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First study to demonstrate long-term and sustained cardiac benefit for patients after gastric bypass

Total cholesterol, triglycerides and C-reactive protein levels are among 11 risk factors for heart attack that remained greatly reduced up to seven years after gastric bypass surgery, according to a new Stanford University study presented here at the 29th Annual Meeting of the American Society for Metabolic & Bariatric Surgery.

21 Jun 2012

Bariatric surgery can remit or prevent diabetic nephropathy in obese patients

In many obese diabetic patients, one of the most dreaded complications of Type 2 diabetes can be put into remission or prevented entirely with bariatric surgery, according to a new study from the Cleveland Clinic presented here at the 29th Annual Meeting of the American Society for Metabolic & Bariatric Surgery.

21 Jun 2012

Tinkering with p190RhoGAP molecule shapes development of cardiac stem cells

Johns Hopkins researchers have discovered that a single protein molecule may hold the key to turning cardiac stem cells into blood vessels or muscle tissue, a finding that may lead to better ways to treat heart attack patients.

21 Jun 2012

FDA grants Orphan Drug Designation to Medgenics’ INFRADURE Biopump

Medgenics, Inc., the developer of Biopump, a novel technology for the sustained production and delivery of therapeutic proteins in patients using their own tissue, today announced that its INFRADURE Biopump has received Orphan Drug Designation from the U.S. Food and Drug Administration (FDA) Office of Orphan Products Development (OOPD) for the treatment of hepatitis D.

21 Jun 2012

Researchers can silence mutated gene responsible for Huntington's with single drug treatment

With a single drug treatment, researchers at the Ludwig Institute for Cancer Research at the University of California, San Diego School of Medicine can silence the mutated gene responsible for Huntington's disease, slowing and partially reversing progression of the fatal neurodegenerative disorder in animal models.

21 Jun 2012

Review describes new classes of drugs that target androgens in novel ways

Prostate cancer cells require androgens including testosterone to grow. A recent review in the British Journal of Urology International describes new classes of drugs that target androgens in novel ways, providing alternatives to the traditional methods that frequently carry high side effects.

21 Jun 2012

FDA ODAC votes in favor of Onyx’s Kyprolis

Onyx Pharmaceuticals, Inc. today announced that the U.S. Food and Drug Administration's (FDA) Oncologic Drugs Advisory Committee (ODAC) determined by a vote of 11-0 with 1 abstention that, in patients with relapsed and refractory multiple myeloma who have received at least two prior lines of therapy that included a proteasome inhibitor and an immunomodulatory agent (IMiD), the benefit-risk assessment is favorable for the use of Kyprolis.

21 Jun 2012

Gold nanoparticles with slight positive charge work collectively to unravel DNA's double helix

New research from North Carolina State University finds that gold nanoparticles with a slight positive charge work collectively to unravel DNA's double helix. This finding has ramifications for gene therapy research and the emerging field of DNA-based electronics.

21 Jun 2012

Value of pathology review highlighted in node-negative breast cancer

Secondary pathology review results in significant changes in diagnosis and treatment for women with node-negative breast cancer, Canadian researchers report.

20 Jun 2012

Engaging in daily activities with children can reduce stress among single mothers

A group of three Kansas State University researchers is studying ways to help single mothers improve their relationship with their children.

20 Jun 2012

NewYork-Presbyterian/WCMC join new MDS Clinical Research Consortium

NewYork-Presbyterian/Weill Cornell Medical Center is one of six institutions selected to join the newly-founded MDS Clinical Research Consortium.

20 Jun 2012

HCHD to offer APTA-accredited post-professional physical therapy residency programs

The Harris County Hospital District joins only one other public healthcare system in the nation to offer two post-professional physical therapy residency programs with the recent accreditation of the Neurologic Physical Therapy Residency by the American Physical Therapy Association.

