Preclinical News and Research

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Integral Molecular announces panel of P2X7 antibodies for autoimmune disorders

Integral Molecular, the leader in discovering antibodies against multipass membrane proteins, announces lead monoclonal antibodies (MAbs) against P2X7, a structurally complex ion channel that is the target for autoimmune disorders including atopic dermatitis and glomerulonephritis.

10 Jan 2020

Non-fibrillating form of human insulin could improve treatment for diabetes patients

In a promising discovery that could improve the clinical delivery of insulin for people living with diabetes, scientists have developed a non-fibrillating form of human insulin.

9 Jan 2020

Research may open new avenues for big advance in neuroprostheses

Once you learn a skill like tying your sneakers, you can perform it consistently over the years. This suggests the neural activity in the brain associated with the skill remains stable over time.

9 Jan 2020

Researchers one step closer to developing vaccines that protect infants against infections

A new Penn Medicine study puts researchers within closer reach of vaccines that can protect infants against infections by overcoming a mother's antibodies, which are known to shut down immune defenses initiated by conventional vaccines.

9 Jan 2020

SVC112 molecule acts specifically against head and neck cancer stem cells

The red, tube-shaped flowers of the firecracker bush (Bouvardia ternifolia), native to Mexico and the American Southwest, attract hummingbirds.

8 Jan 2020

Study may provide novel targetable mechanisms of therapeutic resistance to anti-VEGF therapies

To establish a molecular signature of this resistance in ovarian cancer, the authors developed preclinical tumor models of adaptive resistance to chronic anti-VEGF treatment.

8 Jan 2020

Airway Therapeutics receives funding to advance BPD treatment

Airway Therapeutics, Inc., a biopharmaceutical company developing a new class of biologics to break the injury cycle of inflammation for patients with respiratory and inflammatory diseases, announced today the closing of a $15.5 million oversubscribed Series C financing round.

8 Jan 2020

Mayo Clinic researchers seek radical new approach to treat cocaine addition

In a radical new approach to treat cocaine addition, researchers at the Mayo Clinic are seeking approval for first-in-human studies of a single-dose gene therapy.

7 Jan 2020

Dana-Farber Cancer Institute to create Chen-Huang Center for EGFR Mutant Lung Cancers

Dana-Farber Cancer Institute will create the Chen-Huang Center for EGFR (epidermal growth factor receptor) Mutant Lung Cancers to stimulate research, promote clinical trials, and strengthen the Institute's capabilities for studying and treating lung cancer.

7 Jan 2020

Discovery could pave way for new breast cancer drugs

Eric Prossnitz, PhD, hopes to help many of the 12% of American women who are projected to be diagnosed with breast cancer in their lifetimes.

7 Jan 2020

New clinical study to test retinal screening processes for early detection of Alzheimer's disease

The University of Rhode Island, in collaboration with BayCare Health System in Florida and The Memory and Aging Program at Butler Hospital, an affiliate of The Warren Alpert Medical School of Brown University, is launching a clinical trial of retinal screening processes that could help clinicians detect Alzheimer's disease possibly two or more decades before patients develop life-altering clinical symptoms.

6 Jan 2020

Researchers show new potential path to improve bone-repair procedures

Researchers are moving closer to a new approach for improving spinal fusion procedures and repairing broken or defective bones that avoids an over-production of bone that commonly occurs in current treatments.

3 Jan 2020

New radiotracer can provide insights into how the heart recovers after myocardial infarction

Insights into how the heart recovers after myocardial infarction (heart attack) can be obtained with a new radiotracer that targets fibroblast activity prior to it causing permanent damage.

2 Jan 2020

Obj-SCD predicts future amyloid accumulation and neurodegeneration

Writing in the December 30, 2019 online issue of Neurology, researchers at University of California San Diego School of Medicine and Veterans Affairs San Diego Healthcare System report that accumulating amyloid -- an abnormal protein linked to neurodegenerative conditions such as Alzheimer's disease -- occurred faster among persons deemed to have "objectively-defined subtle cognitive difficulties" (Obj-SCD) than among persons considered to be "cognitively normal."

31 Dec 2019

Novela Neurotech’s “smart” neural interface displayed at Creative Destruction Lab

Novela Neurotech, a MedTech company developing AI-powered wireless, "smart" neural interface systems, joins Canada's Creative Destruction Lab to further fine-tune its health technologies to the needs of patients with difficult neurological disorders.

31 Dec 2019

New combination of antibodies leads to more effective tumor destruction

The simultaneous use of antibodies based on two differing mechanisms of action leads to a more effective destruction of tumors.

30 Dec 2019

Scientists discover potential drug compounds that target common type of liver cancer

Scientists from the Cancer Science Institute of Singapore at the National University of Singapore, and the Agency for Science, Technology and Research (A*STAR)'s Genome Institute of Singapore have discovered four potential drug compounds that target hepatocellular carcinoma, the most common type of liver cancer.

30 Dec 2019

Preclinical News and Research

Integral Molecular announces panel of P2X7 antibodies for autoimmune disorders

Non-fibrillating form of human insulin could improve treatment for diabetes patients

Research may open new avenues for big advance in neuroprostheses

Researchers one step closer to developing vaccines that protect infants against infections

SVC112 molecule acts specifically against head and neck cancer stem cells

Study may provide novel targetable mechanisms of therapeutic resistance to anti-VEGF therapies

Airway Therapeutics receives funding to advance BPD treatment

Mayo Clinic researchers seek radical new approach to treat cocaine addition

Dana-Farber Cancer Institute to create Chen-Huang Center for EGFR Mutant Lung Cancers

Discovery could pave way for new breast cancer drugs

New clinical study to test retinal screening processes for early detection of Alzheimer's disease

Researchers show new potential path to improve bone-repair procedures

New radiotracer can provide insights into how the heart recovers after myocardial infarction

Obj-SCD predicts future amyloid accumulation and neurodegeneration

Novela Neurotech’s “smart” neural interface displayed at Creative Destruction Lab

New combination of antibodies leads to more effective tumor destruction

Scientists discover potential drug compounds that target common type of liver cancer

Lab-grown brain organoids may hold the answers to personalized treatments for glioblastomas

Synthetic mRNA nanoparticles restore tumor suppressor gene, make cancer cells susceptible to drugs

New technique provides real-time images of biomolecules in living cells

Event guide: 4th LNP Formulation & Process Development Summit eBook

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Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

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Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics