Splicing News and Research

RSS

Researchers demonstrate accurate identification of amino acids

Some three billion base pairs make up the human genome-the floor plan of life. In 2003, the Human Genome Project announced the successful decryption of this code, a tour de force that continues to supply a stream of insights relevant to human health and disease.

7 Apr 2014

Too little or too much of SRPK1 enzyme promotes cancer, shows research

Researchers at the University of California, San Diego School of Medicine have found that too little or too much of an enzyme called SRPK1 promotes cancer by disrupting a regulatory event critical for many fundamental cellular processes, including proliferation.

4 Apr 2014

Mayo Clinic researchers shed light on new mechanism by which prostate cancer develops in men

Mayo Clinic researchers have shed light on a new mechanism by which prostate cancer develops in men. Central to development of nearly all prostate cancer cases are malfunctions in the androgen receptor - the cellular component that binds to male hormones.

11 Feb 2014

Splicing findings offer lung cancer clues

Researchers from Spain have identified several new splicing events regulated by the oncogenic splicing factor SRSF1 in lung cancer, suggesting that their dysregulation is involved in the pathogenesis of the disease.

4 Feb 2014

Splicing factor SRSF6 promotes hyperplasia of sensitized skin

Normally, tissue injury triggers a mechanism in cells that tries to repair damaged tissue and restore the skin to a normal, or homeostatic state. Errors in this process can give rise to various problems, such as chronic inflammation, which is a known cause of certain cancers.

21 Jan 2014

Scientists reveal atomic-level view of genetic defect that causes myotonic dystrophy type 2

Scientists from the Florida campus of The Scripps Research Institute have revealed an atomic-level view of a genetic defect that causes a form of muscular dystrophy, myotonic dystrophy type 2, and have used this information to design drug candidates with potential to counter those defects—and reverse the disease.

6 Jan 2014

Cleveland Clinic researchers elected as AAAS Fellows for excellent contributions to science

Cleveland Clinic researchers Richard A. Padgett, Ph.D., and Edward F. Plow, Ph.D., have been named Fellows of the American Association for the Advancement of Science (AAAS). This year's AAAS Fellows will be formally announced in the AAAS News & Notes section of the journal Science on Nov. 29, 2013.

26 Nov 2013

Study uncovers novel mechanism that helps govern regulated gene expression

A study led by researchers at the University of California, San Diego School of Medicine shines a new light on molecular tools our cells use to govern regulated gene expression. The study was published on line in advance of print November 10 in the journal Nature Structural and Molecular Biology.

13 Nov 2013

New study could help lead to prevention and treatment of heart failure in diabetics

Researchers from the University of Texas Medical Branch at Galveston have discovered one of the pathogenic components of diabetes in the heart, as published in the Journal of Biological Chemistry.

7 Nov 2013

Scientists unravel secrets of mechanism that snips our genes

Certain diseases such as cystic fibrosis and muscular dystrophy are linked to genetic mutations that damage the important biological process of rearranging gene sequences in pre-messenger RNA, a procedure called RNA splicing.

27 Sep 2013

Study indicates that RNA translation is dictated by translational hotspots

Protein synthesis in the extensions of nerve cells, called dendrites, underlies long-term memory formation in the brain, among other functions. "Thousands of messenger RNAs reside in dendrites, yet the dynamics of how multiple dendrite messenger RNAs translate into their final proteins remain elusive," says James Eberwine, PhD, professor of Pharmacology, Perelman School of Medicine at the University of Pennsylvania, and co-director of the Penn Genome Frontiers Institute.

27 Sep 2013

UCSF inaugurates new endowment of PhD education programs in basic sciences

Sequoia Capital Chairman Sir Michael Moritz, KBE, and his wife, Harriet Heyman, in collaboration with UC San Francisco, have kicked off a new endowment with a $60 million contribution to ensure the future of PhD education programs in the basic sciences.

25 Sep 2013

Researchers identify alterations in proteins responsible for RNA splicing in Alzheimer's

Researchers at Emory University School of Medicine's Alzheimer's Disease Research Center have identified a previously unrecognized type of pathology in the brains of patients with Alzheimer's disease.

11 Sep 2013

Researchers develop TSUNAMI method to create animal model of adult-onset version of SMA

A research team at Cold Spring Harbor Laboratory has used a recently developed technology they call TSUNAMI to create the first animal model of the adult-onset version of spinal muscular atrophy, a devastating motor-neuron illness.

10 Sep 2013

Scientists identify RNA regulator that plays critical role in proper functioning of hESCs

Scientists at A*STAR's Genome Institute of Singapore, in collaboration with their counterparts from Canada, Hong Kong and US, have discovered a protein mediator SON plays a critical role in the health and proper functioning of human embryonic stem cells. This finding was reported on 8th September 2013 in the advanced online issue of the prestigious science journal Nature Cell Biology.

10 Sep 2013

UTHealth researchers find cause for rare type of bleeding disorder

Fifteen years ago, a hematologist came to Dianna Milewicz, M.D., Ph.D., with a puzzle: Multiple generations of an East Texas family suffered from a moderately severe bleeding disorder, but it wasn't hemophilia.

28 Aug 2013

Medical investigators discover new aspect of gene-splicing process that produces mRNA

A rare, small RNA turns a gene-splicing machine into a switch that controls the expression of hundreds of human genes. Howard Hughes Medical Institute Investigator and professor of Biochemistry Gideon Dreyfuss, PhD, and his team from the Perelman School of Medicine at the University of Pennsylvania, discovered an entirely new aspect of the gene-splicing process that produces messenger RNA (mRNA).

22 Aug 2013

Brain tumor cells in arrested development contribute to cell variety that protects cancer

A program that pushes immature cells to grow up and fulfill their destiny as useful, dedicated cells is short-circuited in the most common and deadly form of brain tumor, scientists at The University of Texas MD Anderson Cancer Center report this week in the Early Edition of the Proceedings of the National Academy of Sciences.

8 Aug 2013

Novel way to dramatically raise potency of drug candidates targeting RNA

Scientists from the Jupiter campus of The Scripps Research Institute (TSRI) have shown a novel way to dramatically raise the potency of drug candidates targeting RNA, resulting in a 2,500-fold improvement in potency and significantly increasing their potential as therapeutic agents.

6 Aug 2013

ASH to award 2013 William Dameshek Prize to Andrew S. Weyrich

The American Society of Hematology will present the 2013 William Dameshek Prize to Andrew S. Weyrich, PhD, of The University of Utah for his seminal research on the cellular and molecular causes of blood clots.

2 Aug 2013