20 Jun 2012

Bariatric procedure increases risk of alcohol use disorders two years after surgery

Adults who had a common bariatric surgery to lose weight had a significantly higher risk of alcohol use disorders (AUD) two years after surgery, according to a study by a National Institutes of Health research consortium.

20 Jun 2012

Study identifies critical neurological factor in aggression

Pathological rage can be blocked in mice, researchers have found, suggesting potential new treatments for severe aggression, a widespread trait characterized by sudden violence, explosive outbursts and hostile overreactions to stress.

20 Jun 2012

Young men with HIV more likely to experience low bone mass

Young men being treated for HIV are more likely to experience low bone mass than are other men their age, according to results from a research network supported by the National Institutes of Health. The findings indicate that physicians who care for these patients should monitor them regularly for signs of bone thinning, which could foretell a risk for fractures. The young men in the study did not have HIV at birth and had been diagnosed with HIV an average of two years earlier.

20 Jun 2012

Combination therapy may help defeat pancreatic cancer

Combining a new targeted therapy with standard chemotherapy may help defeat pancreatic cancer, according to results presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held here June 18-21.

20 Jun 2012

Emergence of drug resistance to ARVs has potential to 'curb, and even reverse' gains against HIV

Noting that the "roll-out of antiretroviral treatment for HIV in sub-Saharan Africa has been accompanied by rising rates of drug resistance," Raph Hamers, a global health research fellow at the Academic Medical Centre of the University of Amsterdam, and colleagues "call for improved patient management and the integration of population-based drug resistance surveillance into national treatment programs" in this BMJ analysis.

20 Jun 2012

Inserm researchers examine effect of night work on women’s health

Breast cancer is the number one cause of female mortality. It affects 100 out of 100,000 women per year in developed countries. Each year, more than 1.3 million new cases are diagnosed, 53,000 of these in France. The risk factors of breast cancer are varied. They include genetic mutations, late first pregnancy, low parity or hormone therapy, but other causes of breast cancer such as way of life, environmental or professional causes have not yet been completely identified.

20 Jun 2012

KPT-SINEs might offer new treatment for people with acute leukemia

A novel family of experimental agents that blocks a molecule from shuttling proteins out of the cell nucleus might offer a new treatment for people with acute leukemia, according to a study by researchers at the Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

20 Jun 2012

FDA, EMA grant orphan drug designation to bluebird bio's gene therapy product for adrenoleukodystrophy

bluebird bio, a leader in the development of innovative gene therapies for severe genetic disorders, announced today that both the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have granted an orphan drug designation to its investigational gene therapy product for the treatment of adrenoleukodystrophy (ALD).

19 Jun 2012

Therapy News and Research

First study to demonstrate long-term and sustained cardiac benefit for patients after gastric bypass

Bariatric surgery can remit or prevent diabetic nephropathy in obese patients

Tinkering with p190RhoGAP molecule shapes development of cardiac stem cells

FDA grants Orphan Drug Designation to Medgenics’ INFRADURE Biopump

Researchers can silence mutated gene responsible for Huntington's with single drug treatment

Review describes new classes of drugs that target androgens in novel ways

FDA ODAC votes in favor of Onyx’s Kyprolis

Gold nanoparticles with slight positive charge work collectively to unravel DNA's double helix

Value of pathology review highlighted in node-negative breast cancer

Engaging in daily activities with children can reduce stress among single mothers

NewYork-Presbyterian/WCMC join new MDS Clinical Research Consortium

HCHD to offer APTA-accredited post-professional physical therapy residency programs

Bariatric procedure increases risk of alcohol use disorders two years after surgery

Study identifies critical neurological factor in aggression

Young men with HIV more likely to experience low bone mass

Combination therapy may help defeat pancreatic cancer

Emergence of drug resistance to ARVs has potential to 'curb, and even reverse' gains against HIV

Inserm researchers examine effect of night work on women’s health

KPT-SINEs might offer new treatment for people with acute leukemia

FDA, EMA grant orphan drug designation to bluebird bio's gene therapy product for adrenoleukodystrophy

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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