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Combination of Zelboraf and immunotherapy increases tumor responses and survival in MM

Combining the recently approved BRAF inhibitor, Zelboraf with an engineered T cell immunotherapy to treat metastatic melanoma significantly increased tumor responses and survival in an animal model, researchers at UCLA's Jonsson Comprehensive Cancer Center have shown.

16 Aug 2012

Human milk oligosaccharides may reduce risk of mother-to-child HIV transmission

An international team of researchers has found that certain bioactive components found in human milk are associated with a reduced risk of HIV transmission from an HIV infected mother to her breast-fed infant. Their study will be published in the August 15 online edition of American Journal of Clinical Nutrition.

16 Aug 2012

Passenger deletions that deactivate essential genes provide new opportunity to strike cancer

Genomic deletions promote cancer by carving up or eliminating tumor-suppressor genes, but now scientists report in the journal Nature that the collateral damage they inflict on neighboring genes exposes cancer cells to vulnerabilities and new avenues for attack.

16 Aug 2012

Scientists researching Ebola virus say vaccine 'unlikely' due to funding restraints

"Scientists researching the lethal Ebola virus have told [BBC News] that a commercial vaccine to prevent the onset of infection may never be developed," the news service reports.

16 Aug 2012

APS’ Sharon S. Keller Chronic Pain Research Program to award $150,000 for eligible members

The American Pain Society (APS) announced today it is accepting applications for research grants from the newly established Sharon S. Keller Chronic Pain Research Program.

16 Aug 2012

Malignant mesothelioma diagnosis with an E-nose: an interview with Associate Professor Deborah Yates, UNSW

Malignant mesothelioma is a rare tumor of the pleura which is the lining of the inside of the chest wall. It is highly linked with asbestos exposure.

16 Aug 2012

RNA-delivering nanoparticles allow rapid screening of new drug targets in mice

By sequencing cancer-cell genomes, scientists have discovered vast numbers of genes that are mutated, deleted or copied in cancer cells. This treasure trove is a boon for researchers seeking new drug targets, but it is nearly impossible to test them all in a timely fashion.

16 Aug 2012

Researchers discover why people with sickle cell disease get milder cases of malaria

Researchers at Duke University Medical Center may finally have discovered why people with sickle cell disease get milder cases of malaria than individuals who have normal red blood cells.

16 Aug 2012

Cedars-Sinai's ICT-107 doubles median survival of patients with malignant brain tumor

An experimental immune-based therapy more than doubled median survival of patients diagnosed with the most aggressive malignant brain tumor, Cedars-Sinai Medical Center researchers reported in Cancer Immunology, Immunotherapy, published online Aug. 3.

16 Aug 2012

CYCLOPS genes may serve as targets for cancer therapies

The genomic tumult within tumor cells has provided scientists at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard with clues to an entirely new class of genes that may serve as an Achilles' heel for many forms of cancer.

16 Aug 2012

Combination of exercise and S-nitrosoglutathione improves recovery from stroke

In a study published in the current issue of Restorative Neurology and Neuroscience scientists report that a therapy combining exercise with the neurovascular protective agent S-nitrosoglutathione (GSNO) improved recovery from stroke in a rat model. GSNO is a compound found naturally in the body and it has no known side effects or toxicity.

16 Aug 2012

UCLA performs first transcatheter aortic valve replacement using new device

UCLA has performed its first transcatheter aortic valve replacement (TAVR), using a new device approved by the U.S. Food and Drug Administration to replace an aortic valve in a patient who was not a candidate for open-heart surgery. The procedure took place August 9th.

16 Aug 2012

Genocea commences GEN-003 Phase 1/2a study in moderate-to-severe HSV-2 infection

Genocea Biosciences announced today that it has initiated a Phase 1/2a clinical study with its lead candidate, GEN-003. GEN-003 is an investigational vaccine designed to stimulate T cell and B cell immune responses to potentially reduce the frequency and severity of clinical outbreaks associated with moderate-to-severe Herpes Simplex Virus type 2 (HSV-2) infection.

16 Aug 2012

Technion researchers build pancreatic tissue with insulin-secreting cells to treat diabetes

Technion researchers have built pancreatic tissue with insulin-secreting cells, surrounded by a three-dimensional network of blood vessels. The engineered tissue could pave the way for improved tissue transplants to treat diabetes.

16 Aug 2012

Cancer patients with xerostomia can benefit from regenerative research

Biologists, surgical oncologists and regenerative medicine specialists from Rice University, the University of Delaware and the Christiana Care Health System in Wilmington, Del., have begun a four-year program aimed at using cells to grow whole salivary glands that can replace those destroyed by cancer radiation therapy.

16 Aug 2012

Therapy News and Research

Combination of Zelboraf and immunotherapy increases tumor responses and survival in MM

Human milk oligosaccharides may reduce risk of mother-to-child HIV transmission

Passenger deletions that deactivate essential genes provide new opportunity to strike cancer

Scientists researching Ebola virus say vaccine 'unlikely' due to funding restraints

APS’ Sharon S. Keller Chronic Pain Research Program to award $150,000 for eligible members

Malignant mesothelioma diagnosis with an E-nose: an interview with Associate Professor Deborah Yates, UNSW

RNA-delivering nanoparticles allow rapid screening of new drug targets in mice

Researchers discover why people with sickle cell disease get milder cases of malaria

Cedars-Sinai's ICT-107 doubles median survival of patients with malignant brain tumor

CYCLOPS genes may serve as targets for cancer therapies

Combination of exercise and S-nitrosoglutathione improves recovery from stroke

UCLA performs first transcatheter aortic valve replacement using new device

Genocea commences GEN-003 Phase 1/2a study in moderate-to-severe HSV-2 infection

Technion researchers build pancreatic tissue with insulin-secreting cells to treat diabetes

Cancer patients with xerostomia can benefit from regenerative research

Low HDL cholesterol ADVANCEs nephropathy risk in diabetes

Nurse-led HIV care benefits patients

Mechanism for chemotherapy resistance identified

Pediatric imatinib for Philadelphia-chromosome ALL fights relapse

Short-term intervention alters neural architecture of stutterers

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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