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Study examines how cells exploit gene sequences to cope with toxic stress

Toxic chemicals wreak havoc on cells, damaging DNA and other critical molecules. A new study from researchers at MIT and the University at Albany reveals how a molecular emergency-response system shifts the cell into damage-control mode and helps it survive such attacks by rapidly producing proteins that counteract the harm.

4 Jul 2012

Researchers identify mechanism responsible for inhibition of AMPK activity in the hypothalamus

In the complex chain of molecular events that underlie eating behaviors and body weight, the AMP-activated protein kinase (AMPK) enzyme has proven to be a critical link.

4 Jul 2012

Study tracks changes in spending, prices, and use of health care services by children

Spending on health care for children grew faster than spending for adults between 2007 and 2010 due to increasing prices for all categories of goods and services, finds a new report from the Health Care Cost Institute (HCCI).

2 Jul 2012

Stress during pregnancy increases children's risk for abnormal health conditions at birth

Expectant mothers who dealt with the strain of a hurricane or major tropical storm passing nearby during their pregnancy had children who were at elevated risk for abnormal health conditions at birth, according to a study led by a Princeton University researcher that offers new insights into the effects of stress on pregnancy.

30 Jun 2012

Ovarian grafts can produce hormones for more than 7 years

Transplanting previously frozen ovarian tissue back into female cancer survivors can lead to long-term hormonal function and preservation of fertility, according to a new study by Samuel Kim from the University of Kansas Medical Center in the US. His work-, which shows that hormonal function was restored in five women 12-20 weeks after transplantation, and in one case lasted for more than seven years, appears online in the Journal of Assisted Reproduction and Genetics-, published by Springer.

29 Jun 2012

Prenatal exposure to PCBs impacts reproductive function in offspring

Prenatal exposure to the environmental contaminants polychlorinated biphenyls, or PCBs, causes long-term changes to the developing brain that have adverse effects on reproductive function later in life, a new study finds. Results will be presented Saturday at The Endocrine Society's 94th Annual Meeting in Houston.

28 Jun 2012

Study suggests adverse role for BclI polymorphism in obesity and insulin resistance

A large study in people at risk of diabetes has found a direct association between the presence of a small genetic alteration in a hormone receptor and increased body fat and insulin resistance. The results, to be presented Tuesday at The Endocrine Society's 94th Annual Meeting in Houston, suggest an adverse role for a previously described genetic variant, the BclI polymorphism.

28 Jun 2012

Molecular determinant of implantation success uncovered

A signaling sequence initiated by the embryo and hinging on the epithelial Na+ channel leads to successful implantation, researchers report in Nature Medicine.

26 Jun 2012

Marker to identify patients who have difficulties in maintaining body weight

A pre-diet measurement of two hormones related to weight regulation can help predict which dieters will be more likely to maintain their weight loss and who will not, according to a new study. The results will be presented Sunday at The Endocrine Society's 94th Annual Meeting in Houston.

26 Jun 2012

Male hormonal contraceptives applied daily to the skin reduce sperm production

Male hormonal contraceptives applied daily to the skin reduce sperm production, finds a new study to be presented Sunday at The Endocrine Society's 94th Annual Meeting in Houston.

26 Jun 2012

Positive results from Lexicon’s LX4211 Phase 2b trial on type 2 diabetes

Lexicon Pharmaceuticals, Inc., announced today that LX4211, an investigational, oral, dual inhibitor of sodium glucose transporters 1 and 2 (SGLT1 and SGLT2), showed substantial, dose-dependent, statistically-significant reductions in hemoglobin A1c (HbA1c) in a Phase 2b trial in patients diagnosed with poorly-controlled type 2 diabetes who were concurrently treated with metformin, an established diabetes therapy.

25 Jun 2012

Low DHEA-S levels may increase risk of heart and blood-vessel disease in elderly men

Low levels of a naturally occurring steroid are associated with an increased risk of heart and blood-vessel disease in elderly men, a new study finds. The results will be presented Saturday at The Endocrine Society's 94th Annual Meeting in Houston.

25 Jun 2012

Drop in testosterone levels more likely to result from man's behavioral and health changes

A new study finds that a drop in testosterone levels over time is more likely to result from a man's behavioral and health changes than by aging. The study results will be presented Monday at The Endocrine Society's 94th Annual Meeting in Houston.

25 Jun 2012

Oxytocin hormone plays an important role in Williams syndrome

The hormone oxytocin - often referred to as the "trust" hormone or "love hormone" for its role in stimulating emotional responses - plays an important role in Williams syndrome (WS), according to a study published June 12, 2012, in PLoS One.

23 Jun 2012

Review describes new classes of drugs that target androgens in novel ways

Prostate cancer cells require androgens including testosterone to grow. A recent review in the British Journal of Urology International describes new classes of drugs that target androgens in novel ways, providing alternatives to the traditional methods that frequently carry high side effects.

21 Jun 2012

Social-class discrimination can contribute to physiologic changes associated with poorer health

Discrimination felt by teenagers based on their social class background can contribute to physiologic changes associated with poorer health, according to a new study led by a University of Wisconsin-Madison researcher.

16 Jun 2012

Exercise-related hormones do not play an influential role in building muscle

New research from scientists at McMaster University reveals exercise-related testosterone and growth hormone do not play an influential role in building muscle after weightlifting, despite conventional wisdom suggesting otherwise.

15 Jun 2012

Study: Quirky fruit fly gene can help develop new weapons against cancer

Loyola University Chicago researchers are taking advantage of a quirk in the evolution of fruit fly genes to help develop new weapons against cancer.

15 Jun 2012

Compounds related to curcumin receive U.S. patent

A U.S patent issued today to the University of Rochester and two other entities for the use of compounds related to a popular spice in the fight against cancer, acne, baldness, and other medical conditions.

13 Jun 2012

Long-lasting weekly fertility injections work as well as daily

New long-lasting weekly injections of fertility hormones are as safe and effective as standard daily injections, according to Cochrane researchers. The researchers compared weekly and daily hormone injections in a Cochrane systematic review and found no difference in pregnancies or serious side effects between the two regimens.

13 Jun 2012

Hormones News and Research

Study examines how cells exploit gene sequences to cope with toxic stress

Researchers identify mechanism responsible for inhibition of AMPK activity in the hypothalamus

Study tracks changes in spending, prices, and use of health care services by children

Stress during pregnancy increases children's risk for abnormal health conditions at birth

Ovarian grafts can produce hormones for more than 7 years

Prenatal exposure to PCBs impacts reproductive function in offspring

Study suggests adverse role for BclI polymorphism in obesity and insulin resistance

Molecular determinant of implantation success uncovered

Marker to identify patients who have difficulties in maintaining body weight

Male hormonal contraceptives applied daily to the skin reduce sperm production

Positive results from Lexicon’s LX4211 Phase 2b trial on type 2 diabetes

Low DHEA-S levels may increase risk of heart and blood-vessel disease in elderly men

Drop in testosterone levels more likely to result from man's behavioral and health changes

Oxytocin hormone plays an important role in Williams syndrome

Review describes new classes of drugs that target androgens in novel ways

Social-class discrimination can contribute to physiologic changes associated with poorer health

Exercise-related hormones do not play an influential role in building muscle

Study: Quirky fruit fly gene can help develop new weapons against cancer

Compounds related to curcumin receive U.S. patent

Long-lasting weekly fertility injections work as well as daily

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