Mutation News and Research

RSS

Study shows faster uptake of chemicals in people with a genetically weakened skin barrier

The ability of our skin to protect us from chemicals is something we inherit. Some people are less well-protected which could imply an increased risk of being afflicted by skin disease or cancer.

13 Jan 2021

New UK-derived SARS-CoV-2 variant does not affect neutralizing antibodies efficiency, study says

A team of scientists conducted structural analysis of a newly emerged UK variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). They present evidence that suggests that while the new variant has increased infectivity it is not resistant to neutralizing antibodies.

13 Jan 2021

Large study provides new understanding of genome diversity in Ukrainian population

Today, the largest study of genetic diversity in Ukraine was published in the open science journal GigaScience.

13 Jan 2021

New results help understand biological phenomena mediated by cell membrane integrin receptors

Researchers at Tampere University, Finland, have published new results in collaboration with an international research network that help to understand the biological phenomena mediated by cell membrane integrin receptors and contribute to the development of methods for the treatment of cancer.

13 Jan 2021

Biologists reveal unusual structure of coronavirus protein linked to immune evasion

A team of HIV researchers, cellular biologists, and biophysicists who banded together to support COVID-19 science determined the atomic structure of a coronavirus protein thought to help the pathogen evade and dampen response from human immune cells.

13 Jan 2021

Intranasal vaccination effectively reduces viral shedding of SARS-CoV-2 in monkeys

A new preprint that appeared on the bioRxiv server reports that intranasal vaccination with the D614G variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus monkeys reduces viral shedding. This is an experiment in non-human primates (NHP), and its extrapolation to humans is unclear as yet.

12 Jan 2021

Effect of mutations in the South African SARS-CoV-2 variant on transmission and neutralization

One such strain is the South African 501.V2 and UK B1.1.7 strains, which have been isolated from many countries and seem to spread faster than the ancestral strain. A preprint that recently appeared on the bioRxiv server reports the computational structure of this strain and the possible effect of the mutations on infectivity and neutralization.

12 Jan 2021

Will the Pfizer–BioNTech vaccine be effective against the new N501Y SARS-CoV-2 variant?

Researchers from Pfizer and the University of Texas, USA, have presented evidence showing that people in a previously reported trial of the mRNA-based COVID-19 vaccine, BNT162b2 – commonly known as the Pfizer-BioNTech COVID-19 vaccine – had equivalent neutralizing titers to the N501 and Y501 viruses.

12 Jan 2021

Researchers determine the atomic structure of protein that helps coronavirus to evade immune cells

12 Jan 2021

Mosaic mutations during embryonic development can cause autism spectrum disorder

Two studies in today's Nature Neuroscience, led by researchers at Boston Children's Hospital, Brigham and Women's Hospital (BWH), and Harvard Medical School (HMS), implicate mosaic mutations arising during embryonic development as a cause of autism spectrum disorder (ASD). The findings open new areas for exploring the genetics of ASD and could eventually inform diagnostic testing.

11 Jan 2021

Study supports continuing phase 3 trials of Ad26.COV2.S SARS-CoV-2 vaccine

An international team of researchers has provided further evidence to confirm the immunogenicity and efficacy of a recombinant adenovirus vaccine currently being tested in phase 3 trials for its ability to protect against infection with severe acute respiratory coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

11 Jan 2021

Antibody recognition of linear SARS-CoV-2 epitopes preserved in mutated B.1.1.7 strain

In a recent medRxiv research paper, the US scientists examined the effects of non-synonymous mutations in the circulating B.1.1.7 strain of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on linear antibody epitope signal for viral spike glycoprotein and nucleoprotein – and demonstrated that mutations should not result in immune evasion.

11 Jan 2021

Master Regulator proteins control cancer transcriptional identity

Thousands of different genetic mutations have been implicated in cancer, but a new analysis of almost 10,000 patients found that regardless of the cancer's origin, tumors could be stratified in only 112 subtypes and that, within each subtype, the Master Regulator proteins that control the cancer's transcriptional state were virtually identical, independent of the specific genetic mutations of each patient.

