Preclinical News and Research

RSS

The Pancreatic Cancer Collective awards additional funding of $16 million for new therapies

The Pancreatic Cancer Collective, the strategic partnership of Lustgarten Foundation and Stand Up To Cancer, has awarded additional funding of up to $16 million to four teams of top researchers as part of its "New Therapies Challenge Grants," the American Association for Cancer Research, Scientific Partner of SU2C, announced today.

5 Mar 2020

Study provides new insight into neurofibromin-deficient ER+ breast cancer

An international team of researchers led by scientists at Baylor College of Medicine has new insights into the function of neurofibromin, a tumor suppressor produced by the NF1 gene.

5 Mar 2020

Novel compounds show promise as potent new treatment for malaria

A novel class of antimalarial compounds that can effectively kill malaria parasites has been developed by Australian and US researchers.

4 Mar 2020

Preclinical data of Ocugen's OCU400 genetic modifier published in Nature Gene Therapy

Ocugen, Inc., a clinical-stage company focused on discovering, developing and commercializing transformative therapies to treat rare and underserved ophthalmic diseases, announced today the publication in Nature Gene Therapy of preclinical data of nuclear hormone receptor gene NR2E3 as a genetic modifier and therapeutic agent to treat multiple retinal degenerative diseases.

3 Mar 2020

The research and development costs of a new drug

Many recent studies have focused on how much it costs to bring a new drug to market in the light of increasing drug prices. Estimates range from $314 million to $2.8 billion. Most of this was based on proprietary data and was, therefore, not verifiable independently, attracting much criticism.

3 Mar 2020

Obesity could increase severity of influenza study shows

A new study has revealed that those who are obese or overweight tend to get more severe bouts of influenza than those who are a healthy weight. The reason behind this could be the altered immune system of those who are obese. The study outlining this finding is published in the latest issue of the journal mBio from the American Society for Microbiology (ASM). The study was titled, "Obesity-Related Microenvironment Promotes Emergence of Virulent Influenza Virus Strains."

3 Mar 2020

Researchers identify major landmarks of peripheral artery disease recovery

Novel biomedical advances that show promise in the lab often fall short in clinical trials. For researchers studying peripheral artery disease, this is made more difficult by a lack of standardized metrics for what recovery looks like.

2 Mar 2020

Researchers develop multi-organ-on-a-chip for drug toxicity screening

Researchers in the US have developed a new multi-organ-on-a-chip to test how new drugs affect the human body's vital organs.

2 Mar 2020

Experimental drug offers hope for improving movement symptoms of Parkinson's

Results from a study looking at an experimental drug to tackle the debilitating side effect of dyskinesia, have offered hope that it may have potential as a future treatment for people with Parkinson's.

2 Mar 2020

Two Wake Forest Baptist scientists receive $1.5 million for cancer research

Two scientists from Wake Forest School of Medicine, part of Wake Forest Baptist Health, have received a total of $1.5 million in research funding from the American Cancer Society to study new chemotherapy and immunotherapy treatments for cancer.

28 Feb 2020

Boehringer Ingelheim and Trutino enter into research collaboration to advance cytokine therapies

Boehringer Ingelheim and Trutino Biosciences today announced they have entered into a research collaboration and worldwide licensing agreement based on Trutino’s innovative On-Demand-Cytokine platform.

From Boehringer Ingelheim International GmbH 28 Feb 2020

New immunotherapeutic strategy shows promise to fight off infectious biofilms

The same way baking soda breaks down grease and grime, making surfaces easier to clean, researchers at the Lewis Katz School of Medicine at Temple University now show that a new therapeutic molecule can break apart communities of harmful bacteria, opening the way for bacteria-killing antibiotics to more effectively clear out infections.

27 Feb 2020

APEIRON Biologics launches clinical trial of respiratory drug to treat coronavirus infection

APEIRON Biologics AG, a biotechnology company with an approved product on the market as well as a broad preclinical and clinical pipeline, today announced the launch of a Pilot investigator-initiated clinical trial with APN01, a recombinant human angiotensin-converting enzyme 2, to treat patients with severe coronavirus infection in the People's Republic of China.

26 Feb 2020

Cellular metabolism plays key role in dictating the fate decision between pathogenic and regulatory T cells

Patients with autoimmune diseases like multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis have an imbalance between two types of immune system T cells.

26 Feb 2020

Targeting overactive immune cells with experimental drug could improve TBI symptoms

Researchers at the University of Maryland School of Medicine found that targeting overactive immune cells in the brain with an experimental drug could limit brain cell loss and reverse cognitive and motor difficulties caused by traumatic brain injury.

25 Feb 2020

UCI neuro-oncologist uses comprehensive approach to battle brain cancer

When you're facing a cancer diagnosis with an average survival span of 12 to 18 months, every milestone is a victory.

23 Feb 2020

Study exposes the Achilles' heel of deadly ccRCC tumors

An experimental drug already shown to be safe and help some patients with clear cell renal cell carcinoma, a deadly form of kidney cancer, effectively disables its molecular target.

20 Feb 2020

Targeted combinatorial drug treatment restores beta cell function in mice

The loss of the identity of insulin-secreting beta cells in the islet of Langerhans, a process also called beta cell dedifferentiation, has been proposed to be a main reason for the development of diabetes.

20 Feb 2020

An enriched environment helps heal young, injured brains

An enriched environment--with increased opportunities for physical activity, socialization and exploring novel stimuli--helped lessen functional, anatomical and cellular deficits in an experimental model of brain damage caused by oxygen deprivation at birth.

19 Feb 2020

MILabs achieves breakthrough in preclinical oncology imaging by eliminating positron range blurring effect

Researchers at MILabs B.V. have succeeded at imaging the popular Zirconium-89 isotope in small animals of human disease at very high resolutions (<0.75 mm).

19 Feb 2020

Preclinical News and Research

The Pancreatic Cancer Collective awards additional funding of $16 million for new therapies

Study provides new insight into neurofibromin-deficient ER+ breast cancer

Novel compounds show promise as potent new treatment for malaria

Preclinical data of Ocugen's OCU400 genetic modifier published in Nature Gene Therapy

The research and development costs of a new drug

Obesity could increase severity of influenza study shows

Researchers identify major landmarks of peripheral artery disease recovery

Researchers develop multi-organ-on-a-chip for drug toxicity screening

Experimental drug offers hope for improving movement symptoms of Parkinson's

Two Wake Forest Baptist scientists receive $1.5 million for cancer research

Boehringer Ingelheim and Trutino enter into research collaboration to advance cytokine therapies

New immunotherapeutic strategy shows promise to fight off infectious biofilms

APEIRON Biologics launches clinical trial of respiratory drug to treat coronavirus infection

Cellular metabolism plays key role in dictating the fate decision between pathogenic and regulatory T cells

Targeting overactive immune cells with experimental drug could improve TBI symptoms

UCI neuro-oncologist uses comprehensive approach to battle brain cancer

Study exposes the Achilles' heel of deadly ccRCC tumors

Targeted combinatorial drug treatment restores beta cell function in mice

An enriched environment helps heal young, injured brains

MILabs achieves breakthrough in preclinical oncology imaging by eliminating positron range blurring effect

New Approach Methodologies, the 3Rs and Multimodal Imaging in Preclinical Research - eBook eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics