension, a deadly disease marked by high blood pressure in the lungs, have been identified by researchers at the University of Illinois at Chicago.

9 Sep 2014

Combination miRNA therapy offers promising therapeutic avenue for non-small-cell lung cancer

Micro RNAs (miRNA) have recently emerged as key therapeutic agents against cancers and are actively being evaluated in pre-clinical models of various cancers as well as in human clinical trials.

8 Sep 2014

Synthetic announces positive results from final preclinical toxicology study of SYN-004

Synthetic Biologics, Inc., a developer of novel anti-infective biologic and drug candidates targeting specific pathogens that cause serious infections and diseases, announced today positive results from its final preclinical toxicology study of SYN-004.

2 Sep 2014

Internal production of hydrogen peroxide can lead cells to exit cell cycle and become senescent

What happens inside cells when they detect the activation of a cancer-inducing gene? Sometimes, cells are able to signal internally to stop the cell cycle. Such cells are able to enter, at least for a time, a protective non-growth state.

30 Aug 2014

Study compares FK506 and rapamycin for Schwann cell migration, peripheral nerve regeneration

FK506 possesses a well-studied neuroregenerative effect, stimulating neurite extension in the presence of nerve growth factor in vitro, and enhancing nerve regeneration following nerve crush injury and isografting.

30 Aug 2014

New technology holds potential to identify cardiac disease using video monitoring

To the careful observer, a person's face has long provided insight into what is going on beneath the surface. Now, with the assistance of a web camera and software algorithms, the face can also reveal whether or not an individual is experiencing atrial fibrillation, a treatable but potentially dangerous heart condition.

29 Aug 2014

UT Southwestern faculty awarded CPRIT grants to combat cancer

UT Southwestern Medical Center faculty have received 19 grants totaling more than $26 million from the Cancer Prevention and Research Institute of Texas to expand cancer screenings, investigate the effectiveness and viability for cancer therapies and radiation treatments, conduct research into cancer biology, and recruitment.

29 Aug 2014

Proliferation News and Research

Curcumin, cancer-inhibiting peptides show promise in slowing progression of mesothelioma

Longer telomeres increase melanoma risk

Rosuvastatin promotes bone growth in mice with achondroplasia symptoms

Disrupting cancer regulator MYC: an interview with Professor Kim Janda

Ramucirumab effective second-line option for NSCLC

Specific blood test could indicate neoadjuvant treatment regimens for ESCC patients

Blocking bacteria's access to iron: an interview with Dr. Laxminarayana Devireddy

Collaborative study takes important step toward finding targeted treatments for bladder cancer

Researchers find learning and memory components of neurofibromatosis using zebrafish model

Scientists crack genetic code of liver fluke parasite

Viewpoints: Medicaid and assets; a surprising look at narrow networks

Growth factors present in human breast milk may protect against intestinal damage

Researchers pave way for development of new generation of chemotherapy drugs

New potential therapeutic targets for treatment of pulmonary arterial hypertension

Combination miRNA therapy offers promising therapeutic avenue for non-small-cell lung cancer

Synthetic announces positive results from final preclinical toxicology study of SYN-004

Internal production of hydrogen peroxide can lead cells to exit cell cycle and become senescent

Study compares FK506 and rapamycin for Schwann cell migration, peripheral nerve regeneration

New technology holds potential to identify cardiac disease using video monitoring

UT Southwestern faculty awarded CPRIT grants to combat cancer

Industry Focus eBook - Cell biology (5th edition) eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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