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MSK begins CAR T cell clinical trial for children with relapsed or treatment-resistant ALL

Researchers from Memorial Sloan Kettering Cancer Center are pioneering a new groundbreaking clinical trial for children and young adults with relapsed or treatment-resistant acute lymphocytic leukemia (ALL) by using one of the most promising methods of cancer treatment today, chimeric antigen receptor (CAR) T cells.

12 Apr 2015

Study explores the impact of costly hepatitis C drugs on Rhode Island's prison system

A new study finds that effective new hepatitis C drugs are so expensive the state of Rhode Island would have to spend almost twice its entire prison health budget to treat all its chronically infected inmates.

10 Apr 2015

Fewer patients take effective gout drug after steep price increase

Study finds that fewer patients with gout received useful colchicine drug after FDA actions led to 50x increase in price.

10 Apr 2015

HeartWare International gets approval to market HeartWare Ventricular Assist System in Canada

HeartWare International, Inc., a leading innovator of less invasive, miniaturized circulatory support technologies that are revolutionizing the treatment of advanced heart failure, today announced that it has received approval from Health Canada, the country's federal department responsible for helping Canadians maintain their health, to market the HeartWare Ventricular Assist System as a bridge to heart transplantation in patients with end-stage heart failure.

9 Apr 2015

Study may point to immediate cause of CF exacerbations

In the genetic disorder cystic fibrosis (CF), the most severe symptoms are recurring episodes of lung inflammation and bacterial infection (known as "exacerbations") that happen from one to three times a year and cause ever-increasing amounts of lung damage through the course of a CF patient's life.

9 Apr 2015

Cedars-Sinai Heart Institute sets new national standard for most adult heart transplants

The Cedars-Sinai Heart Institute completed 120 adult heart transplants and two adult heart-lung transplants in 2014, setting a new national standard for the most adult heart transplants performed in a single year.

9 Apr 2015

Phase 2 IMAGO trial of SHP625 fails to meet primary endpoints in pediatric patients with ALGS

Shire plc today announced that the 13-week Phase 2 IMAGO trial of its investigational compound SHP625 (LUM001) did not meet the primary or secondary endpoints in the study of 20 pediatric patients with Alagille syndrome (ALGS), a rare, life-threatening genetic disorder that presents with chronic cholestasis (accumulation of bile acids in the liver) and severe pruritus (itching).

9 Apr 2015

Study: Standard nursing assessments may help improve outcomes in cirrhosis patients

Patients hospitalized with advanced cirrhosis, a chronic and degenerative disease of the liver, are at increased risk of death. The tools currently used to assess that risk are limited in predicting which patients will need a liver transplant and which will be healthy enough to survive transplantation.

8 Apr 2015

New simeprevir clinical data to be presented at EASL's International Liver Congress 2015

Janssen Sciences Ireland UC, one of the Janssen Pharmaceutical Companies of Johnson & Johnson, today announced that clinical data for simeprevir, its NS3/4A protease inhibitor for the treatment of hepatitis C virus (HCV) infection, will be presented at The International Liver Congress 2015 of the European Association for the Study of the Liver taking place in Vienna from April 22-26.

8 Apr 2015

Scientists discover molecular switch that ‘turns off’ HCMV

Human cytomegalovirus (HCMV) is an extremely common virus, which as other members of the herpes virus family causes life-long infections in humans. Most individuals are exposed to HCMV during childhood, yet symptoms can be easily fought off by a healthy immune system.

7 Apr 2015

Clinical trial uses personalized cellular therapy to treat GVHD complication of bone marrow transplant

An innovative clinical trial using the science of "personalized" cellular therapy has begun enrolling children and adults suffering from graft-versus-host-disease (GVHD), a life-threatening complication of bone marrow transplantation in which donor immune lymphocytes attack the organs of the bone marrow transplant recipient.

3 Apr 2015

Thoratec gets final FDA approval to expand enrollment of HeartMate III U.S. clinical trial

Thoratec Corporation, a world leader in device-based mechanical circulatory support therapies to save, support and restore failing hearts, today announced that it received final approval from the FDA to broaden enrollment of the HeartMate III U.S. clinical trial of up to 1,028 patients in up to 60 sites.

