Genetic News and Research

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Pathway opens up cure for Fanconi anemia

In patients with Fanconi anaemia (FA) one of the DNA repair mechanisms that normally protects us against cancer no longer works adequately. Dutch researcher Najim Ameziane set out to find the genes responsible for this defect.

14 May 2009

Research shows how cocaine regulates gene expression in a crucial reward region

The study, published by Cell Press in the May 14th issue of the journal Neuron, provides exciting insight into the molecular pathways regulated by cocaine and may lead to new strategies for battling drug addiction.

13 May 2009

Cognition already seriously impaired in first episode of schizophrenia

Significant and widespread cognitive problems appear to exist in schizophrenia in its earliest phase, making it very hard for people with the disorder to work, study or be social, according to a new study published by the American Psychological Association.

13 May 2009

Clues about how blood forms could yield new strategies for treating blood diseases

Biologists have long wondered why the embryonic heart begins beating so early, before the tissues actually need to be infused with blood.

13 May 2009

Promising new targets for medications to treat cocaine addiction

Repeated use of addictive drugs such as cocaine causes long-lasting changes in parts of the brain involved in motivation and reward, among others, yet the precise mechanisms by which these changes are maintained are poorly understood.

13 May 2009

University of Liverpool awarded £2.2 million for genomics hub

The University of Liverpool has been awarded £2.2 million to establish a high-throughput genomic analysis hub for the North of England.

13 May 2009

Diet rich in nuts and olive oil protects against age-related macular degeneration

New research has found that a diet which is low in trans fats and regularly includes nuts, olive oil and other foods containing omega-three fatty acids appears to offer some protection from the eye disease age-related macular degeneration (AMD).

13 May 2009

Bacteria create aquatic superbugs in waste treatment plants

For bacteria in wastewater treatment plants, the stars align perfectly to create a hedonistic mating ground for antibiotic-resistant superbugs eventually discharged into streams and lakes.

13 May 2009

Fat capsules carry markers for deadly prostate cancer

Tiny bubbles of fat in urine hold molecules that could predict whether prostate cancer is aggressive, according to research published in the British Journal of Cancer today (Wednesday).

12 May 2009

American Civil Liberties Union challenges breast cancer gene patents

The American Civil Liberties Union and the Public Patent Foundation at Benjamin N. Cardozo School of Law (PUBPAT) filed a lawsuit today charging that patents on two human genes associated with breast and ovarian cancer stifle research that could lead to cures and limit women's options regarding their medical care.

12 May 2009

Negative mood-related drinking may mean vulnerability for major depression and alcohol dependence

Major depression (MD) and alcohol dependence (AD) co-occur in individuals and within families at higher rates than expected by chance. This study looked at how mood-related drinking motives may explain the overlapping familial risk for MD and AD. Findings suggest that individuals with strong mood-related drinking motives, especially those based on negative feelings, may be vulnerable to developing both MD and AD.

12 May 2009

Research suggests potential new treatment for anxiety disorders and depression

New research on a brain chemical involved in development sheds light on why some individuals may be predisposed to anxiety. It also strengthens understanding of cellular processes that may be common to anxiety and depression, and suggests how lifestyle changes may help overcome both

12 May 2009

In retinal disease, sight may depend on second sites

If two people have the same genetic disease, why would one person go blind in childhood but the other later in life or not at all? For a group of genetic diseases - so-called ciliary diseases that include Bardet-Biedl syndrome, Meckel-Gruber syndrome, and Joubert syndrome - the answer lies in one gene that is already linked to two of these diseases and also seems to increase the risk of progressive blindness in patients with other ciliary diseases. The findings are published online this week at Nature Genetics.

12 May 2009

Omega-three fatty acid rich foods lower risk for eye disease

Regularly eating fish, nuts, olive oil and other foods containing omega-three fatty acids and avoiding trans fats appears to be associated with a lower risk for the eye disease age-related macular degeneration, according to two reports in the May issue of Archives of Ophthalmology.

12 May 2009

Children who suffer traumatic brain injuries experience lasting or late-appearing neuropsychological problems

In one study, a team of psychologists used a longitudinal approach to gain a better idea of what to expect after traumatic brain injury (TBI). The researchers found that severe TBI can cause many lasting problems with day-to-day functioning.

12 May 2009

Discovery of genetic cause of luminal-type tumors

The discovery of tumor-suppressor genes has been key to unlocking the molecular and cellular mechanisms leading to uncontrolled cell proliferation - the hallmark of cancer. Often, these genes will work in concert with others in a complex biochemical system that keeps our cells growing and dividing, disease free.

12 May 2009

Smoking makes it harder for brain blood flow to recover from long-term heavy drinking

Alcohol-use disorders (AUDs) can damage the brain, particularly the frontal and parietal cortices, although this damage is at least partially reversible with sustained abstinence from alcohol. Chronic smoking is extremely common among individuals with AUDs.

12 May 2009

New genetic clues to treatment of hypertension

An international research team has identified a number of unsuspected genetic variants associated with systolic blood pressure (SBP), diastolic blood pressure (DBP), and hypertension (high blood pressure), suggesting potential avenues of investigation for the prevention or treatment of hypertension.

12 May 2009

Discovery of eight previously unknown genes that affect blood pressure

Eight previously unknown genes that affect blood pressure were recently identified in a comprehensive international study comprising 34,433 Europeans. The findings of the study, in which Uppsala University researchers participated, are being presented in the Web edition of Nature Genetics.

11 May 2009

Muscular dystrophy diagnosis delayed in boys

Boys show signs of Duchenne Muscular Dystrophy (DMD) for 2 ½ years before they obtain a diagnosis and disease-specific treatment, about the same length of delay children have endured for the past 20 years despite advances in genetic testing and treatment.

11 May 2009