Genetic News and Research

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Tarceva shown to extend survival in advanced non-small cell lung cancer when used after initial chemo

OSI Pharmaceuticals, Inc. has announced further results from the Phase III SATURN study showing that Tarceva® (erlotinib) extended the survival of patients with advanced non-small cell lung cancer (NSCLC) when used as single agent, maintenance therapy in patients who did not progress following first-line treatment with platinum-based chemotherapy.

2 Aug 2009

Gene therapy for retinitis pigmentosa

An international team of scientists and clinicians from the United States and Saudi Arabia are working to develop gene therapy for treating a rare, hereditary retinal disease.

31 Jul 2009

Discovery of genetic link to age-related cataracts

Bing-Cheng Wang, Ph.D., Case Western Reserve University School of Medicine professor of pharmacology and senior staff scientist at MetroHealth Medical Center, and Sudha K. Iyengar, Ph.D. professor of genetic and molecular epidemiology at Case Western Reserve University School of Medicine, have discovered the first gene associated with the formation of age-related cataracts, a leading causes of blindness.

31 Jul 2009

Dynamic, 3D pattern formation within protein-based gel

Modern regenerative medicine is on the lookout for implantable materials that can change as the surrounding tissue does, and two Stanford University researchers have made some new gel materials that do just that. Karin Straley and Professor Sarah Heilshorn have developed a method for preparing protein-based implant materials that can evolve with the changing needs of the host biological system. Not only can their new materials change in different ways at different times, they can do so at different places within the implant materials.

31 Jul 2009

Scientists re-engineer human enzyme to become resistant to harmful agents such as chemotherapy

Scientists from the Université de Montréal and McGill University have re-engineered a human enzyme, a protein that accelerates chemical reactions within the human body, to become highly resistant to harmful agents such as chemotherapy, according to a new study published in The Journal of Biological Chemistry.

28 Jul 2009

Study of pulmonary hypertension treatment in sickle cell patients stopped by NHLBI

The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health has stopped a clinical trial testing a drug treatment for pulmonary hypertension in adults with sickle cell disease nearly one year early due to safety concerns.

28 Jul 2009

Analysis suggests human development is set by ongoing interplay of parent and offspring genes

An analysis of rare genetic disorders in which children lack some genes from one parent suggests that maternal and paternal genes engage in a subtle tug-of-war well into childhood, and possibly as late as the onset of puberty.

28 Jul 2009

Study finds few patients die from prostate cancer within 15 years of radical prostatectomy

Investigators at Memorial Sloan-Kettering Cancer Center (MSKCC), along with collaborating teams at the Cleveland Clinic and the University of Michigan, have completed the first large- scale, multi-institutional study of prostate cancer death after standard treatment to remove the prostate since PSA screening has become widely used as a method to screen for the disease.

28 Jul 2009

Gene expression patterns in cancer could aid early screening and prevention

Distinctive patterns of genes turned off - or left on - in healthy versus cancerous cells could enable early screening for many common cancers and maybe help avoid them, Medical College of Georgia scientists say.

28 Jul 2009

Current diagnostic tests for ovarian cancer woefully ineffective

A new study finds that in order to make a significant dent in the mortality rate for the deadly cancer, the tests would have to be able to detect tumors of less than 1 cm in diameter, or about 200-times smaller in mass than those currently used to assess potential new tests. Still, if that hurdle can be overcome, there is good reason to believe that testing could make a big difference: The window of opportunity for treating these clinically undetectable cancers before they become life threatening is surprisingly long: about four years.

28 Jul 2009

Cost effectiveness study looks at potential value of new genetic test for guiding chemotherapy treatment

For the 29,000 patients in the United States with metastatic colorectal cancer, chemotherapy with irinotecan is a standard treatment that has been shown to improve survival. But for more than one in 10 of these patients, a variation in their DNA means that this treatment could result in a severe reduction in their white blood cell count, leading to a high risk of bacterial infection and possible subsequent death.

27 Jul 2009

Research builds on previous Par-4 study that produced cancer-resistant mouse

Human cells are able to secrete a cancer-killing protein, scientists at the University of Kentucky's Markey Cancer Center have found.

26 Jul 2009

Protein produced by gene fusion that may also be targeted for new prostate cancer therapies

Researchers from NewYork-Presbyterian Hospital/Weill Cornell Medical Center have discovered a new gene fusion that is highly expressed in a subset of prostate cancers.

24 Jul 2009

FDA authorizes emergency use of another test for H1N1 flu virus

The U.S. Food and Drug Administration today announced it has issued an Emergency Use Authorization (EUA) for a another diagnostic test for the 2009 H1N1 influenza virus, whose spread has caused the virus to be characterized as a pandemic by the World Health Organization.

24 Jul 2009

Parabon NanoLabs awarded research grant to develop novel cancer therapeutics

Parabon NanoLabs, a leading designer and manufacturer of breakthrough products at the nanoscale, announced today its award of a National Science Foundation (NSF) Small Business Innovative Research (SBIR) grant.

21 Jul 2009

Miglustat shows promise for cystic fibrosis

Miglustat is a drug currently under phase 2 clinical trials on patients suffering from cystic fibrosis (1). Its potential for treating the disease was discovered in 2006 thanks to the work of Frédéric Becq's team at the Institute of Cell Physiology and Biology (CNRS/Université de Poitiers), funded by the associations Vaincre la Mucoviscidose, MucoVie66, La Pierre Le Bigaut and ABCF2.

21 Jul 2009

Discovery of gene linked to follicular lymphoma

California and Arizona researchers have identified a gene variant that carries nearly twice the risk of developing an increasingly common type of blood cancer, according to a study published online today by the science journal Nature Genetics.

20 Jul 2009

Scientists develop process for 'surgical' genetic changes

Research led by scientists at Iowa State University's Plant Sciences Institute has resulted in a process that will make genetic changes in plant genes much more efficient, practical and safe.

20 Jul 2009

Gene variants associated with survival advantage in African Americans with HIV

From the start of the HIV epidemic, it appeared that some of the people who were infected with the virus were able to ward off the fatal effects of the disease longer than others.

20 Jul 2009

New understanding on mechanisms of DNA replication and transcription

By manipulating individual atoms in DNA and forming unique molecules, a Georgia State University researcher hopes to open new avenues in research towards better understanding the mechanisms of DNA replication and transcription, and perhaps leading to new treatments for diseases.

19 Jul 2009