2 Apr 2015

FGF21 protein can boost regenerative effects of human PPARα

Researchers at UC Davis have illuminated an important distinction between mice and humans: how human livers heal. The difference centers on a protein called PPARα, which activates liver regeneration. Normally, mouse PPARα is far more active and efficient than the human form, allowing mice to quickly regenerate damaged livers.

1 Apr 2015

Drug-resistant E. coli outbreak linked to contaminated endoscopes in Washington state hospital

An outbreak of a novel Escherichia coli (E. coli) strain resistant to antibiotics has been linked to contaminated endoscopes in a Washington state hospital. The study indicates that industry standard cleaning guidelines, which were exceeded by hospital staff, may not be sufficient for sterilizing endoscopes adequately.

31 Mar 2015

Fujifilm enters into definitive agreement to acquire Cellular Dynamics International

FUJIFILM Holdings Corporation (President: Shigehiro Nakajima) and Cellular Dynamics International, Inc. (CEO: Robert J. Palay), a leading developer and manufacturer of fully functioning human cells in industrial quantities to precise specifications, today announced that the two companies have entered into a definitive agreement whereby Fujifilm will acquire CDI via an all-cash tender offer to be followed by a second step merger.

30 Mar 2015

Fecal microbiota transplantation more successful for treating Clostridium difficile infections

Distasteful though it sounds, the transplantation of fecal matter is more successful for treating Clostridium difficile infections than previously thought.

30 Mar 2015

Women face Lymphangioleiomyomatosis risk during their childbearing years

A rare and potentially deadly lung disease called Lymphangioleiomyomatosis (LAM) strikes women during their childbearing years.

29 Mar 2015

Study shows high-fat diet may increase risk for depression, psychiatric disorders

Can the consumption of fatty foods change your behavior and your brain? High-fat diets have long been known to increase the risk for medical problems, including heart disease and stroke, but there is growing concern that diets high in fat might also increase the risk for depression and other psychiatric disorders.

26 Mar 2015

Mesenchymal stem cell transplantation reduces opioid tolerance, opioid-induced pain

Mesenchymal stem cell (MSC) transplantation reduced opioid tolerance and opioid-induced hyperalgesia caused by daily morphine injections in rats, according to new research.

25 Mar 2015

Testing APOL1 gene variants in deceased kidney donors may improve transplant outcomes

Kidney transplantation outcomes from deceased African-American donors may improve through rapid testing for apolipoprotein L1 gene (APOL1) renal risk variants at the time of organ recovery, according to a new study led by researchers at Wake Forest Baptist Medical Center.

25 Mar 2015

Transplant News and Research

MSK begins CAR T cell clinical trial for children with relapsed or treatment-resistant ALL

Study explores the impact of costly hepatitis C drugs on Rhode Island's prison system

Fewer patients take effective gout drug after steep price increase

HeartWare International gets approval to market HeartWare Ventricular Assist System in Canada

Study may point to immediate cause of CF exacerbations

Cedars-Sinai Heart Institute sets new national standard for most adult heart transplants

Phase 2 IMAGO trial of SHP625 fails to meet primary endpoints in pediatric patients with ALGS

Study: Standard nursing assessments may help improve outcomes in cirrhosis patients

New simeprevir clinical data to be presented at EASL's International Liver Congress 2015

Scientists discover molecular switch that ‘turns off’ HCMV

Clinical trial uses personalized cellular therapy to treat GVHD complication of bone marrow transplant

Thoratec gets final FDA approval to expand enrollment of HeartMate III U.S. clinical trial

FGF21 protein can boost regenerative effects of human PPARα

Drug-resistant E. coli outbreak linked to contaminated endoscopes in Washington state hospital

Fujifilm enters into definitive agreement to acquire Cellular Dynamics International

Fecal microbiota transplantation more successful for treating Clostridium difficile infections

Women face Lymphangioleiomyomatosis risk during their childbearing years

Study shows high-fat diet may increase risk for depression, psychiatric disorders

Mesenchymal stem cell transplantation reduces opioid tolerance, opioid-induced pain

Testing APOL1 gene variants in deceased kidney donors may improve transplant outcomes

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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