Cell Death News and Research

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Scientists receive $2.2M grant to improve treatments for immune disorders, inflammatory diseases

Scientists from the Walter and Eliza Hall Institute have been awarded more than $2.2 million from the Australian Research Council (ARC) to improve treatments for immune disorders and inflammatory diseases.

16 Nov 2013

Study offers clearer explanation of the role of FOX01 molecule in wound-healing process

Skin provides a first line of defense against viruses, bacteria and parasites that might otherwise make people ill. When an injury breaks that barrier, a systematic chain of molecular signaling launches to close the wound and re-establish the skin's layer of protection.

16 Nov 2013

Annexin A5 protein may have therapeutic potential for treatment of sepsis

Sepsis is the leading cause of in-hospital death and there is no specific treatment for it. Now, research led by Dr. Qingping Feng of Western University (London, Canada) suggests a protein called recombinant human annexin A5 may have therapeutic potential for the treatment of this disease. The paper is published in advance, online in Critical Care Medicine.

15 Nov 2013

Stem cells from Wolfram syndrome patients used to elucidate beta-cell failure pathway in diabetes

Scientists from the New York Stem Cell Foundation Research Institute and Columbia University Medical Center have used stem cells created from the skin of patients with a rare form of diabetes—Wolfram syndrome—to elucidate an important biochemical pathway for beta-cell failure in diabetes. The findings by Linshan Shang and colleagues were published today in Diabetes.

13 Nov 2013

'Quitting cold turkey' can lead to mental decline, shows study

Can quitting drugs without treatment trigger a decline in mental health? That appears to be the case in an animal model of morphine addiction. Georgetown University Medical Center researchers say their observations suggest that managing morphine withdrawal could promote a healthier mental state in people.

13 Nov 2013

Researchers discover powerful mechanism that keeps white blood cells from going rogue

The immune system is a double-edged sword. While its primary role is to fight infections, it can also become overactive, leading to problems like allergies and autoimmune diseases.

13 Nov 2013

Novel discovery of RUNX3 gene provides new insights on defence mechanism against lung cancer

Novel discovery relating to the function of RUNX3 gene provides new insights on human defence mechanism against early stages of lung cancer development

13 Nov 2013

Merck Serono signs co-development and commercialization agreement for BeiGene-290

Merck Serono, the biopharmaceutical division of Merck, today announced that a global licensing, co-development, and commercialization agreement for BeiGene-290 has been signed with BeiGene Co., Ltd., a biotech research and development company in Beijing, China.

13 Nov 2013

XTANDI now accepted for use within NHS Scotland for treatment of adult men with mCRPC

The Scottish Medicines Consortium, which advises NHS Scotland on prescribing new treatments, announced today that XTANDI (enzalutamide) is accepted for unrestricted use within NHS Scotland for the treatment of adult men with metastatic castration-resistant prostate cancer whose disease has progressed on or after docetaxel therapy.

13 Nov 2013

Researchers discover new pathway for treating allergic diseases

A collaboration among researchers in Israel and the United States has resulted in the discovery of a new pathway that has broad implications for treating allergic diseases - particularly eosinophil-associated disorders.

12 Nov 2013

GW Pharmaceuticals starts Phase 1b/2a clinical trial for Recurrent Glioblastoma Multiforme

GW Pharmaceuticals plc a biopharmaceutical company focused on discovering, developing and commercializing novel therapeutics from its proprietary cannabinoid product platform, announced today it has commenced a Phase 1b/2a clinical trial for the treatment of Recurrent Glioblastoma Multiforme.

11 Nov 2013

FOXO3 transcription factor may protect against alcohol-induced liver injury

New data suggest that the transcription factor FOXO3 may protect against alcohol-induced liver injury. Researchers determined that alcohol given to mice deficient in FOXO3 caused severe liver injury resembling human alcoholic hepatitis.

