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InvivoSciences, WUSTL to construct artificial tissue models for heart failure

The National Institutes of Health has awarded more than $2 million to a team of scientists from Washington University in St. Louis and InvivoSciences, a biotechnology startup with WUSTL roots, to construct artificial tissue models that will allow the rapid testing of new drugs for heart failure.

17 Jul 2012

Once-daily single-tablet HIV therapy developed

A single tablet containing four antiviral agents may be an effective initial once-daily therapy for adults infected with HIV, shows phase III clinical research.

16 Jul 2012

Athletes return to elite sport after hip reconstruction

Around three-quarters of elite athletes who undergo arthroscopic labral reconstruction of the hip successfully return to their sport at the same level of competition they were at prior to surgery, a review shows.

16 Jul 2012

Prostate cancer treatment regrets linked to comorbidity

Men with cardiovascular disease are significantly more likely to regret their prostate cancer treatment choice than men without this comorbidity and have an increased risk for adverse effects, US researchers warn.

16 Jul 2012

New surgical technique may repair common, painful hip condition in elite athletes

A common, painful hip condition in elite athletes may be able to be repaired with an improved surgical technique, according to researchers presenting their work at the American Orthopaedic Society for Sports Medicine's Annual Meeting in Baltimore, Maryland today.

16 Jul 2012

PRP therapy safe and effective method of treatment for athletes with cartilage tears

When it comes to treating cartilage tears in athletes, Platelet Rich Plasma (PRP) therapy is a safe and effective method of treatment, according to research presented today at the American Orthopaedic Society for Sports Medicine's (AOSSM) Annual Meeting in Baltimore.

16 Jul 2012

Rehabilitation after rotator cuff surgery may be partially to blame for high rates of failed healing

A new Hospital for Special Surgery study suggests that the current rehabilitation used for patients undergoing tendon-bone repairs such as rotator cuff repair may be partially to blame for the high rates of failed healing after surgery. Experiments in a rat model of this injury suggest that immobilizing the limb for four to six weeks after surgery, rather than quickly starting physical therapy, improves healing.

16 Jul 2012

Special issue of AIDS and Behavior looks at latest behavioral interventions research

HIV prevention must be better targeted, according to David Holtgrave from Johns Hopkins Bloomberg School of Public Health in the US, and colleagues. Health care professionals need a more detailed analysis and understanding of the interplay between HIV risk behavior, access to treatment and treatment success among those living with HIV. The authors discuss their proposed framework in a study in a special issue of Springer's journal AIDS and Behavior.

16 Jul 2012

Researchers link newly discovered gene mutations to ALS

Researchers have linked newly discovered gene mutations to some cases of the progressive fatal neurological disease amyotrophic lateral sclerosis - ALS, also known as Lou Gehrig's disease. Shedding light on how ALS destroys the cells and leads to paralysis, the researchers found that mutations in this gene affect the structure and growth of nerve cells.

16 Jul 2012

Psychotic depression now fulfills the criteria for a valid psychiatric syndrome

The number of studies reporting significant and clinically relevant differences between psychotic depression (PD) and non-PD has increased considerably over the past decades. This summary of the current evidence suggests that PD now fulfils the criteria for a valid psychiatric syndrome.

14 Jul 2012

Paper describes novel psychotherapeutic approach in a boy with Asperger's syndrome

This paper reports a stable improvement in social skills in a 15-year-old boy diagnosed with Asperger's syndrome (AS), after an outpatient treatment with Social Effectiveness Therapy for Children and Adolescents (SET-C), a specific and intensive type of social skill training. Its effectiveness should be further tested in randomized controlled and long-term follow-up studies.

14 Jul 2012

Call for more restricted opioid use

US experts call for more selective and cautious opioid prescribing for chronic noncancer pain in primary care, because of concerns over misuse of the drugs and continued uncertainty over when and for how long they should be prescribed.

13 Jul 2012

More reason to restrict hormone therapy during menopause

Researchers have found further evidence to show that menopausal hormone therapy increases the risk for high blood pressure in postmenopausal women.

13 Jul 2012

Adding functional skills training to CRT improves schizophrenia functioning

Adding functional skills training to cognitive remediation therapy significantly improves functional competence and real-world behavior in patients with schizophrenia, show study findings.

13 Jul 2012

Incident HF an ‘extreme high-risk’ condition

Patients have a markedly increased risk for stroke and death in the month following a new heart failure diagnosis, say researchers.

13 Jul 2012

Scientists isolate new type of energy-burning fat cell

Scientists at Dana-Farber Cancer Institute have isolated a new type of energy-burning fat cell in adult humans which they say may have therapeutic potential for treating obesity.

13 Jul 2012

OncoMed commences dosing in OMP-54F28 Phase I clinical trial for advanced solid tumor cancers

OncoMed Pharmaceuticals, Inc., a clinical-stage company developing novel therapeutics that target cancer stem cells, or tumor-initiating cells, today announced that patient dosing has begun in a Phase I clinical trial of OMP-54F28 in patients with advanced solid tumor cancers.

13 Jul 2012

Discovery sheds light on why human body is unable to fight off HIV infection

University of Washington researchers have made a discovery that sheds light on why the human body is unable to adequately fight off HIV infection.

13 Jul 2012

Cubist initiates CB-315 Phase 3 trial for Clostridium difficile-associated diarrhea

Cubist Pharmaceuticals, Inc. today announced the initiation of its pivotal Phase 3 studies evaluating the efficacy and safety of CB-315 in patients with Clostridium difficile-associated diarrhea, or CDAD, with enrollment of a patient in the first of two planned identical global trials.

13 Jul 2012

Heart disease risk in elderly could be lowered by drugs

More patients aged 75 and over should be prescribed drugs to help lower their risk of cardiovascular disease, a study published today on bmj.com suggests.

13 Jul 2012