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Acupuncture may offer limited relief from chronic spontaneous urticaria, study finds

A randomized controlled trial that included more than 300 people diagnosed with chronic spontaneous urticaria (CSU), or hives, found that acupuncture may offer limited relief from the condition, but clinical significance of this finding was unclear.

13 Nov 2023

Rat study suggests hemodialysis plus ketogenic diet could enhance cancer treatment

The study in Scientific Reports investigates the potential of hemodialysis (HD) to sustain elevated blood ketone levels in rats on a ketogenic diet, exploring its use as an adjunct in cancer treatment. Results show that HD maintains ketone levels while reducing glucose and insulin, suggesting a possible enhancement in cancer treatment efficacy.

13 Nov 2023

Study reveals coadministered COVID-19 and flu vaccines effective, especially in seniors

The study in JAMA Network Open evaluates the effectiveness of simultaneously administering the Pfizer-BioNTech BNT162b2 BA.4/5 COVID-19 vaccine and seasonal influenza vaccines versus separate administration. Results suggest similar or slightly increased COVID-19 outcomes and lower influenza-related outcomes with coadministration, particularly in those aged 65 and above.

13 Nov 2023

Study reveals underuse of antiviral medications in young children with influenza

Despite national medical guidelines supporting the use of antiviral medications in young children diagnosed with influenza, a new study reports an underuse of the treatment.

13 Nov 2023

Unlocking the cure for hepatitis B virus: Challenges and opportunities

Hepatitis B virus (HBV) is a significant public health problem, with over 296 million people chronically infected worldwide.

13 Nov 2023

New drug zilebesiran effectively lowers blood pressure for six months, study finds

A single injection of the experimental medication zilebesiran was safe and effective in reducing systolic blood pressure in people with mild-to-moderate high blood pressure for up to six months, as detailed in the Phase 2 of the KARDIA study, reported as late-breaking science today at the American Heart Association's Scientific Sessions 2023.

13 Nov 2023

CRISPR-based gene-editing therapy could offer hope for people with inherited high LDL cholesterol

A single infusion of a CRISPR-based gene-editing therapy significantly reduced low-density lipoprotein cholesterol (LDL, the "bad cholesterol") in people who carry one gene for the inherited condition that results in very high LDL cholesterol levels and a high risk of heart attack at an early age, according to late-breaking science presented today at the American Heart Association's Scientific Sessions 2023.

13 Nov 2023

Exploring the use of psychedelics as novel treatments for psychiatric disorders

Psychedelic compounds such as psilocybin, a substance found in various mushroom species, are garnering more research support as novel treatments for psychiatric disorders, but questions remain concerning who they may help the most.

13 Nov 2023

Advances in understanding and detecting Alzheimer's disease

Researchers are making strides toward understanding and detecting Alzheimer's disease in its earliest stages, when interventions may be most effective at slowing the progress of the disease.

13 Nov 2023

Next-generation ovarian cancer therapy: Engineered Vδ2 T cells show promise in preclinical trials

A prospective path for allogeneic cellular immunotherapies.

13 Nov 2023

New hope for TB patients as UNITE4TB launches clinical trial program

Today, UNITE4TB, an international public-private partnership striving to fast-track the development of innovative Tuberculosis (TB) treatments, announced the start of its phase 2B/C clinical trial program with the first participant enrolled at its trial site in Cape Town, South Africa.

13 Nov 2023

AdvanCell reaches milestone as first prostate cancer patient dosed with 212Pb-ADVC001

AdvanCell, a radiopharmaceutical company developing a pipeline of Targeted Alpha Therapies for cancer patients, today announced the first patient was treated with 212Pb-ADVC001, a Targeted Alpha Therapy in development for the treatment of PSMA-positive metastatic Castration-Resistant Prostate Cancer (mCRPC).

13 Nov 2023

MHRA and partners celebrate 10th anniversary of the International Coalition of Medicines Regulatory Authorities

As a founding member and former chair of the International Coalition of Medicines Regulatory Authorities (ICMRA), the Medicines and Healthcare products Regulatory Agency (MHRA) is joining global partners in celebrating ten years of strategic leadership and cooperation.

