Preclinical News and Research

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Human organ chips for better drug development

The process of developing new drugs is both difficult and costly. It is estimated that of all the drug candidates which start out on their testing journey, less than 14% actually make it to the clinical scene and receive approval by the US Food and Drug Administration (FDA).

27 Jan 2020

Improving drug testing with comprehensive 'Organ Chip' platform

The U.S. Food and Drug Administration approves only 13.8% of all tested drugs, and these numbers are even lower in "orphan" diseases that affect relatively few people.

27 Jan 2020

Medtronic: RCT demonstrates profound back pain relief with DTM therapy

Medtronic plc today announced three-month results from a large, multicenter randomized controlled trial showing statistically significant (p=0.0009) and superior back pain relief with Differential Target Multiplexed (DTM) Spinal Cord Stimulation (SCS) compared to conventional SCS.

From Medtronic 27 Jan 2020

Robotic heart to replace human transplants on the horizon

Scientists are working to end the need for human heart transplants by 2028. A team of researchers in the UK, Cambridge, and the Netherlands are developing a robot heart that can pump blood through the circulatory network but is soft and pliable. The first working model should be ready for implantation into animals within the next 3 years, and into humans within the next 8 years.

26 Jan 2020

A microdose lithium formulation could halt signs of Alzheimer's pathology

There remains a controversy in scientific circles today regarding the value of lithium therapy in treating Alzheimer's disease.

24 Jan 2020

Injecting nanoparticles into the bloodstream to reduce brain swelling after traumatic brain injury

After a traumatic brain injury, the most harmful damage is caused by secondary swelling of the brain compressed inside the skull. There is no treatment for this.

22 Jan 2020

Study: Non-medical cannabis use is more common in adults suffering from pain

A new study from researchers at Columbia University Vagelos College of Physicians and Surgeons found that non-medical cannabis use--including frequent or problematic use--is significantly more common in adults with pain than in those without pain.

22 Jan 2020

FDA-approved medication for opioid addiction is increasing except in the youngest group

An analysis of national data on buprenorphine use found that treatment with the FDA-approved medication for opioid addiction is increasing in all age groups except the young (age 15-24 years), in whom use of the medication is decreasing.

21 Jan 2020

Novel drug inhibits liver damage, obesity and glucose intolerance in mice fed with high-fat diet

Mice given a new drug targeting a key gene involved in lipid and glucose metabolism could tolerate a high-fat diet regimen (composed of 60% fat from lard) without developing significant liver damage, becoming obese, or disrupting their body's glucose balance.

20 Jan 2020

Research collaboration reveals potential treatment option for incurable blood cancers

Today, OncoTartis, Inc. and Children's Cancer Institute jointly announced the publication of two research manuscripts in a leading onco-hematological journal Leukemia, both devoted to the OncoTartis' clinical drug candidate OT-82.

16 Jan 2020

Essential tremor caused by overactive brain waves

The source of essential tremor--a movement disorder that causes involuntary trembling of the hands, arms, and head--has been enigmatic, impeding the development of effective treatments for a condition that affects 4% of people over 40.

16 Jan 2020

Erythropoietin treatment may not provide neuroprotection for preemies

A study published in the Jan 16 edition of the New England Journal of Medicine suggests that erythropoietin treatment may not provide neuroprotection for extremely premature babies.

16 Jan 2020

Study shows superior functionality of Duodenum Intestine-Chip populated with organoids

Emulate, Inc. announced today a published study in collaboration with Johns Hopkins University School of Medicine, that demonstrated superior functionality of the Duodenum Intestine-Chip populated with organoids, compared to organoids alone.

14 Jan 2020

Boehringer Ingelheim and Enleofen partner to develop anti-IL-11 therapies for multiple fibrotic disorders

Boehringer Ingelheim and Enleofen Bio Pte. Ltd. announced today the acquisition of worldwide exclusive rights to Enleofen’s preclinical interleukin-11 (IL-11) platform by Boehringer Ingelheim to develop first-in-class therapies across a broad range of fibro-inflammatory diseases.

From Boehringer Ingelheim International GmbH 14 Jan 2020

How SpatialOMx is Delivering New Insights into Disease Research

An interview with Shannon Cornett Ph.D, discussing the use of MALDI-guided spatial molecular analysis for biomarker discovery.

From Bruker Daltonics 14 Jan 2020

Increased Vegetable Intake Fails to Slow Prostate Cancer Progression, Study Finds

Researchers in the United States have conducted a study investigating whether a telephone-based interventional program encouraging an increased intake of vegetables would slow disease progression among patients with early-stage prostate cancer.

14 Jan 2020

Researchers provide first robust cell culture model for hepatitis E virus

Even though hepatitis E causes over three million infections and about 70,000 deaths each year, the virus has been little studied as yet.

13 Jan 2020

Prenatal exposure to flame retardants may increase risk of reading problems

A new study from researchers at Columbia University Vagelos College of Physicians and Surgeons suggests that prenatal exposure to flame retardants may increase the risk of reading problems.

12 Jan 2020

A class of antibiotics could be potential treatment for frontotemporal dementia

Researchers at the University of Kentucky's College of Medicine have found that a class of antibiotics called aminoglycosides could be a promising treatment for frontotemporal dementia.

10 Jan 2020

LBIC acquires MILabs' new diagnostic X-Ray CT system to extend its preclinical imaging capabilities

The Bioimaging Center of Lund University is a leading trans-faculty research center that houses a wide range of advanced preclinical and clinical imaging equipment. To further extend its preclinical imaging capabilities, LBIC recently acquired a MILabs uCT diagnostic X-ray CT system.

10 Jan 2020

Preclinical News and Research

Human organ chips for better drug development

Improving drug testing with comprehensive 'Organ Chip' platform

Medtronic: RCT demonstrates profound back pain relief with DTM therapy

Robotic heart to replace human transplants on the horizon

A microdose lithium formulation could halt signs of Alzheimer's pathology

Injecting nanoparticles into the bloodstream to reduce brain swelling after traumatic brain injury

Study: Non-medical cannabis use is more common in adults suffering from pain

FDA-approved medication for opioid addiction is increasing except in the youngest group

Novel drug inhibits liver damage, obesity and glucose intolerance in mice fed with high-fat diet

Research collaboration reveals potential treatment option for incurable blood cancers

Essential tremor caused by overactive brain waves

Erythropoietin treatment may not provide neuroprotection for preemies

Study shows superior functionality of Duodenum Intestine-Chip populated with organoids

Boehringer Ingelheim and Enleofen partner to develop anti-IL-11 therapies for multiple fibrotic disorders

How SpatialOMx is Delivering New Insights into Disease Research

Increased Vegetable Intake Fails to Slow Prostate Cancer Progression, Study Finds

Researchers provide first robust cell culture model for hepatitis E virus

Prenatal exposure to flame retardants may increase risk of reading problems

A class of antibiotics could be potential treatment for frontotemporal dementia

LBIC acquires MILabs' new diagnostic X-Ray CT system to extend its preclinical imaging capabilities

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