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HSS research highlights faster recovery methods after knee surgery

At this year's American Academy of Orthopedic Surgeons (AAOS) annual meeting, investigators at Hospital for Special Surgery (HSS) presented several significant studies, with three focused on new ways to help patients recover faster after total knee arthroplasty (TKA), also known as knee replacement surgery.

11 Mar 2025

Gender gaps in peripheral vascular disease impact diagnosis and treatment

The disparities between men and women in prevalence, risk factors and symptoms of peripheral vascular disease (PVD) have a profound impact on prevention, diagnosis, treatment and outcomes for women, according to a new American Heart Association scientific statement published today in the Association's flagship, peer-reviewed journal Circulation.

11 Mar 2025

Integrated anti-aging strategy could reduce neurodegeneration

Aging significantly impacts neurodegeneration, increasing risks for diseases like Alzheimer's. Research focuses on therapies to enhance cognitive function.

11 Mar 2025

Study reveals the role of transcription factors as therapeutic gateways in MAFLD

Metabolic dysfunction-associated fatty liver disease (MAFLD) has become a growing global health concern, affecting millions worldwide. This complex liver disorder ranges from simple steatosis to more severe forms, including metabolic dysfunction-associated steatohepatitis (MASH), which may progress to fibrosis, cirrhosis, and even liver cancer.

11 Mar 2025

Decoding programmed cell death in breast cancer

This review highlights the critical role of ubiquitin-specific proteases (USPs) in regulating programmed cell death (PCD) in breast cancer (BC). As the most prevalent malignant tumor among women, BC remains a significant global health challenge.

11 Mar 2025

Study highlights the role of ELF4 as a key transcription factor in development, immunity, and oncology

ELF4, a transcription factor belonging to the ETS family, has emerged as a pivotal regulator in cell differentiation, immune system function, and cancer progression. This newly published review underscores its molecular complexity and clinical significance, shedding light on its dual role in tumor suppression and oncogenesis.

11 Mar 2025

Study reveals TCM-Based strategies for ferroptosis modulation

Innovative insights into the role of ferroptosis, a unique form of programmed cell death, are reshaping the landscape of disease treatment. This growing field highlights how Traditional Chinese Medicine (TCM) can effectively modulate ferroptosis, offering novel therapeutic approaches for various conditions, including cancer, cardiovascular diseases, neurodegenerative disorders, and organ injuries.

11 Mar 2025

Ovarian cancer mutations across populations show similarities and unique differences

An extensive tumor genomic analysis of individuals with ovarian cancer, led by researchers from Huntsman Cancer Institute at the University of Utah (the U) and Emory University, revealed that Black women have nearly identical mutations to other previously studied populations.

10 Mar 2025

New test could predict life-threatening side effects of cancer immunotherapy

Medical researchers in Japan have discovered a way to predict a potentially life-threatening side effect of cancer immunotherapy before it occurs.

10 Mar 2025

Platelet-rich plasma may enhance ovarian rejuvenation and improve egg quality in women

A new research paper was published in Aging (Aging-US) on February 18, 2025, Volume 17, Issue 2, titled "Transcriptomic landscape of cumulus cells from patients <38 years old with a history of poor ovarian response (POR) treated with platelet-rich plasma (PRP)."

10 Mar 2025

Reproductive justice principles improve perinatal mental health for Black birthing patients

Perinatal interventions guided by reproductive justice principles can have positive effects on the perinatal mental health of Black birthing patients and, perhaps, the mental health development of their infants, states a systematic review published in a special issue of Harvard Review of Psychiatry, part of the Lippincott portfolio from Wolters Kluwer.

10 Mar 2025

Breakthrough drug combination targets KRAS mutation in lung cancer

A breakthrough in lung cancer treatment may be on the horizon. Scientists at VCU Massey Comprehensive Cancer Center have uncovered a powerful combination therapy leveraging sotorasib-an FDA-approved drug in the market-and an experimental drug called FGTI-2734, which could make precision medicine more effective for patients with a highly resistant form of lung cancer.

