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Early exposure to inflammatory cytokines can paralyze CD4 T cells

In a discovery that is likely to rewrite immunology text books, researchers at UC Davis have found that early exposure to inflammatory cytokines, such as interleukin 2, can "paralyze" CD4 T cells, immune components that help orchestrate the body's response to pathogens and other invaders.

19 Aug 2015

Johns Hopkins scientists develop novel fish embryo technique to identify potential new treatments for diabetes

In experiments with 500,000 genetically engineered zebrafish embryos, Johns Hopkins scientists report they have developed a potentially better and more accurate way to screen for useful drugs, and they have used it to identify 24 drug candidates that increase the number of insulin-producing cells in the pancreas.

19 Aug 2015

Omeros reports additional positive data from OMS721 Phase 2 trial for treatment of thrombotic microangiopathies

Omeros Corporation today announced additional positive data in the company's Phase 2 clinical trial of OMS721 for the treatment of thrombotic microangiopathies (TMAs). TMAs are a family of rare, debilitating and life-threatening disorders characterized by excessive thrombi (clots) – aggregations of platelets – in the microcirculation of the body's organs, most commonly the kidney and brain.

18 Aug 2015

U-M microbiome research may lead to new ways to prevent, fight lung infections in patients

With every breath you take, microbes have a chance of making it into your lungs. But what happens when they get there? And why do dangerous lung infections like pneumonia happen in some people, but not others? Researchers at the University of Michigan Medical School have started to answer these questions by studying the microbiome of the lungs - the community of microscopic organisms that are in constant contact with our respiratory system.

18 Aug 2015

HCT not precluded by prior second-generation TKI therapy in chronic, advanced phase CML

Allogeneic haematopoietic stem cell transplantation can be considered for chronic- and accelerated-phase chronic myeloid leukaemia patients with prior exposure to second-generation tyrosine kinase inhibitors, say Polish researchers.

17 Aug 2015

Envarsus XR granted FDA orphan drug designation for prophylaxis of organ rejection in kidney transplant patients

Veloxis Pharmaceuticals A/S, today announced that Envarsus XR was granted Orphan Drug status by the U.S. Food and Drug Administration for prophylaxis of organ rejection in patients who convert from immediate-release tacrolimus. Envarsus XR received marketing authorization from the FDA on July 10, 2015.

14 Aug 2015

HCT not precluded by prior second-generation TKI therapy in chronic, advanced phase CML

14 Aug 2015

Organ transplant recipients more likely to develop melanoma

Organ transplant recipients are twice as likely to develop melanoma as people who do not undergo a transplant, and three times more likely to die of the dangerous skin cancer, suggests new research led by a Johns Hopkins Bloomberg School of Public Health student.

14 Aug 2015

USC kidney researcher named recipient of ASN-AHA Young Investigator Award

Keck School of Medicine of the University of Southern California kidney researcher Janos Peti-Peterdi is the 2015 recipient of the ASN-AHA Young Investigator Award.

14 Aug 2015

New research could help develop precision medicine for primary aldosteronism

Each of your kidneys wears a little yellow cap that helps keep your blood pressure in check, and much more. But in some people, it starts running amok, pumping out a hormone that sends blood pressure sky-high.

13 Aug 2015

Common marker can help identify patients at high risk for deadly cardiac events

A marker commonly used to determine if a patient is having a heart attack can also be used to identify stable patients at high risk for deadly cardiac events, according to a new study led by investigators at Brigham and Women's Hospital.

13 Aug 2015

JAYAO article highlights benefits and risks of adolescent sibling stem cell donation

A sibling may often be the best match for a patient who needs a stem cell transplant, but especially for adolescent donors, who are at a vulnerable age, factors such as the responsibility to donate versus a perception of free choice and the potential for anxiety and guilt in the face of complications or poor outcomes demand careful consideration.

12 Aug 2015

Only 1 in 4 patients with ESRD in Georgia referred for kidney transplant evaluation

Only about one in four patients with end-stage renal disease in Georgia were referred for kidney transplant evaluation within 1 year of starting dialysis between 2005 and 2011, although there was substantial variability in referral among dialysis facilities, according to a study in the August 11 issue of JAMA.

