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Research illuminates regulatory mechanism of ubiquitin-proteasome system in DNA damage repair

An international research team has clarified the regulatory mechanism of the ubiquitin-proteasome system in recognizing and repairing DNA that has been damaged by ultraviolet (UV) light.

8 Dec 2020

Chemotherapy combined with blinatumomab increases survival for patients with Ph-negative B-ALL

A study led by The University of Texas MD Anderson Cancer Center showed that first-line treatment with a regimen of chemotherapy combined with the monoclonal antibody blinatumomab resulted in increased survival and achieved a high rate of measurable residual disease (MRD) negativity for patients who were newly diagnosed with a high-risk form of acute lymphoblastic leukemia (ALL) known as Philadelphia chromosome-negative B-cell ALL (Ph-negative B-ALL).

7 Dec 2020

RNA mutations within common bacterium linked to invasive meningococcal disease

Researchers at Karolinska Institutet in Sweden have come one step closer toward understanding why some people become seriously ill or die from a common bacterium that leaves most people unharmed.

7 Dec 2020

Paper-based electrochemical sensor can enable rapid detection of SARS-CoV-2

As the COVID-19 pandemic continues to spread across the world, testing remains a key strategy for tracking and containing the virus.

7 Dec 2020

D614/G614 variants of SARS-CoV-2 affect neuronal transmission; G614 better at membrane fusion

The COVID-19 pandemic is showing a strong comeback after an initial reduction in the number of cases, following energetic public health interventions.

7 Dec 2020

Clinical investigators present abstracts on hematological malignancies at ASH Annual Meeting and Exposition

Clinical investigators from Hackensack Meridian Health John Theurer Cancer Center (JTCC), a member of the Georgetown Lombardi Comprehensive Cancer Center consortium, are to present updates on treatment advances in multiple myeloma (MM), mantle cell lymphoma (MCL), and other types of B-cell lymphoma (BCL) as well as leukemia at the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, to be held virtually from December 5-8, 2020.

7 Dec 2020

Clonal hematopoiesis can confer a health benefit in allogeneic transplants

Clonal hematopoiesis (CH) is a recently identified condition in which mutations associated with blood cancers are detected in the blood of some healthy, usually older, individuals who don't have cancer.

7 Dec 2020

Study finds surprising link between ALS, FTD and Huntington's disease-associated mutation

A study led by researchers at the National Institutes of Health has made a surprising connection between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two disorders of the nervous system, and the genetic mutation normally understood to cause Huntington's disease.

5 Dec 2020

Researchers develop a promising fix to CRISPR-Cas9's unwanted changes problem

A group of researchers developed a promising fix to CRISPR-Cas9's problem with unwanted genetic changes using a method that allows them to turn off gene-editing until it reaches key cell cycle phases where more accurate repairs are likely to happen.

4 Dec 2020

ATCC introduces new product segment with launch of SARS-CoV-2 external control kit

ATCC today announced the introduction of its new SARS-CoV-2 External Control Kit for clinical laboratories and test manufacturers.

From American Type Culture Collection (ATCC) 4 Dec 2020

Study provides mechanistic insights about the role of neutrophils in psoriasis pathogenesis

Psoriasis has always been a common disease. Historically, its causes were obscure and surrounded by stigma; it wasn't until recently that scientists categorized it as an autoimmune condition.

4 Dec 2020

Long-range allosteric influences on SARS-COV-2-ACE2 stability and detachment

The COVID-19 pandemic is caused by SARS-CoV-2, a novel beta-coronavirus which has numerous spike proteins on its membrane.

3 Dec 2020

Guidelines for accurate amplicon-based sequencing of SARS-CoV-2

A new study describes much-needed guidelines for reliable viral sequencing, validated in a large group of clinical samples.

3 Dec 2020

COVID-19 mutation mapping identifies escape mutations against therapeutic antibodies

A new study maps all known mutations in the SARS-CoV-2 virus, showing how each contributes to escape from individual antibodies.

3 Dec 2020

Circadian gene mutation increases drug-taking behaviors in mice

A mutation in the gene regulating circadian rhythms increases self-administration of cocaine in mice, University of Pittsburgh Schools of the Health Sciences researchers found in a paper published today in the Journal of Neuroscience.

2 Dec 2020

Surprising discovery reveals new target for aggressive lung adenocarcinoma

Targeted therapies are currently available for about one-third of people with lung adenocarcinoma, the most common kind of lung cancer.

2 Dec 2020

SARS-CoV-2 D614G mutation does not affect performance of serological assays

In a new study published in The Journal of Infectious Diseases, US researchers considered the emergence of a new SARS-CoV-2 spike protein variant. They compared spike G614-based assay to the original D614-based assay – pointing towards the development of recognizable, cross-responsive humoral immunity.

2 Dec 2020

Mutation News and Research

Research illuminates regulatory mechanism of ubiquitin-proteasome system in DNA damage repair

Chemotherapy combined with blinatumomab increases survival for patients with Ph-negative B-ALL

RNA mutations within common bacterium linked to invasive meningococcal disease

Paper-based electrochemical sensor can enable rapid detection of SARS-CoV-2

D614/G614 variants of SARS-CoV-2 affect neuronal transmission; G614 better at membrane fusion

Clinical investigators present abstracts on hematological malignancies at ASH Annual Meeting and Exposition

Clonal hematopoiesis can confer a health benefit in allogeneic transplants

Study finds surprising link between ALS, FTD and Huntington's disease-associated mutation

Researchers develop a promising fix to CRISPR-Cas9's unwanted changes problem

ATCC introduces new product segment with launch of SARS-CoV-2 external control kit

Study provides mechanistic insights about the role of neutrophils in psoriasis pathogenesis

Long-range allosteric influences on SARS-COV-2-ACE2 stability and detachment

Guidelines for accurate amplicon-based sequencing of SARS-CoV-2

COVID-19 mutation mapping identifies escape mutations against therapeutic antibodies

Circadian gene mutation increases drug-taking behaviors in mice

Surprising discovery reveals new target for aggressive lung adenocarcinoma

SARS-CoV-2 D614G mutation does not affect performance of serological assays

Spanish-originated SARS-CoV-2 variant A222V shows rapid spread in Lazio, Italy

Study: Tumors with high TMB tend to respond better to immune checkpoint inhibitors

Novel method for creating chemical reactions could unlock many new applications

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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