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RUFY1-RET fusion identified as mechanism of resistance to lorlatinib in lung cancer

A new case report was published in Volume 16 of Oncotarget on February 5, 2025, titled "Acquired RUFY1-RET rearrangement as a mechanism of resistance to lorlatinib in a patient with CD74-ROS1 rearranged non-small cell lung cancer: A case report."

6 Feb 2025

KAIST team discovers molecular switch to reverse cancer cells

Professor Kwang-Hyun Cho's research team has recently been highlighted for their work on developing an original technology for cancer reversal treatment that does not kill cancer cells but only changes their characteristics to reverse them to a state similar to normal cells.

6 Feb 2025

Jumbo phages' protective shield offers clues for fighting antibiotic resistance

Scientists are learning more about how an intriguing type of virus protects itself. Revealing its strategies could boost the fight against antibiotic resistance.

6 Feb 2025

Advancing living materials with precise control over mechanical properties

Rice University researchers have revealed novel sequence-structure-property relationships for customizing engineered living materials (ELMs), enabling more precise control over their structure and how they respond to deformation forces like stretching or compression.

6 Feb 2025

Autism risk genes linked to white matter changes at birth, shaping early brain development

Genetic variants linked to autism are associated with structural differences in neonatal white matter, particularly increased fiber-bundle cross-section in the left superior corona radiata, highlighting early neurodevelopmental influences.

5 Feb 2025

How olive oil bioactives regulate genes linked to insulin resistance

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity, inflammation, and beta-cell function, offering potential benefits for Type 2 Diabetes Mellitus prevention and management.

5 Feb 2025

Inhibiting S6K2 gene offers potential treatment for drug-resistant melanoma

The lab of The Wistar Institute's Jessie Villanueva, Ph.D., has identified a new strategy for attacking treatment-resistant melanoma: inhibiting the gene S6K2. .

5 Feb 2025

AI predicts effective treatment for rare disease using existing medications

After combing through 4,000 existing medications, an artificial intelligence tool helped uncover one that saved the life of a patient with idiopathic multicentric Castleman's disease (iMCD).

5 Feb 2025

Study suggests a possible link between trauma and endometriosis

The study is an international collaboration based on previous research that has suggested a possible connection between trauma and endometriosis.

5 Feb 2025

Study could pave the way for routine eyecare imaging as a disease screening tool

Researchers have conducted one of the largest eye studies in the world to reveal new insights into retinal thickness, highlighting its potential in the early detection of diseases like type 2 diabetes, dementia and multiple sclerosis.

5 Feb 2025

New Kids First datasets offer insights into genetics of childhood disorders

The new Kids First datasets advance our understanding of how genetics contribute to childhood cancers and congenital disorders, opening new doors for prevention and treatment.

5 Feb 2025

Neurostimulation improves movement in adults with spinal muscle atrophy

A new drug-free, minimally invasive intervention targets the root cause of progressive loss of neural function in spinal muscle atrophy (SMA), an inherited neuromuscular disease.

5 Feb 2025

Breast cancer risk and chemical exposure: New evidence points to triclosan as a key culprit

Researchers found that moderate triclosan exposure is significantly linked to increased breast cancer risk, particularly in younger, overweight, and White women, while other endocrine-disrupting chemicals showed mixed or no associations.

4 Feb 2025

High HDL cholesterol may increase glaucoma risk in older adults

'Good' (HDL) cholesterol, usually considered to be beneficial for health, may be linked to a heightened risk of the serious eye condition, glaucoma-at least among the over 55s- suggest the results of a large observational study, published online in the British Journal of Ophthalmology.

4 Feb 2025

Researchers discover how RNA molecules influence multiple generations

RNA-based medicines are one of the most promising ways to fight human disease, as demonstrated by the recent successes of RNA vaccines and double-stranded RNA (dsRNA) therapies.

4 Feb 2025

Research uncovers enzyme essential for maintaining heart health

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart – an important process for maintaining heart health.

4 Feb 2025

International trial aims to prevent Alzheimer’s in high-risk young adults

The first participants in an international clinical trial aimed at preventing Alzheimer's disease in young adults at high risk of the disease have been enrolled.

4 Feb 2025

New insights into PTSD's genetic architecture unveiled by Dr. Kerry Ressler

In a comprehensive Genomic Press Interview, Dr. Kerry Ressler, Chief Scientific Officer at McLean Hospital and Professor of Psychiatry at Harvard Medical School, unveils groundbreaking advances in understanding the neurobiological basis of post-traumatic stress disorder (PTSD) and related anxiety conditions.

4 Feb 2025

Maternal stress may leave epigenetic marks on certain placental genes

Maternal stress could leave epigenetic imprints on genes in the placenta associated with cortisol — a necessary hormone for fetal development — and this would affect the baby's development from very early stages, as stated in a paper published in the journal European Neuropsychopharmacology.

4 Feb 2025

New discovery offers hope for stopping childhood brain tumors before they start

Scientists at The Hospital for Sick Children (SickKids) have discovered a way to stop tumour growth before it starts for a subtype of medulloblastoma, the most common childhood malignant brain cancer.

4 Feb 2025