Apolipoprotein News and Research

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Researchers identify antibody that removes amyloid plaques without the risk of brain bleeds

As people age, a normal brain protein known as amyloid beta often starts to collect into harmful amyloid plaques in the brain. Such plaques can be the first step on the path to Alzheimer's dementia.

18 Feb 2021

Lewy body dementia may share similar genetic profiles with Alzheimer's disease

In a study led by National Institutes of Health (NIH) researchers, scientists found that five genes may play a critical role in determining whether a person will suffer from Lewy body dementia, a devastating disorder that riddles the brain with clumps of abnormal protein deposits called Lewy bodies.

17 Feb 2021

Early plasma markers help track the progression of Alzheimer's disease

A Quebec research team has discovered two early plasma markers to detect Alzheimer's disease five years before its onset.

28 Jan 2021

Can metabolic biomarkers help clinicians stratify adverse outcome risk in COVID-19 patients?

A recent study describes the alterations in lipids and other parameters that define the state of dysfunctional metabolism in acute COVID-19 illness.

20 Jan 2021

HDL nanoparticles prevent cholesterol movement at membrane receptor to inhibit entry of SARS-CoV-2 pseudovirus in cell culture

As researchers strive to find safe therapeutics for COVID 19, a study suggests that preventing the movement of cholesterol may inhibit viral entry by up to 80%.

17 Dec 2020

RNA editing within host linked to SARS-CoV-2 variants

Since the start of the COVID-19 pandemic, the causative virus, SARS-CoV-2, has undergone several mutations.

14 Dec 2020

Researchers identify new gene variants that modify the risk of late-onset Alzheimer's disease

Late-onset Alzheimer's disease (LOAD) is the most common form of dementia in the elderly, affecting almost 44 million people worldwide.

8 Dec 2020

Metabolic biomarkers could predict COVID-19 severity

A new study suggests that metabolic biomarkers could possibly predict the severity of COVID-19 in patients.

16 Nov 2020

Genetic risk scoring of lipoprotein(a) can predict risk of atherosclerotic cardiovascular disease

Elevated levels of a little-known lipoprotein in the blood that may put people at high risk of cardiovascular disease can be as accurately detected by genetic testing as by conventional laboratory measurement, researchers at Massachusetts General Hospital (MGH) have found.

6 Oct 2020

Study provides valuable insights on effects of APOE gene on health and disease

From Alzheimer's to obesity, life can change dramatically if you discover you have a genetic risk of disease. Now, a new study from the Australian Centre for Precision Health, University of South Australia is challenging these predispositions, showing that some of the genes traditionally labelled as 'bad' are not always what they seem.

16 Sep 2020

Genetic risk factor for late-onset Alzheimer's disease has early effects on the brain

A genetic predisposition to late-onset Alzheimer's disease affects how the brains of young adults cope with certain memory tasks.

15 Sep 2020

Host gene editing main driving force of SARS-CoV-2 mutations

A new study published on the aRxiv preprint server in September 2020 shows that the host immune response, mediated by two RNA editors, causes the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to adapt and change strain characteristics.

9 Sep 2020

People with genetic risk for Alzheimer's have spatial navigation problems

An international research team headed by Anne Bierbrauer, Dr. Lukas Kunz, Dr. Carlos Gomez and Professor Nikolai Axmacher from Ruhr-Universität Bochum and Universitätsklinikum Freiburg now reports that problems in spatial navigation can also be detected in people with a genetic risk for Alzheimer's.

31 Aug 2020

Alzheimer's risk and navigation problems go hand in hand

Animals and humans have the ability to follow their own position in space through self-motion cues, even in the absence of any other sensory information.

31 Aug 2020

Two lipid-binding proteins in mitochondria control overall stability of protein complexes

Mitochondria are the powerhouse of cells which continuously convert energy from food into the chemical energy currency called ATP.

12 Aug 2020

Research identifies a potential therapeutic target for clogged arteries

New work led by Carnegie's Meredith Wilson and Steve Farber identifies a potential therapeutic target for clogged arteries and other health risks that stem from an excess of harmful fats in the bloodstream. Their findings are published by PLOS Genetics.

7 Aug 2020

Study shows favorable cardiovascular health lowers risk of dementia

Genes and cardiovascular health each contribute in an additive way to a person's risk of dementia, U.S. researchers including Sudha Seshadri, MD, and Claudia Satizabal, PhD, of The University of Texas Health Science Center at San Antonio (UT Health San Antonio) reported July 20 in the journal Neurology.

21 Jul 2020

A new strategy to combat treatment resistance in choroidal neovascularization

An international team of researchers led by Baylor College of Medicine and Houston Methodist has discovered a strategy that can potentially address a major challenge to the current treatment for choroidal neovascularization (CNV), an aggressive form of age-related macular degeneration, the leading cause of irreversible blindness in the elderly.

16 Jul 2020

Study shows why ApoE4 increases risk of Alzheimer's disease

Apolipoprotein E (ApoE) is kind of like a delivery service for the human brain. It supplies neurons with important nutrients, including with polyunsaturated fatty acids - which are building blocks of the membranes surrounding the neurons.

26 Jun 2020

Tracing coronavirus habitats with genomics

Now, a new study by researchers at the University of Ottawa and published on the preprint server bioRxiv in June 2020 reports the differences in genomes of viruses that are exposed to antiviral proteins vs. those that are not. This host-derived pressure on the virus to adapt may help devise newer ways to build an effective vaccine.

15 Jun 2020