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Linagliptin safe and effective for long-term management of type 2 diabetes

An extended trial of a drug for people with type 2 diabetes has confirmed that the oral DPP-4 inhibitor linagliptin is a safe and effective means of lowering glucose levels for up to 102 weeks, either on its own or in combination with other selected oral anti-diabetic medication.

23 Jul 2012

Egg allergy treatment for children: an interview with Dr Robert Wood

The tendency to get allergies is a fairly general one, which is mostly inherited – it tends to run in families. There are several foods that are most common for children to become allergic to: milk, egg and peanuts in most countries are the most common food allergies.

23 Jul 2012

HIV drug resistance rates rising in some parts of Africa

New research published Online First in The Lancet suggests that drug-resistant HIV has been increasing in parts of Sub-Saharan Africa since the roll-out of antiretroviral therapy (ART) nearly a decade ago.

23 Jul 2012

Study: Fewer Americans control their HIV infections

Tens of thousands of Americans taking potent antiretroviral therapies, or ART, to keep their HIV disease in check may not have as much control over the viral infection as previous estimates have suggested, according to results of a study by AIDS experts at Johns Hopkins and the University of Pennsylvania.

23 Jul 2012

Implementing multifaceted global effort may help end global HIV/AIDS pandemic

Ending the global HIV/AIDS pandemic may be possible by implementing a multifaceted global effort that expands testing, treatment, and prevention programs, as well as meets the scientific challenges of developing an HIV vaccine and possibly a cure, according to a Viewpoint in the July 25 issue of JAMA, a theme issue on HIV/AIDS.

23 Jul 2012

All adult patients with HIV should be offered ART: International Antiviral Society-USA panel

Included in the 2012 International Antiviral Society-USA panel recommendations for human immunodeficiency virus (HIV) patient care is that all adult patients, regardless of CD4 cell count, should be offered antiretroviral therapy (ART), according to an article in the July 25 issue of JAMA, a theme issue on HIV/AIDS.

23 Jul 2012

Study addresses African patients’ attitudes toward HIV antiretroviral therapy

An ongoing clinical study in rural Uganda, begun in 2011, suggests that many people infected with HIV/AIDS would take antiretroviral drugs if they were available to them—even before they developed symptoms from the disease.

23 Jul 2012

Targeting monocyte activation may reduce arterial inflammation in HIV-infected patients

The elevated risk of cardiovascular disease seen in patients infected with HIV appears to be associated with increased inflammation within the arteries, according to a study that will appear in a special issue of JAMA published in conjunction with the International AIDS Conference.

23 Jul 2012

Researchers link specific gene mutations with four recognized subtypes of medulloblastoma

Researchers at Dana-Farber/Children's Hospital Cancer Center (DF/CHCC) and several collaborating institutions have linked mutations in specific genes to each of the four recognized subtypes of medulloblastoma, the most common malignant brain tumor of children. The discovery, reported July in the journal Nature, provides doctors with potential biomarkers for guiding and individualizing treatment and reveals prospective therapeutic opportunities for countering this devastating malignancy.

23 Jul 2012

BioDiem presents positive findings of their eye disease drug at international conference

Australian infectious disease therapy and vaccine development company BioDiem Ltd (ASX: BDM) today announced positive results from formal studies of its BDM-E eye disease drug, presented over 21 – 22 July at the International Society for Eye Research (ISER) meeting in Berlin, Germany. The ISER convenes leading researchers and clinicians in the area of eye disease.

22 Jul 2012

Limit children's media exposure to the Colorado shooting tragedy

In the wake of the tragic shooting at the screening of The Dark Knight Rises in Aurora, Colo., parents should encourage their children to express their feelings and limit their media exposure to the tragedy, say experts from Children's Hospital Los Angeles.

21 Jul 2012

Anxiety in poor mothers not a psychiatric problem but a reaction to severe environmental deficits

Poor mothers are more likely to be classified as having the mental illness known as generalized anxiety disorder (GAD) because they live in poverty - not because they are suffering from a psychiatric disorder, according to Rutgers researchers.

21 Jul 2012

WHO identifies key actions countries can take to prevent HIV infections among people who inject drugs

WHO has identified four key actions countries can take to prevent viral hepatitis B and C among people who inject drugs. Of the estimated 16 million people who inject drugs worldwide, it is estimated that 10 million are infected with hepatitis C. An additional 1.2 million are infected with hepatitis B.

