Metabolic Disease News and Research

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Penn researchers identify genome-wide changes caused by high-fat diet

By comparing two strains of mice -- one that becomes obese and diabetic on a high-fat diet and another resistant to a high-fat regimen -- researchers from the Perelman School of Medicine at the University of Pennsylvania identified genome-wide changes caused by a high-fat diet.

8 Mar 2017

Scientists track 'guardian immune cells' to uncover mechanics underlying inflammation and obesity

Scientists have uncovered the physiological mechanics underlying inflammation and obesity by tracking the actions of 'guardian immune cells' in response to changes in diet.

2 Mar 2017

BIDMC review focuses on neural circuitry of wakefulness and sleep

Sleep remains an enduring biological mystery with major clinical relevance, according to a review by clinician-researcher Thomas Scammell, MD, of Beth Israel Deaconess Medical Center (BIDMC) and colleagues.

23 Feb 2017

Mice study provides clues to how genetic variations in gut microbes influence metabolic disease

The community of microorganisms that resides in the gut, known as the microbiome, has been shown to work in tandem with the genes of a host organism to regulate insulin secretion, a key variable in the onset of the metabolic disease diabetes.

17 Feb 2017

Study shows way to counteract junk-food eating cycle

People are easily pulled into binge culture's quick-fix obsession with junk-food. But, according to a study published in Frontiers in Behavioral Neuroscience, they might just as easily be able to pull themselves out of it.

27 Jan 2017

Body shaming may contribute to increased health risks

Body shaming is a pervasive form of prejudice, found in cyber bullying, critiques of celebrities' appearances, at work and school, and in public places for everyday Americans.

27 Jan 2017

Islets from rat-grown mouse pancreases can help reverse disease in diabetic mice

Mouse pancreases grown in rats generate functional, insulin-producing cells that can reverse diabetes when transplanted into mice with the disease, according to researchers at the Stanford University School of Medicine and the Institute of Medical Science at the University of Tokyo.

25 Jan 2017

Exposure to insecticides that mimic melatonin could put people at higher risk for diabetes

Synthetic chemicals commonly found in insecticides and garden products bind to the receptors that govern our biological clocks, University at Buffalo researchers have found.

19 Jan 2017

Childhood obesity starts in the womb?

There is incontrovertible evidence that some harmful drugs and toxins can affect lifelong health. For example, if women take certain drugs in pregnancy, such as thalidomide, there are well documented effects on lifelong health. These have obvious and dramatic effects on the child...

11 Jan 2017

Detecting inflammation in diabetic patients

As well as presenting with high blood glucose, diabetic patients have chronic low-grade inflammation, which can be measured by a range of inflammatory markers such as so-called high-sensitive CRP, TNFa and IL-6 as well as a full blood cell count.

7 Dec 2016

Short sleepers likely to consume significantly more sugary caffeinated drinks, study finds

People who sleep five or fewer hours a night are likely to also drink significantly more sugary caffeinated drinks, such as sodas and energy drinks, according to a new study of more than 18,000 adults led by UC San Francisco scientists.

9 Nov 2016

Researchers shed light on how success of gut microbiome treatments may depend on genetics

Our gut microbiomes--the bacteria that live in our digestive tract--play major roles in our health. Scientists around the world are studying therapies that manipulate the microbiome, including probiotics (such as live bacterial cultures in yogurt), prebiotics (edible fibers meant to promote beneficial bacteria), antibiotics and transplants of microbes from healthy people.

7 Nov 2016

Regular consumption of dietary emulsifiers promotes colorectal cancer in mice

Emulsifiers, which are added to most processed foods to aid texture and extend shelf life, can alter intestinal bacteria in a manner that promotes intestinal inflammation and colorectal cancer, according to a new study.

7 Nov 2016

Benefit and harm of tandem mass spectrometry screening for tyrosinaemia type 1 remain unclear

Tyrosinaemia type 1 is a rare, hereditary metabolic disease that, if left untreated, can already lead to serious liver and kidney damage in infancy.

25 Oct 2016

IBRI receives $1 million research grant from Cook Medical to support growth of Institute

The Indiana Biosciences Research Institute (IBRI) today announced a $1 million research grant from Cook Medical to support the next phase of growth for the Institute dedicated to discovery science and applied research leading to innovation targeting cardio-metabolic disease, diabetes, and poor nutrition.

20 Oct 2016

Depriving deadly brain cancer cells of cholesterol causes tumor regression in mouse models

Researchers at University of California San Diego School of Medicine, Ludwig Institute for Cancer Research and The Scripps Research Institute, with colleagues in Los Angeles and Japan, report that depriving deadly brain cancer cells of cholesterol, which they import from neighboring healthy cells, specifically kills tumor cells and caused tumor regression and prolonged survival in mouse models.

13 Oct 2016

NTU scientists develop new test kit for rapid detection of inflammation in diabetic patients

Scientists from Nanyang Technological University, Singapore have developed a new kit that will allow doctors to find out within minutes if diabetic patients are suffering from inflammation.

27 Sep 2016

Study provides insights into how insulin resistance, diabetes begin

Does eating too much sugar cause type 2 diabetes? The answer may not be simple, but a study published Sept. 26 in the Journal of Clinical Investigation adds to growing research linking excessive sugar consumption -- specifically the sugar fructose -- to a rise in metabolic disease worldwide.

26 Sep 2016

Wayne State receives NIH funding to advance brain aging research

Wayne State University has received a $3.6 million grant from the National Institute on Aging of the National Institutes of Health for a project that will advance knowledge of brain aging, its relation to cognitive performance and the role of common vascular and metabolic risk factors in shaping the trajectories of aging.

15 Sep 2016

New study finds link between PTSD and metabolic syndrome, cortical thickness

Metabolic syndrome, a cluster of cardiometabolic conditions, may be a biological mechanism linking posttraumatic stress disorder (PTSD) to structural brain abnormalities, according to a new study in Biological Psychiatry.

31 Aug 2016