12 Aug 2015

TEAAM trial finds that testosterone has no effect on atherosclerosis progression

Testosterone sales have grown rapidly over the last decade, but few studies have examined the long-term effects of taking testosterone on cardiovascular health and other important outcomes. This week, investigators from Brigham and Women's Hospital report the results of the Testosterone's Effects on Atherosclerosis Progression in Aging Men (TEAAM) trial in the Journal of the American Medical Association.

12 Aug 2015

Breath analysis shows potential biomarkers for early-stage diagnosis of liver disease

A natural compound called limonene, which is found in oranges and lemons, could be indicative in early-stage diagnosis of liver disease, according to research published in the journal EBioMedicine by researchers in the Molecular Physics Group at the University of Birmingham.

12 Aug 2015

Investigational topical drug shows promise in patients with early stage cutaneous T cell lymphoma

Results of a phase one trial show that an investigational topical drug, resiquimod gel, causes regression of both treated and untreated tumor lesions and may completely remove cancerous cells from both sites in patients with early stage cutaneous T cell lymphoma (CTCL) - a rare type of non-Hodgkin lymphoma that affects the skin.

7 Aug 2015

Meniscal transplant surgery reduces pain, improves knee function in most patients younger than age 50

Most patients younger than age 50 with a torn or severely damaged meniscus experienced reduced pain and improved knee function following transplant surgery, according to a study in the August 5 issue of the Journal of Bone and Joint Surgery. However, many patients required additional surgery within 10 years.

6 Aug 2015

FamilyCord announces recent acquisition of LifeLine Cryogenics

California Cryobank Stem Cell Services LLC (dba "FamilyCord"), announced the recent acquisition of LifeLine Cryogenics, an east coast cord blood and reproductive tissue bank primarily servicing the New York tristate area. LifeLine clients will maintain full access to their invaluable tissues, and all prepaid contracts will be honored.

4 Aug 2015

UVA Stem Cell Transplant Program receives FACT accreditation for autologous and allogeneic transplants

The Stem Cell Transplant Program at the University of Virginia Cancer Center has received international accreditation for its use of stem cells and bone marrow to treat patients with blood cancers.

3 Aug 2015

Array Biopharma reports strong fourth quarter and full year 2015 financial results

Array BioPharma Inc. today reported results for the fourth quarter and full year of its fiscal year ended June 30, 2015.

3 Aug 2015

Transplant News and Research

Early exposure to inflammatory cytokines can paralyze CD4 T cells

Johns Hopkins scientists develop novel fish embryo technique to identify potential new treatments for diabetes

Omeros reports additional positive data from OMS721 Phase 2 trial for treatment of thrombotic microangiopathies

U-M microbiome research may lead to new ways to prevent, fight lung infections in patients

HCT not precluded by prior second-generation TKI therapy in chronic, advanced phase CML

Envarsus XR granted FDA orphan drug designation for prophylaxis of organ rejection in kidney transplant patients

HCT not precluded by prior second-generation TKI therapy in chronic, advanced phase CML

Organ transplant recipients more likely to develop melanoma

USC kidney researcher named recipient of ASN-AHA Young Investigator Award

New research could help develop precision medicine for primary aldosteronism

Common marker can help identify patients at high risk for deadly cardiac events

JAYAO article highlights benefits and risks of adolescent sibling stem cell donation

Only 1 in 4 patients with ESRD in Georgia referred for kidney transplant evaluation

TEAAM trial finds that testosterone has no effect on atherosclerosis progression

Breath analysis shows potential biomarkers for early-stage diagnosis of liver disease

Investigational topical drug shows promise in patients with early stage cutaneous T cell lymphoma

Meniscal transplant surgery reduces pain, improves knee function in most patients younger than age 50

FamilyCord announces recent acquisition of LifeLine Cryogenics

UVA Stem Cell Transplant Program receives FACT accreditation for autologous and allogeneic transplants

Array Biopharma reports strong fourth quarter and full year 2015 financial results

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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