Central Nervous System News and Research

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GSK, Angiochem to develop and commercialize LSD treatments

Angiochem announced today a global collaboration with GlaxoSmithKline (GSK) to discover, develop and commercialize treatments for lysosomal storage diseases.

27 Feb 2012

Chronic pain patients at high-risk for comorbid substance abuse benefit from 3-week program

Research presented at the American Academy of Pain Medicine's 28th Annual Meeting shows that substance use education incorporated into a cognitive behavioral rehabilitation programming is effective to improve pain and function for the chronic pain patient at high-risk for comorbid substance abuse.

27 Feb 2012

Rosemary aroma may improve cognitive performance

Hailed since ancient times for its medicinal properties, we still have a lot to learn about the effects of rosemary. Now researchers writing in Therapeutic Advances in Psychopharmacology, published by SAGE, have shown for the first time that blood levels of a rosemary oil component correlate with improved cognitive performance.

26 Feb 2012

UA researchers identify the likely culprit of epilepsy

Only 10 years ago, deciphering the genetic information from one individual in a matter of weeks to find a certain disease-causing genetic mutation would have been written off as science fiction. It was the time of the Human Genome Project, and it had taken armies of sequencing robots working around the clock for almost a decade to unravel the complete sequence of the human genetic code - referred to as the genome - by churning out the DNA alphabet letter by letter.

24 Feb 2012

AAN, National MS Society to honor Cleveland Clinic researcher with John Dystel Prize

The American Academy of Neurology and the National Multiple Sclerosis Society are awarding the 2012 John Dystel Prize for MS Research to Richard M. Ransohoff, MD, with the Cleveland Clinic. Ransohoff, a member of the American Academy of Neurology and Associate Editor of Neurology, the Academy's medical journal, will receive the award at the Academy's 64th Annual Meeting in New Orleans, April 21-28, 2012.

22 Feb 2012

FDA grants orphan-drug designation to Arno's AR-42 for treatment of meningioma, schwannoma

Arno Therapeutics, Inc. announced today that its investigational compound, AR-42, has been granted orphan-drug designation by the U.S. Food and Drug Administration for the treatment of meningioma and schwannoma of the central nervous system.

21 Feb 2012

S1 submits Lorexys IND application for HSDD and Female Sexual Dysfunction treatment

S1 Pharmaceuticals, Inc. (S1) announced today that it has submitted its Investigational New Drug (IND) application to the U.S. Food and Drug Administration for Phase I-b clinical studies of SIP-104 (Lorexys). Lorexys is the Company's lead drug candidate for the treatment of Hypoactive Sexual Desire Disorder (HSDD) and Female Sexual Dysfunction (FSD).

21 Feb 2012

Scientists discover molecular mechanism behind MS relapses

Scientists have discovered a molecular mechanism that could help explain how multiple sclerosis (MS) and other autoimmune diseases can be exacerbated by the onset of an infection.

18 Feb 2012

New, under-recognized, much more potent variant of common bacterium

University at Buffalo researchers are expressing concern about a new, under-recognized, much more potent variant of a common bacterium that has surfaced in the U.S.

18 Feb 2012

Study examines mercury exposure in pregnant women

A new study published by researchers at SUNY Downstate Medical Center's School of Public Health assesses mercury levels in pregnant women and examines dietary and environmental sources of exposure to mercury. The research, which focuses on an urban immigrant community, examined risk factors that may be associated with elevated mercury levels, measured through urine and cord blood samples.

18 Feb 2012

UB researchers express concern about a new variant of Klebsiella pneumoniae

University at Buffalo researchers are expressing concern about a new, under-recognized, much more potent variant of a common bacterium that has surfaced in the U.S.

18 Feb 2012

New information about IL-6 protein's role in development of neurological disorders

A UT Dallas study is revealing new information about a key protein's role in the development of epilepsy, autism and other neurological disorders. This work could one day lead to new treatments for the conditions.

15 Feb 2012

New WSU model system focuses on causes of everyday MS symptoms

Annoying, frustrating symptoms like difficulty hearing or remembering things can complicate everyday living for multiple sclerosis (MS) patients, but most research to date has focused on the disease's less frequent but more debilitating consequences.

15 Feb 2012

Scientists identify and describe molecular mechanism behind holoprosencephaly

Researchers of the Max Delbr-ck Center for Molecular Medicine (MDC) Berlin-Buch have now identified and described a molecular mechanism underlying the most common malformation of the brain in humans. In holoprosencephaly (HPE), the forebrain (prosencephalon) is only incompletely formed.

14 Feb 2012

Erasing neuronal memories may help control persistent pain

For some, the pain is so great that they can't even bear to have clothes touch their skin. For others, it means that every step is a deliberate and agonizing choice. Whether the pain is caused by arthritic joints, an injury to a nerve or a disease like fibromyalgia, research now suggests there are new solutions for those who suffer from chronic pain.

13 Feb 2012

Benefits of long-term Kineret therapy in people with NOMID

A new study shows that Kineret (anakinra), a medication approved for the treatment of rheumatoid arthritis, is effective in stopping the progression of organ damage in people with neonatal-onset multisystem inflammatory disease.

13 Feb 2012

Study looks at link between delivery time and outcomes for infants with birth defects

Weekday delivery is no better than night or weekend delivery for infants with birth defects, according to a new study presented today at The Pregnancy Meeting, the Society for Maternal-Fetal Medicine's annual conference. The finding is good news for all parties - moms, babies and healthcare teams - and suggests that this high-risk population of women should deliver when their bodies are ready to deliver, regardless of the day or time.

13 Feb 2012

New evidence for role of the brain in obesity

Researchers at the University of Turku and Aalto University have now found new evidence for the role of the brain in obesity. The researchers measured the functioning brain circuits involved in with multiple brain imaging methods.

10 Feb 2012

Gene therapy to promote remyelination in mouse model of MS

Our bodies are full of tiny superheroes-antibodies that fight foreign invaders, cells that regenerate, and structures that ensure our systems run smoothly. One such structure is myelin-a material that forms a protective, insulating cape around the axons of our nerve cells so that they can send signals quickly and efficiently. But myelin, and the specialized cells called oligodendrocytes that make it, become damaged in demyelinating diseases like multiple sclerosis (MS), leaving neurons without their myelin sheaths.

10 Feb 2012

New cERD method can detect RNAi activity in biological fluids

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that its scientists have discovered a novel method for monitoring RNAi activity in blood samples, representing a potential major advance for future development of RNAi therapeutics, other therapeutic modalities, and diagnostics.

10 Feb 2012