Cytotoxicity News and Research

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Algae found to inhibit SARS-CoV-2 infection in vitro

A new study demonstrated that dry algal powders inhibit SARS-CoV-2 in vitro.

25 Mar 2022

Angiotensin-converting enzyme 2 allosteric binders found to be effective against SARS-CoV-2

Researchers reported a hybrid approach comprising computational models and high throughput screening to discover allosteric ACE2 binders inhibiting viral replication without interrupting ACE2 renal, pulmonary, immune, and cardiovascular functions.

22 Mar 2022

Study explores novel antiviral activity of PAD inhibitors against human beta-coronaviruses HCoV-OC43 and SARS-CoV-2

In a new study, researchers aimed to determine if peptidyl-arginine deiminases inhibitors may be used as a novel class of host-targeting antivirals against human coronaviruses.

21 Mar 2022

The importance of the endosomal pathway for SARS-CoV-2 entry

Researchers demonstrated that combined inhibition of cell-surface-based and endosomal pathways completely blocked SARS-CoV-2 entry into mammalian cells.

21 Mar 2022

Study unveils several natural marine products as potential agents against SARS-CoV-2

A recent study, published in the Journal of Natural Products of the American Chemical Society and American Society of Pharmacognosy, highlighted three natural marine products as potent inhibitors of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – without any apparent toxic effects for human lung cells.

21 Mar 2022

Novel fusion inhibitor blocks SARS-CoV-2 spike-mediated cell-cell fusion

Researchers constructed a novel fusion inhibitor−based recombinant protein, referred to as 5−Helix, to block SARS-CoV-2 spike-mediated cell-cell fusion.

17 Mar 2022

Multisystem inflammatory syndrome as a late complication in COVID-19 infected children

Researchers determined the immune signature of the multisystem inflammatory syndrome in children among hospitalized children diagnosed with SARS‐CoV‐2 infection.

16 Mar 2022

Placenta found to demonstrate anti-oxidant activity against COVID-19 in full-term pregnancy

Researchers assessed the placental anti-oxidant response in the third trimester of pregnancy against SARS-CoV-2 infections.

16 Mar 2022

Efficient inactivation of SARS-CoV-2 on N95 masks by an antimicrobial coating

In a recent study, researchers demonstrate that Goldshield75 coating inactivated SARS-CoV-2 on N95 filters and masks.

14 Mar 2022

Durable selenium nanoparticle fabrics with antiviral and antibacterial properties

Researchers graft SeNPs on polyester fabric through a flat screen-printing technique and observed their antimicrobial activity.

8 Mar 2022

MUSC study sheds light on better ways to prevent and treat colorectal cancer

An MUSC Hollings Cancer Center study sheds light on better ways to prevent and treat colorectal cancer, which often is found at advanced stages when it's much harder to treat.

28 Feb 2022

Noncovalent protease inhibitors against SARS-CoV-2 and other coronaviruses

In a new study published in ACS Infectious Diseases journal, scientists biochemically and structurally evaluated the PLpro from a subgroup 2b bat coronavirus, BtSCoV-Rf1.2004, to identify unique structural features or enzymatic biases of the subgroup 2b.

28 Feb 2022

Omicron neutralizing titers after third BNT162b2 dose are persistent

The new study, published in the journal Cell Host and Microbe, also finds that the neutralization against Omicron remains robust at four months after the third dose of the BNT162b2 vaccine.

22 Feb 2022

Ensitrelvir, a novel SARS-CoV-2 antiviral

S-217622 reduces the viral load and help alleviate the severity of SARS-CoV-2 in infected hamsters.

17 Feb 2022

mRNA COVID-19 vaccine shown to induce afucosylated antibodies in individuals without prior SARS-CoV-2 exposure

New study findings reveal that the level of afucosylated anti-spike antibodies increases transiently in infection-naïve individuals after the first COVID-19 vaccine dose.

17 Feb 2022

Superior immune response in vaccinated after infection with Omicron compared to unvaccinated

In a recent study posted to the medRxiv* preprint server, researchers evaluated the cross-reactivity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant-triggered neutralization and fragment crystallizable (Fc) effector functions between coronavirus disease 2019 (COVID-19)-vaccinated and unvaccinated individuals in South Africa.

16 Feb 2022

Nitazoxanide shows promise for COVID-19 treatment in animal model

In a recent study posted to the bioRxiv* pre-print server, researchers demonstrated that Nitazoxanide (NTZ), an oral drug, broadly inhibits replication of several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) in preclinical models of infection.

13 Feb 2022

New approach to CAR T-cell therapy for B-cell cancers triples the targeted antigens on cancer cells

Researchers at University Hospitals Seidman Cancer Center and Case Western Reserve University have developed a novel approach to chimeric antigen receptor (CAR) T-cell therapy for B-cell cancers that triples the targeted antigens on cancer cells – a "back up" approach that promises to greatly reduce the potential for antigen escape currently found in CAR T therapies that solely target CD19.

2 Feb 2022

Development of synthetic molecules that can bridge T cells with SARS-CoV-2 infected cells

Scientists have recently used synthetic biology to design primary human CD8 T cells to express Spike protein-specific chimeric antigen receptors (ACE2 CAR or anti-Spike CAR).

25 Jan 2022

PFAS found in high levels in anti-fogging sprays

We speak to Professor Heather Stapleton and Dr. Nicholas Herkert about their latest research that led to the discovery of high levels of PFAS in anti-fogging sprays.

24 Jan 2022

Cytotoxicity News and Research

Algae found to inhibit SARS-CoV-2 infection in vitro

Angiotensin-converting enzyme 2 allosteric binders found to be effective against SARS-CoV-2

Study explores novel antiviral activity of PAD inhibitors against human beta-coronaviruses HCoV-OC43 and SARS-CoV-2

The importance of the endosomal pathway for SARS-CoV-2 entry

Study unveils several natural marine products as potential agents against SARS-CoV-2

Novel fusion inhibitor blocks SARS-CoV-2 spike-mediated cell-cell fusion

Multisystem inflammatory syndrome as a late complication in COVID-19 infected children

Placenta found to demonstrate anti-oxidant activity against COVID-19 in full-term pregnancy

Efficient inactivation of SARS-CoV-2 on N95 masks by an antimicrobial coating

Durable selenium nanoparticle fabrics with antiviral and antibacterial properties

MUSC study sheds light on better ways to prevent and treat colorectal cancer

Noncovalent protease inhibitors against SARS-CoV-2 and other coronaviruses

Omicron neutralizing titers after third BNT162b2 dose are persistent

Ensitrelvir, a novel SARS-CoV-2 antiviral

mRNA COVID-19 vaccine shown to induce afucosylated antibodies in individuals without prior SARS-CoV-2 exposure

Superior immune response in vaccinated after infection with Omicron compared to unvaccinated

Nitazoxanide shows promise for COVID-19 treatment in animal model

New approach to CAR T-cell therapy for B-cell cancers triples the targeted antigens on cancer cells

Development of synthetic molecules that can bridge T cells with SARS-CoV-2 infected cells

PFAS found in high levels in anti-fogging sprays

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