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Implanted cells deliver a biologic drug in response to inflammation in rheumatoid arthritis

With a goal of developing rheumatoid arthritis therapies with minimal side effects, researchers at Washington University School of Medicine in St. Louis have genetically engineered cells that, when implanted in mice, will deliver a biologic drug in response to inflammation.

1 Sep 2021

Study shows bacille Calmette-Guérin vaccine can protect mice against lethal SARS-CoV-2 challenge

A recent US study, currently available on bioRxiv* preprint server, implies that vaccination with bacille Calmette-Guérin (BCG) can limit the infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by targeting innate immune pathways and could thus be used as a platform for pinpointing early immunologic events affecting the outcome of coronavirus disease (COVID-19).

1 Sep 2021

Do kidney transplant recipients need a third booster dose of mRNA COVID-19 vaccine?

A team of researchers in France have observed that the “standard” 2 dose regimen for mRNA COVID-19 vaccines could provide adequate protection to only a few KTRs. It has also been shown in multiple studies that a considerable population of vaccinated KTRs were easily infected with SARS-CoV-2.

1 Sep 2021

Researchers explore the fate of dietary fructose in the body

In today's fast-paced world, the dependence on the widely available "fast" foods and beverages has risen. These foods are typically low in fiber and essential nutrients, and often consist of high amounts of added sugar. This shift in dietary trends, accompanied by a sedentary lifestyle, has been attributed to the rise in various metabolic disorders like diabetes, fatty liver disease, and heart disease.

31 Aug 2021

Severe COVID-19 negatively impacts kidney function in kidney transplant recipients

During her medical school career, third-year student Skylar Nahi has taken advantage of the mentorship and research opportunities available to Feinberg students.

31 Aug 2021

New, one-stop method developed to avoid de novo genetic disease in embryos

De novo variants (DNVs), genetic mutations that were not previously identifiable in the family history of one of two prospective parents, may cause disease in any children they have.

31 Aug 2021

Shorter survival of multiple myeloma subgroup linked to worse kidney damage

Nearly 20% of patients with multiple myeloma have a form in which they make extreme quantities of one component of the abnormal antibody they are producing, and these so-called "free monoclonal light chains" pile up and damage the kidneys, investigators say.

31 Aug 2021

Black patients who receive kidneys from Asian donors have higher risk of kidney graft failure

Black transplant recipients and patients who received kidneys from Asian donors had a significantly higher risk of kidney graft failure within seven years, according to a new study presented at the European Society for Organ Transplantation (ESOT) Congress 2021.

31 Aug 2021

Low-sodium alternative for salt lowers stroke risk

Replacing salt with a low-sodium alternative lowers the risk of stroke in people with high blood pressure or prior stroke, according to late breaking research presented in a Hot Line session today at ESC Congress 2021 and published in the New England Journal of Medicine.

30 Aug 2021

Gitelman syndrome more common in Japanese population than previously reported

Clinical Fellow KONDO Atsushi and Professor NOZU Kandai et al. of Kobe University's Graduate School of Medicine have estimated the prevalence of Gitelman syndrome across different ethnicities using a genome database.

30 Aug 2021

More than 80% of hypertension cases now found in poorer countries

More than half a billion people worldwide live with undetected, untreated hypertension, even as the disease burden shifts from rich nations to poor countries with limited resources to detect and manage the condition.

30 Aug 2021

UH associate professor receives $2.5 million to explore how arterial hardening starts within cells

In diseases such as hypertension, aging, atherosclerosis, diabetes and chronic kidney disease, arterial calcification and stiffening of the elastic layer of the arterial wall are almost always present.

30 Aug 2021

‘My time to live’: Through novel program, kidney patients get palliative care, dialysis ’til the end

After a decade of living with chronic kidney disease, Vonita McGee knows her body is wearing out.

30 Aug 2021

Study highlights the robustness of miRNA modulation during aging process

Aging-US published "miRNAs generated from Meg3-Mirg locus are downregulated during aging" which reported that Aging determines a multilevel functional decline and increases the risk for cardiovascular pathologies.

28 Aug 2021

'Humanized' mouse model beats current approaches for finding the best organ donor

A "humanized" mouse model equipped with the immune system of a patient who needs an organ transplant beats current measures for identifying the best potential living donor, scientists report.

27 Aug 2021

ACTG announces positive data for monoclonal antibody combination therapy from the ACTIV-2 study

The AIDS Clinical Trials Group, the largest global HIV research network, which has expanded its focus to include evaluating outpatient treatment for COVID-19, today announced positive data for the monoclonal antibody combination therapy BRII-196/BRII-198 from the ACTIV-2 study of Outpatient Monoclonal Antibodies and Other Therapies.

27 Aug 2021

New ESC guidelines for diagnosis and treatment of heart failure published

The European Society of Cardiology Guidelines for the diagnosis and treatment of acute and chronic heart failure are published online today in European Heart Journal.

27 Aug 2021

Study examines safety of COVID-19 vaccine in a nationwide mass-vaccination setting

The Clalit Research Institute, in collaboration with researchers from Harvard University, analyzed one of the world's largest integrated health record databases to examine the safety of the Pfizer/BioNTech BNT162B2 vaccine against COVID-19.

27 Aug 2021

Study: Smell regulates our eating habits

Walking past a corner bakery, you may find yourself drawn in by the fresh smell of sweets wafting from the front door. You're not alone: The knowledge that humans make decisions based on their noses has led major brands like Cinnabon and Panera Bread to pump the scents of baked goods into their restaurants, leading to big spikes in sales.

27 Aug 2021

New MOGONET outperforms existing supervised multi-omics integrative analysis approaches

Genomics, proteomics, metabolomics, transcriptomics -- rapid advances in high-throughput biomedical technologies has enabled the collection of data with unprecedented detail from the growing number of omics.

27 Aug 2021

Kidney News and Research

Implanted cells deliver a biologic drug in response to inflammation in rheumatoid arthritis

Study shows bacille Calmette-Guérin vaccine can protect mice against lethal SARS-CoV-2 challenge

Do kidney transplant recipients need a third booster dose of mRNA COVID-19 vaccine?

Researchers explore the fate of dietary fructose in the body

Severe COVID-19 negatively impacts kidney function in kidney transplant recipients

New, one-stop method developed to avoid de novo genetic disease in embryos

Shorter survival of multiple myeloma subgroup linked to worse kidney damage

Black patients who receive kidneys from Asian donors have higher risk of kidney graft failure

Low-sodium alternative for salt lowers stroke risk

Gitelman syndrome more common in Japanese population than previously reported

More than 80% of hypertension cases now found in poorer countries

UH associate professor receives $2.5 million to explore how arterial hardening starts within cells

‘My time to live’: Through novel program, kidney patients get palliative care, dialysis ’til the end

Study highlights the robustness of miRNA modulation during aging process

'Humanized' mouse model beats current approaches for finding the best organ donor

ACTG announces positive data for monoclonal antibody combination therapy from the ACTIV-2 study

New ESC guidelines for diagnosis and treatment of heart failure published

Study examines safety of COVID-19 vaccine in a nationwide mass-vaccination setting

Study: Smell regulates our eating habits

New MOGONET outperforms existing supervised multi-omics integrative analysis approaches

Event guide: 8th CKD Summit 2026 eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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