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Sleep deprivation can impact outcome of stem cell transplantation, study finds

Drowsy mice make poor stem cell donors, according to a new study by researchers at the Stanford University School of Medicine.

15 Oct 2015

Bio-molecules present in human breast milk can help resolve inflammation, combat infection

Human breast milk, which provides essential nutrients and antibodies to newborns, has long been known to play an important role in infant development and the immune system. In a new study published in Mucosal Immunology, researchers from Brigham and Women's Hospital report that human breast milk serves as a reservoir for bio-molecules that help to resolve inflammation and combat infection.

15 Oct 2015

Researchers link organ transplant drug to rise in rare lymphoma

A study led by Johns Hopkins researchers has linked the immunosuppressive drug mycophenolate mofetil (MMF) to an increased risk of central nervous system (CNS) lymphoma in solid organ transplant patients. But the same study also found that another class of immunosuppressive drugs, called calcineurin inhibitors (CNIs), given alone or in combination with MMF, appears to protect transplant patients against this rare form of lymphoma.

15 Oct 2015

Notch activation determines signals necessary to generate hematopoietic stem cells in laboratory

An international study led by researchers from IMIM (Hospital del Mar Medical Research Institute) published in the journal Nature Communications has revealed that the intensity or efficiency of the activation of a protein called Notch, which is involved in the different phases of embryonic development, determines the fate of cells, i.e. if cells will form the aorta artery or blood (hematopoietic) stem cells. For artery cells, many Notch molecules need to be activated, whereas for hematopoietic cells many fewer are needed.

14 Oct 2015

Sleep apnea associated with evidence of early heart injury in women

Risk factors for obstructive sleep apnea (OSA) and the development of subsequent cardiovascular (CV) complications differ by sex, but it is not clear from prior research whether the effects of sleep apnea on heart disease is similar for men and women.

13 Oct 2015

DePuy Synthes Trauma announces U.S. launch of new biologic implant for trauma-related extremity procedures

DePuy Synthes Trauma announced today the U.S. launch of CONFORM Flex with Q-PACK Technology, the only pre-hydrated demineralized cancellous bone tissue matrix designed for use in trauma-related extremity procedures, including fusion, and for filling bone voids.

13 Oct 2015

Loyola University successfully performs double-lung transplant in patient with debilitating lung disease

Before he developed a debilitating lung disease, outdoorsman Michael Olson had taken 57 canoe and fishing trips to Canada.

13 Oct 2015

Scientists engineer stem cells to better understand mechanisms behind leukemia

Scientists engineered stem cells to better understand the mechanisms behind a form of leukemia caused by changes in a key gene, according to a study led by Mount Sinai researchers and published online today in the journal Cell Reports.

9 Oct 2015

Light-chain amyloidosis patients treated with high-dose chemo and stem cell transplantation have long-term survival

Patients with Light-chain (AL) amyloidosis who are treated with high-dose chemotherapy (melphalan) and autologous (one's own) stem cell transplantation (HDM/SCT) have the greatest success for long-term survival.

9 Oct 2015

NIBIB-supported bioengineers work to reduce platelet activation and clotting in patients with VADs

A team of NIBIB-supported bioengineers, aerospace scientists, and cardiovascular clinicians are improving the function of the thousands of life-saving ventricular assist devices (VADs) implanted in advanced heart failure patients each year.

8 Oct 2015

Half-matched donor bone marrow transplant just as good as full match, new study shows

Bone marrow transplantation is a life-saving therapy for many patients with blood cancers like leukemias and lymphomas. Currently, the gold standard blood-generating stem cells are obtained from a donor, a sibling, with a perfect match to the patient in order to minimize the chance of rejection and other complications. However, not all patients will have a perfectly matched sibling. Some cancer centers have begun to explore whether half-matched donors might work just as well.

8 Oct 2015

Nurses who work with organ transplant patients experience high levels of emotional exhaustion

More than half of nurses who work with organ transplant patients in the United States experience high levels of emotional exhaustion, a primary sign of burnout, according to a study published by researchers at Henry Ford Hospital.