11 Jan 2021

Study: 20% of glioblastomas are fueled by overactive mitochondria

A new study has found that up to 20% of glioblastomas--an aggressive brain cancer--are fueled by overactive mitochondria and may be treatable with drugs currently in clinical trials.

11 Jan 2021

Research opens up hope-filled possibilities for new autism therapies

Recent years have provided substantial research displaying the effect of genetic mutations on the development of autism and other neurodevelopmental disorders.

11 Jan 2021

Large-scale genome sequencing shows how SARS-CoV-2 mutated

A new study published on the preprint server bioRxiv* describes the results of genomic sequencing of the virus, which may help trace the routes of transmission of the virus from person to person, and from country to country.

10 Jan 2021

Study shows P681H mutation is becoming globally prevalent among SARS-CoV-2 sequences

In a recent bioRxiv preprint study, researchers from the University of Hawaii showed that the S gene of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously mutating according to the sequence and phylogenetic analysis.

10 Jan 2021

Naturally selected mutations of SARS-CoV-2 easily duplicated in vitro

In a recent and timely paper, currently available on the bioRxiv preprint server, researchers from Israel and France demonstrated how in vitro evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain (RBD) follows contagious mutation spread – but can also generate an efficient infection inhibitor.

10 Jan 2021

FDA alerts health care providers and clinical laboratory staff about SARS-CoV-2 viral mutation

The U.S. Food and Drug Administration is alerting clinical laboratory staff and health care providers that the FDA is monitoring the potential impact of viral mutations, including an emerging variant from the United Kingdom known as the B.1.1.7 variant, on authorized SARS-CoV-2 molecular tests, and that false negative results can occur with any molecular test for the detection of SARS-CoV-2 if a mutation occurs in the part of the virus's genome assessed by that test.

8 Jan 2021

High-affinity SARS-CoV-2 RBD drives mutation spread, forms basis of new COVID-19 inhibitor

Now, an intriguing recent study appeared on the bioRxiv * preprint server describes the use of in vitro evolution to elicit affinity maturation of the viral receptor-binding domain (RBD) of the spike protein to bind the host cell angiotensin-converting enzyme 2 (ACE2) with greater affinity.

7 Jan 2021

Mutation News and Research

Study shows faster uptake of chemicals in people with a genetically weakened skin barrier

New UK-derived SARS-CoV-2 variant does not affect neutralizing antibodies efficiency, study says

Large study provides new understanding of genome diversity in Ukrainian population

New results help understand biological phenomena mediated by cell membrane integrin receptors

Biologists reveal unusual structure of coronavirus protein linked to immune evasion

Intranasal vaccination effectively reduces viral shedding of SARS-CoV-2 in monkeys

Effect of mutations in the South African SARS-CoV-2 variant on transmission and neutralization

Will the Pfizer–BioNTech vaccine be effective against the new N501Y SARS-CoV-2 variant?

Researchers determine the atomic structure of protein that helps coronavirus to evade immune cells

Mosaic mutations during embryonic development can cause autism spectrum disorder

Study supports continuing phase 3 trials of Ad26.COV2.S SARS-CoV-2 vaccine

Antibody recognition of linear SARS-CoV-2 epitopes preserved in mutated B.1.1.7 strain

Master Regulator proteins control cancer transcriptional identity

Study: 20% of glioblastomas are fueled by overactive mitochondria

Research opens up hope-filled possibilities for new autism therapies

Large-scale genome sequencing shows how SARS-CoV-2 mutated

Study shows P681H mutation is becoming globally prevalent among SARS-CoV-2 sequences

Naturally selected mutations of SARS-CoV-2 easily duplicated in vitro

FDA alerts health care providers and clinical laboratory staff about SARS-CoV-2 viral mutation

High-affinity SARS-CoV-2 RBD drives mutation spread, forms basis of new COVID-19 inhibitor

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

Latest News