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African nations must take ownership of HIV response to reduce disease burden

Africa must take ownership of its HIV response, write Izukanji Sikazwe and Magda Robalo, co-chairs of the African-led HIV Control Working Group.

9 Oct 2024

Collaborative efforts essential for tackling dementia in Africa

Dementia is becoming a major public health issue in Africa as its population ages.

9 Oct 2024

Understanding proteasome function in Trichomonas vaginalis for drug development

Researchers from IOCB Prague are furthering the understanding of how medicines work and what it takes to develop their most effective variants.

8 Oct 2024

Revolutionizing drug discovery with SmartCADD

Drug discovery is much like working a jigsaw puzzle. The chemical compounds behind drug molecules must be shaped to fit with the proteins in our bodies to produce therapeutic effects.

8 Oct 2024

Doxycycline increases antimicrobial resistance in the gut without disrupting microbiome diversity

Doxycycline post-exposure prophylaxis increases tetracycline resistance genes in the gut, without significantly affecting microbiome diversity in men who have sex with men and transgender women.

7 Oct 2024

New research highlights the impact of stigma on health equity

A new article published in Nature Reviews Disease Primers underscores the profound role that stigma can play in health care -- and how addressing stigma-related barriers can significantly improve health outcomes for individuals and communities around the world.

7 Oct 2024

Dronabinol shows promise in reducing agitation in Alzheimer's patients

In a study led by the Johns Hopkins University School of Medicine and Tufts University School of Medicine, researchers show that a pill form of the drug dronabinol, an FDA-approved synthetic version of marijuana's main ingredient, THC, reduces agitation in patients with Alzheimer's by an average of 30%.

2 Oct 2024

Long-lived plasma cells fail to establish after COVID mRNA vaccination, limiting long-term antibody response

Researchers found that SARS-CoV-2-specific plasma cells were largely excluded from the long-lived plasma cell compartment in the bone marrow after mRNA vaccination, explaining the short-lived antibody response.

2 Oct 2024

Over 80% of women are iron deficient by their third trimester

Iron deficiency is prevalent among pregnant women, impacting health outcomes. This study emphasizes the importance of monitoring and nutrition during pregnancy.

30 Sep 2024

COVID-19 pandemic reduced sexual partners and activity in the U.S.

The COVID-19 pandemic significantly reduced the number of sexual partners and sexual encounters in the U.S., with non-married women experiencing the most pronounced declines.

24 Sep 2024

WHO calls for action to support adolescent mental and sexual health

Increased investment is urgently needed to address evolving health risks and meet the mental and sexual and reproductive health needs for the nearly 1.3 billion adolescents (aged 10-19 years) globally, according to a new scientific publication released by the World Health Organization (WHO).

23 Sep 2024

New two-dose HIV vaccine strategy shows promise for stronger immune response

One major reason why it has been difficult to develop an effective HIV vaccine is that the virus mutates very rapidly, allowing it to evade the antibody response generated by vaccines.

20 Sep 2024

Collaborative study offers hope for syphilis vaccine development

Syphilis cases have surged worldwide, leaving public health officials scrounging for ways to stop the spread. Now, a large, collaborative study of syphilis genetics from four continents has found hints of a possible target for a vaccine.

19 Sep 2024

Antibiotic resistance threatens millions of lives worldwide

More than 39 million people around the world could die from antibiotic-resistant infections over the next 25 years, according to a study published in The Lancet.

18 Sep 2024

New insights into the mechanisms of efavirenz-induced neurotoxicity

Efavirenz is an important drug for treating HIV infection, but it has negative effects that can significantly impact patients' quality of life over time. It causes neuropsychiatric disorders and neurocognitive impairment in roughly 50 percent of patients. The drug is associated with abnormal lipid levels in blood plasma, but the molecular mechanisms responsible for negative clinical observations are unknown.

18 Sep 2024

Tossed medicine, delayed housing: How homeless sweeps are thwarting Medicaid’s goals

Andrew Douglass shoved his clothes and belongings into plastic trash bags as five police officers surrounded his encampment — a drab gray tent overflowing along a bustling sidewalk in the gritty Tenderloin neighborhood, where homeless people lie sprawled on public sidewalks, sometimes in drug overdoses.

16 Sep 2024