10 Mar 2025

New supercharged CAR-T cell therapy shows promise against resistant cancers

Researchers at the University of Colorado Anschutz Medical Campus have successfully developed a supercharged iteration of CAR-T cell therapy that can enhance the effectiveness and longevity of the cells, particularly against cancer cells that are harder for prior CAR-T therapies to detect and fight.

10 Mar 2025

Many individuals with Niemann-Pick disease lack neutralizing antibodies against AAV2 or AAV9

A new study in the peer-reviewed journal Human Gene Therapy showed that more than half of individuals with Niemann-Pick disease, type C1 (NPC1) who were tested lacked neutralizing antibodies against either adeno-associated virus (AAV) 2 or AAV9.

10 Mar 2025

Walking more steps and exercise linked to lower risk of death in postmenopausal cancer survivors

Among postmenopausal women with a history of cancer, taking more daily steps and engaging in moderate-to-vigorous physical activity were both associated with a significantly reduced risk of death from cardiovascular disease, according to preliminary research presented at the American Heart Association's Epidemiology and Prevention | Lifestyle and Cardiometabolic Health Scientific Sessions 2025.

10 Mar 2025

Restoring gut health in ulcerative colitis through microbiome-based therapy

The human gut is home to trillions of bacteria that play vital roles in digestion, immunity, and overall health.

10 Mar 2025

Reprogramming T cells to overcome tumor challenges

Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center for Cancer Biology and their collaborators demonstrated a remarkable ability to boost the immune system's fight against cancer, showing promise for improving patient outcomes in difficult-to-treat malignancies.

10 Mar 2025

New insights into dental problems in hypophosphatasia patients

Hypophosphatasia is a relatively common skeletal disease that primarily affects bone and tooth strength. In the third national dental survey of hypophosphatasia in Japan, recently published in Scientific Reports, researchers analyzed the dental issues faced by Japanese patients in their largest survey to date.

10 Mar 2025

Can microbiome discoveries finally become treatments? Scientists show the way

Researchers propose a novel iterative strategy combining big data and experimental models to move microbiome research from theory to clinical applications. The study highlights the need to bridge the gap between correlation and causation to develop effective microbiome-based therapies.

9 Mar 2025

Understanding the role of LSD1 in cellular processes and disease

A new review highlights the pivotal role of LSD1 (lysine-specific demethylase 1) in regulating critical cellular processes and its implications for human diseases.

8 Mar 2025

Therapy News and Research

HSS research highlights faster recovery methods after knee surgery

Gender gaps in peripheral vascular disease impact diagnosis and treatment

Integrated anti-aging strategy could reduce neurodegeneration

Study reveals the role of transcription factors as therapeutic gateways in MAFLD

Decoding programmed cell death in breast cancer

Study highlights the role of ELF4 as a key transcription factor in development, immunity, and oncology

Study reveals TCM-Based strategies for ferroptosis modulation

Ovarian cancer mutations across populations show similarities and unique differences

New test could predict life-threatening side effects of cancer immunotherapy

Platelet-rich plasma may enhance ovarian rejuvenation and improve egg quality in women

Reproductive justice principles improve perinatal mental health for Black birthing patients

Breakthrough drug combination targets KRAS mutation in lung cancer

New supercharged CAR-T cell therapy shows promise against resistant cancers

Many individuals with Niemann-Pick disease lack neutralizing antibodies against AAV2 or AAV9

Walking more steps and exercise linked to lower risk of death in postmenopausal cancer survivors

Restoring gut health in ulcerative colitis through microbiome-based therapy

Reprogramming T cells to overcome tumor challenges

New insights into dental problems in hypophosphatasia patients

Can microbiome discoveries finally become treatments? Scientists show the way

Understanding the role of LSD1 in cellular processes and disease

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