21 Jul 2012

IAS releases 'road map' to find HIV cure ahead of AIDS 2012 Conference

The International AIDS Society (IAS) on Thursday in Washington, D.C., "released what they call a road map for research toward a cure for HIV -- a strategy for global teams of scientists to explore a number of intriguing leads that just might, years from now, pan out," the Associated Press reports (Neergaard, 7/20).

21 Jul 2012

Kyprolis for multiple myeloma receives FDA approval under accelerated approval program

The U.S. Food and Drug Administration today approved Kyprolis (carfilzomib) to treat patients with multiple myeloma who have received at least two prior therapies, including treatment with Velcade (bortezomib) and an immunomodulatory therapy. A form of blood cancer that arises from plasma cells, multiple myeloma usually grows in bone marrow, the soft, spongy tissue found inside most bones.

21 Jul 2012

New CHAIT initiative on development of novel immunological therapeutic interventions

The CHAIT initiative is a public-private partnership focusing on the development of novel immunological therapeutic interventions to achieve a 'functional HIV cure' with the ultimate goal of HIV eradication.

21 Jul 2012

FDA grants accelerated approval for Kyprolis to treat multiple myeloma

Ligand Pharmaceuticals Incorporated today announced that its licensee, Onyx Pharmaceuticals, received accelerated approval from the U.S. Food and Drug Administration (FDA) for Kyprolis (carfilzomib) for Injection, a proteasome inhibitor indicated for the treatment of patients with multiple myeloma who have received at least two prior therapies, including bortezomib and an immunomodulatory agent, and have demonstrated disease progression on or within 60 days of completion of the last therapy.

21 Jul 2012

Experts examine host recognition of Staphylococcus and E.coli bacteria

We are surrounded by bacteria, viruses, fungi and parasites. The fact that we nevertheless do not fall prey to infections is thanks to certain cellular sensor molecules such as toll-like receptors (TLR), which recognize the molecular structure of pathogens and intercede by ensuring an often completely unnoticeable elimination of the invaders. Their immune-activating abilities were only detected in 1998, a discovery which was awarded with the Nobel Prize

21 Jul 2012

CBT, pharmacologic interventions decrease depressive symptoms in cancer patients

Despite guidelines recommending screening for depression in cancer patients, it's been unclear whether interventions designed to treat this depression are effective. A study by the University of Colorado Cancer Center and other institutions, published in the Journal of the National Cancer Institute, changes that.

21 Jul 2012

Cipla, DNDi to develop ARV combination therapy for children with HIV/AIDS

On the eve of the XIX International AIDS Conference in Washington, DC, the Drugs for Neglected Diseases initiative (DNDi), a not-for-profit research and development (R&D) organization, announces a new collaboration with Indian drug manufacturer Cipla to develop and produce an improved first-line antiretroviral (ARV) combination therapy specifically adapted to meet the treatment needs of infants and toddlers living with HIV/AIDS.

21 Jul 2012

Therapy News and Research

Linagliptin safe and effective for long-term management of type 2 diabetes

Egg allergy treatment for children: an interview with Dr Robert Wood

HIV drug resistance rates rising in some parts of Africa

Study: Fewer Americans control their HIV infections

Implementing multifaceted global effort may help end global HIV/AIDS pandemic

All adult patients with HIV should be offered ART: International Antiviral Society-USA panel

Study addresses African patients’ attitudes toward HIV antiretroviral therapy

Targeting monocyte activation may reduce arterial inflammation in HIV-infected patients

Researchers link specific gene mutations with four recognized subtypes of medulloblastoma

BioDiem presents positive findings of their eye disease drug at international conference

Limit children's media exposure to the Colorado shooting tragedy

Anxiety in poor mothers not a psychiatric problem but a reaction to severe environmental deficits

WHO identifies key actions countries can take to prevent HIV infections among people who inject drugs

IAS releases 'road map' to find HIV cure ahead of AIDS 2012 Conference

Kyprolis for multiple myeloma receives FDA approval under accelerated approval program

New CHAIT initiative on development of novel immunological therapeutic interventions

FDA grants accelerated approval for Kyprolis to treat multiple myeloma

Experts examine host recognition of Staphylococcus and E.coli bacteria

CBT, pharmacologic interventions decrease depressive symptoms in cancer patients

Cipla, DNDi to develop ARV combination therapy for children with HIV/AIDS

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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