13 Nov 2023

Open-science triumph: Crowdsourced initiative yields potent SARS-CoV-2 antivirals

In this study, researchers harnessed crowdsourcing and open science to develop new antivirals against SARS-CoV-2, focusing on its main protease, Mpro. Their approach led to the discovery of potent compounds, including one with high efficacy in cell lines and cross-reactivity against various COVID-19 variants, demonstrating the potential of collaborative and transparent drug discovery in tackling global health crises.

12 Nov 2023

Study suggests concomitant antidepressant and statin use could prevent treatment discontinuation

A recent study in the journal BMC Medicine evaluates the real-world impact of combining antidepressants with statins in UK adults, revealing lower discontinuation rates but similar efficacy compared to antidepressant-only treatment.

12 Nov 2023

Gene therapy's double-edged sword: Breakthrough treatments face manufacturing and efficacy

Research explores the advancements, challenges, and economic implications of gene therapy for various diseases, including inherited blood disorders, malignancies treated with CAR-T cells, and diseases targeted by in vivo AAV vectors. The review highlights the transformative potential of gene therapies while acknowledging the complexities in manufacturing, safety, efficacy, and long-term durability.

12 Nov 2023

Autologous stem cell transplant shows promise for young patients with severe juvenile systemic sclerosis

New research at ACR Convergence 2023, the American College of Rheumatology's (ACR) annual meeting, shows that patients with refractory juvenile systemic sclerosis improved significantly on nearly all measures for two years following autologous stem cell transplant.

10 Nov 2023

Clinical trial underway for novel human milk-based microbiome therapy

In a breakthrough for human milk science, researchers at City of Hope, Los Angeles, have dosed the first patient in a Phase 2a clinical trial evaluating a novel therapy for blood cancer patients undergoing allogeneic hematopoietic stem cell transplantation.

10 Nov 2023

Data, Design, and Discovery: Andrew Buchanan's Impact on Biologics Innovation

Andrew Buchanan on the Future of Biologics and AI

10 Nov 2023

Mucosal vaccine shows lasting defense against SARS-CoV-2 Omicron in primate study

In this groundbreaking study, researchers developed a mucosal adenoviral-vector vaccine, ChAd-SARS-CoV-2-S, which demonstrated sustained and robust immunity against a challenging Omicron variant in nonhuman primates, indicating a promising direction for durable COVID-19 protection strategies. Unlike traditional intramuscular vaccines, this mucosal vaccine elicited a comprehensive immune response, potentially paving the way for more effective and long-lasting COVID-19 vaccines.

9 Nov 2023

Efficacy News and Research

Acupuncture may offer limited relief from chronic spontaneous urticaria, study finds

Rat study suggests hemodialysis plus ketogenic diet could enhance cancer treatment

Study reveals coadministered COVID-19 and flu vaccines effective, especially in seniors

Study reveals underuse of antiviral medications in young children with influenza

Unlocking the cure for hepatitis B virus: Challenges and opportunities

New drug zilebesiran effectively lowers blood pressure for six months, study finds

CRISPR-based gene-editing therapy could offer hope for people with inherited high LDL cholesterol

Exploring the use of psychedelics as novel treatments for psychiatric disorders

Advances in understanding and detecting Alzheimer's disease

Next-generation ovarian cancer therapy: Engineered Vδ2 T cells show promise in preclinical trials

New hope for TB patients as UNITE4TB launches clinical trial program

AdvanCell reaches milestone as first prostate cancer patient dosed with 212Pb-ADVC001

MHRA and partners celebrate 10th anniversary of the International Coalition of Medicines Regulatory Authorities

Open-science triumph: Crowdsourced initiative yields potent SARS-CoV-2 antivirals

Study suggests concomitant antidepressant and statin use could prevent treatment discontinuation

Gene therapy's double-edged sword: Breakthrough treatments face manufacturing and efficacy

Autologous stem cell transplant shows promise for young patients with severe juvenile systemic sclerosis

Clinical trial underway for novel human milk-based microbiome therapy

Data, Design, and Discovery: Andrew Buchanan's Impact on Biologics Innovation

Mucosal vaccine shows lasting defense against SARS-CoV-2 Omicron in primate study

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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