7 Oct 2015

Researchers explore how common genetic mutation influences effects of taking melatonin close to mealtime

Researchers from Brigham and Women's Hospital and the University of Murcia, Spain, have shed new light on why people who carry a common genetic mutation may be more at risk for developing type 2 diabetes. By carefully studying healthy subjects, researchers were able to chart the effect of melatonin supplements on blood sugar control.

7 Oct 2015

World Scientific publishes new book that covers all aspects of cancer care

Cervical, uterine and ovarian cancers are among the most common cancers affecting women, with a total of 1,087,000 new cases diagnosed worldwide in 2012.

1 Oct 2015

HLA-DPB1 regulatory region genotype predicts acute GVHD

Analysis of a HLA-DPB1 regulatory region variant has shed light on the risk of acute graft-versus-host disease in patients undergoing haematopoietic cell transplantation from an unrelated donor.

1 Oct 2015

University of Michigan-led team performs first kidney transplants in Ethiopia

A University of Michigan-led team performed the first kidney transplants in Ethiopia last week, after spending more than two years to help establish a transplant center in the African country.

30 Sep 2015

Matchmaker Exchange platform launched for uncovering rare disease genes

In a special issue of Human Mutation, a team including investigators at Brigham and Women's Hospital has announced the launch of the Matchmaker Exchange - a way for the rare disease community to share information and find new connections. Matchmaker Exchange connects databases of genetic information and symptoms that physicians and investigators can "match" with a patient's rare disease.

25 Sep 2015

Hyperbaric oxygen therapy improves outcomes of umbilical cord blood transplant patients

For the past 27 years, cord blood transplants have been a life-saving treatment option for thousands of people with leukemia, non-Hodgkins lymphoma, Hodgkins disease and myelodysplastic disorders. Cord blood helps replace cancerous blood cells and replenish a patient's own bone marrow and immune system. Even with its success, researchers are continually looking for ways to improve the transplant process and increase cure rates.

24 Sep 2015

Researchers extend innovative research towards a cure for type I diabetes

Associate Professor Shane Grey, of Sydney's Garvan Institute of Medical Research, together with collaborators from the Westmead Millennium Institute for Medical Research and the Children's Hospital at Westmead, have been awarded $3.3 million to extend their innovative research towards a cure for type I diabetes.

23 Sep 2015

Study demonstrates potential of FCPCs as new source for cartilage regeneration

The self-repair of injured cartilage is difficult for several reasons, foremost of which is the lack of blood supply to the tissue. Therapeutic efforts aimed at cartilage repair are often not optimal. Surgical repair techniques often lead to the formation of fibrocartilage, which is weaker and less durable. Although cell transplantation aimed at cartilage repair has been carried out using mesenchymal stem cells (MSCs), varying outcomes have resulted, despite the propensity of MSCs to proliferate and differentiate.

23 Sep 2015

Transplant News and Research

Sleep deprivation can impact outcome of stem cell transplantation, study finds

Bio-molecules present in human breast milk can help resolve inflammation, combat infection

Researchers link organ transplant drug to rise in rare lymphoma

Notch activation determines signals necessary to generate hematopoietic stem cells in laboratory

Sleep apnea associated with evidence of early heart injury in women

DePuy Synthes Trauma announces U.S. launch of new biologic implant for trauma-related extremity procedures

Loyola University successfully performs double-lung transplant in patient with debilitating lung disease

Scientists engineer stem cells to better understand mechanisms behind leukemia

Light-chain amyloidosis patients treated with high-dose chemo and stem cell transplantation have long-term survival

NIBIB-supported bioengineers work to reduce platelet activation and clotting in patients with VADs

Half-matched donor bone marrow transplant just as good as full match, new study shows

Nurses who work with organ transplant patients experience high levels of emotional exhaustion

Researchers explore how common genetic mutation influences effects of taking melatonin close to mealtime

World Scientific publishes new book that covers all aspects of cancer care

HLA-DPB1 regulatory region genotype predicts acute GVHD

University of Michigan-led team performs first kidney transplants in Ethiopia

Matchmaker Exchange platform launched for uncovering rare disease genes

Hyperbaric oxygen therapy improves outcomes of umbilical cord blood transplant patients

Researchers extend innovative research towards a cure for type I diabetes

Study demonstrates potential of FCPCs as new source for cartilage regeneration

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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