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Understanding recombination rates in RNA viruses

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30 Aug 2022

Disrupting a virus’s genome packaging can halt replication, study finds

Like savvy international travelers, viruses know exactly how to pack. With the genetic instructions for the next generation folded just so, snuggled into a custom-made outer covering studded with cell-grabbing proteins, these tiny invaders quest for new digs on the reg.

30 Aug 2022

The effects of amino acid substitutions on the affinity of the SARS-CoV-2 spike RBD to the human receptor hACE2

Researchers performed a structural bioinformatics analysis to evaluate the binding energy of the SARS-CoV-2 Omicron variants of concern spike protein receptor-binding domain to human angiotensin-converting enzyme 2 receptor compared to other VOCs.

30 Aug 2022

Study reveals a 'stealing' mechanism that contributes to antibody diversity

A few years ago, Professor Kathrin de la Rosa and her colleagues in the lab of the Swiss immunologist Antonio Lanzavecchia made an unusual discovery.

29 Aug 2022

IBS discussed collaboration with NIAID and St. Jude’s Children’s Research Hospital

The Institute for Basic Science recently visited the National Institutes of Health and announced its collaboration with St. Jude Children's Research Hospital in the U.S., with the aims of increasing virus research capacity and ability to respond to infectious disease outbreaks.

29 Aug 2022

Viruses modify host cellular machinery to produce high amounts of viral progeny

The study, published in Nature Communications, shows a new mechanism whereby viruses modify cellular machinery so that it can better read the instructions in the genome of the invading virus.

29 Aug 2022

Single mutation in Kcnc3 gene causes learning deficits in mice

A single mutation in a gene, Kcnc3, which encodes a potassium channel in neurons, causes learning deficits in mice, UT Southwestern researchers report in a new study in PNAS.

29 Aug 2022

Researchers identify multiple genes and rare variants linked with Crohn's disease susceptibility

An international consortium of researchers has identified genetic variants in 10 genes that elevate a person's susceptibility to Crohn's disease, a form of inflammatory bowel disease.

29 Aug 2022

Researchers receive $1.2 million Keck Foundation grant to find molecules for targeting the 'undruggable proteome'

The W.M. Keck Foundation has awarded a $1.2 million grant to medicinal chemistry and computational biology researchers at the University of Kansas and the University of Chicago focused on addressing a long-unresolved problem in biomedical research - finding molecules able to target the "undruggable proteome."

29 Aug 2022

Researchers propose a novel, non-discriminatory classification of the monkeypox virus

Researchers proposed a novel, non-discriminatory classification of the monkeypox virus.

29 Aug 2022

What is the impact of the SARS-CoV-2 omicron wave in South Africa?

A new study has described the transmissibility of SARS-CoV-2, population-level immunity, and impact of omicron wave in South Africa.

27 Aug 2022

UB study reveals a mechanism of gene evolution generating mucin function

From the slime coating slugs to the saliva in our mouths, many slippery bodily fluids contain mucus. So how did this marvel of biology evolve?

26 Aug 2022

Discovery may lead to the development of new systems of antifungal drugs

Mycosis is an infectious disease caused by parasitic mold or yeast and treated with an antifungal, a subgroup of antibiotics.

26 Aug 2022

New study provides comparison of replicating and non-replicating vaccines against SARS-CoV-2

A new study reported a single-cell adenovirus (SC-Ad) which replicates the antigen genes substantially without producing infectious progeny.

26 Aug 2022

Cornell research offers insights into CRISPR RNA-guided Caspase system

New research from Cornell offers insights into a line of CRISPR systems, which could lead to promising antiviral and tissue engineering tools in animal and plants.

25 Aug 2022

New approach using CRISPR can engineer massive quantities of cells for therapeutic applications

A new variation of the CRISPR-Cas9 gene editing system makes it easier to re-engineer massive quantities of cells for therapeutic applications.

25 Aug 2022

Investigating the links between the rate of new cases, mutations, and selection in SARS-CoV2 virus

How many times in the last 18 months have you seen a map that looks like the one above? It looks like a population density map, but in fact, it is a case total for the COVID19 rates from Johns Hopkins Coronavirus Research Center (collected on 24 May 2022).

25 Aug 2022

Genome News and Research

Understanding recombination rates in RNA viruses

Disrupting a virus’s genome packaging can halt replication, study finds

The effects of amino acid substitutions on the affinity of the SARS-CoV-2 spike RBD to the human receptor hACE2

Study reveals a 'stealing' mechanism that contributes to antibody diversity

IBS discussed collaboration with NIAID and St. Jude’s Children’s Research Hospital

Viruses modify host cellular machinery to produce high amounts of viral progeny

Single mutation in Kcnc3 gene causes learning deficits in mice

Researchers identify multiple genes and rare variants linked with Crohn's disease susceptibility

Researchers receive $1.2 million Keck Foundation grant to find molecules for targeting the 'undruggable proteome'

Researchers propose a novel, non-discriminatory classification of the monkeypox virus

What is the impact of the SARS-CoV-2 omicron wave in South Africa?

UB study reveals a mechanism of gene evolution generating mucin function

Discovery may lead to the development of new systems of antifungal drugs

New study provides comparison of replicating and non-replicating vaccines against SARS-CoV-2

Cornell research offers insights into CRISPR RNA-guided Caspase system

New approach using CRISPR can engineer massive quantities of cells for therapeutic applications

Investigating the links between the rate of new cases, mutations, and selection in SARS-CoV2 virus

SARS-CoV-2 mutational spectra based on reconstructed phylogenetic tree

Virtual screening and molecular dynamics explore potential repurposed drugs against monkeypox virus

Researchers discover a new class of more potent and less toxic drugs for leukemia patients

Genetics & Genomics - Second Edition eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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