11 Nov 2013

Researchers reveal that reduction in mitochondrial DNA may lead to metastasis of breast cancer cells

For years, scientists have observed that tumor cells from certain breast cancer patients with aggressive forms of the disease contained low levels of mitochondrial DNA. But, until recently, no one was able to explain how this characteristic influenced disease progression.

11 Nov 2013

Peptide from cow's milk exhibits potent anticancer capability against human stomach cancer cell cultures

New research from a team of researchers in Taiwan indicates that a peptide fragment derived from cow's milk, known as lactoferricin B25 (LFcinB25), exhibited potent anticancer capability against human stomach cancer cell cultures.

8 Nov 2013

Findings raise prospects for new therapies to protect heart from progressive disease

Some of the most commonly prescribed drugs for the treatment of heart failure are beta-blockers and nitrates, which help to relax blood vessels and decrease the heart's workload. The drugs were thought to produce those effects through distinct molecular pathways, but according to a new study led by scientists at Temple University School of Medicine, both types of drugs may help the failing heart by counteracting the effects of an enzyme known as GRK2.

8 Nov 2013

Levels of BPA in components of dialysis machines may be toxic to patients' immune cells

Levels of bisphenol A (BPA) in components of dialysis machines may be toxic to the immune cells circulating in kidney failure patients' blood, according to a study that will be presented at ASN Kidney Week 2013 November 5-10 at the Georgia World Congress Center in Atlanta, GA.

8 Nov 2013

Lactoferricin B25 derived from cow's milk shows promise for treatment of gastric cancer

8 Nov 2013

Inhibition of heart protein reduces damage from heart attack, say researchers

The stop and start of blood flow to the heart during and after a heart attack causes severe damage to heart cells, reducing their capacity to function and potentially causing their death.

7 Nov 2013

Researchers discover relationship between TGFb signalling pathways and CXCR4 in HCC

Researchers from the Biological clues of the invasive and metastatic phenotype group of the Bellvitge Biomedical Research Institute (IDIBELL) led by Isabel Fabregat have discovered the relationship between the TGFb signalling pathways and CXCR4 in hepatocellular carcinoma (HCC) .

7 Nov 2013

New drug combination therapy effectively kills cancer cells

Results from a recent preclinical study have shown that a new drug combination therapy being developed at Virginia Commonwealth University Massey Cancer Center effectively killed colon, liver, lung, kidney, breast and brain cancer cells while having little effect on noncancerous cells. The results lay the foundation for researchers to plan a future phase 1 clinical trial to test the safety of the therapy in a small group of patients.

6 Nov 2013

Cell Death News and Research

Scientists receive $2.2M grant to improve treatments for immune disorders, inflammatory diseases

Study offers clearer explanation of the role of FOX01 molecule in wound-healing process

Annexin A5 protein may have therapeutic potential for treatment of sepsis

Stem cells from Wolfram syndrome patients used to elucidate beta-cell failure pathway in diabetes

'Quitting cold turkey' can lead to mental decline, shows study

Researchers discover powerful mechanism that keeps white blood cells from going rogue

Novel discovery of RUNX3 gene provides new insights on defence mechanism against lung cancer

Merck Serono signs co-development and commercialization agreement for BeiGene-290

XTANDI now accepted for use within NHS Scotland for treatment of adult men with mCRPC

Researchers discover new pathway for treating allergic diseases

GW Pharmaceuticals starts Phase 1b/2a clinical trial for Recurrent Glioblastoma Multiforme

FOXO3 transcription factor may protect against alcohol-induced liver injury

Researchers reveal that reduction in mitochondrial DNA may lead to metastasis of breast cancer cells

Peptide from cow's milk exhibits potent anticancer capability against human stomach cancer cell cultures

Findings raise prospects for new therapies to protect heart from progressive disease

Levels of BPA in components of dialysis machines may be toxic to patients' immune cells

Lactoferricin B25 derived from cow's milk shows promise for treatment of gastric cancer

Inhibition of heart protein reduces damage from heart attack, say researchers

Researchers discover relationship between TGFb signalling pathways and CXCR4 in HCC

New drug combination therapy effectively kills cancer cells

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