Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Scientists find new molecular biomarker for gastric cancer

Although immunotherapy is seen as a very promising treatment for cancer, currently only 20 to 30 percent of patients respond positively. Being able to identify the people most likely to benefit from the costly therapy is a Holy Grail for oncologists.

9 Aug 2018

New AI algorithm helps predict medication response in patients with complex mood disorder

Mood disorders like major depressive disorder and bipolar disorder are often complex and hard to diagnose, especially among youth when the illness is just evolving.

9 Aug 2018

Cancer cells release biological 'drones' to assist in the fight against immune system

Cancer cells are more than a lump of cells growing out of control; they participate in active combat with the immune system for their own survival. Being able to evade the immune system is a hallmark of cancer.

9 Aug 2018

Gene considered as tumor promoter may also halt development of cancer, shows study

A gene that has for decades been considered a tumor promoter, the PLK1 gene, can also perform the exact opposite function: halting the development of cancer.

9 Aug 2018

Physical activity can help reduce risk of heart disease in older adults

Adults in their early 60s, who spend less time sitting and more time engaged in light to vigorous physical activity, benefit with healthier levels of heart and vessel disease markers, according to new research in Journal of the American Heart Association, the Open Access Journal of the American Heart Association/American Stroke Association.

9 Aug 2018

Study identifies distinct genetic mutations in appendix cancer that may impact treatment

The rarity of appendix cancer, accounting for less than 1 percent of tumors that originate in the gastrointestinal tract, and the lack of scientific data for this disease means that current treatment guidelines recommend applying therapies to people with appendix cancer that are intended for those with colon cancer.

9 Aug 2018

Silencing of GULP1 gene expression plays important role in ovarian carcinogenesis

Johns Hopkins researchers in collaboration with Insilico Medicine, a biotechnology company based in Rockville Maryland, identify that silencing of the GULP1 gene expression by methylation plays an important role in ovarian carcinogenesis.

7 Aug 2018

New test method offers more reliable diagnosis of diabetes insipidus

When people produce excessive amounts of urine - more than three litres each day in adults is considered too much - doctors often find it difficult to establish a diagnosis under certain circumstances.

7 Aug 2018

Researchers study how herpesviruses contribute to increased oral inflammation

A $2 million grant from the National Institutes of Health will help University of Illinois at Chicago researchers study how herpesviruses, and their underlying molecular mechanisms, contribute to increased inflammation in oral diseases, like periodontitis

2 Aug 2018

Tumor suppressor gene PTEN may be potential Achilles heel for breast cancer cells

In an article published July 17, 2018 by Nature Communications, a highly collaborative team of researchers at the Medical University of South Carolina and Ohio State University report that normal breast cells can prevent successful radiation treatment of breast cancer due to dysregulation between tumor suppressors and oncogenes.

2 Aug 2018

Acetyl-L-carnitine chemical in blood connected to depression

A group of researchers from Stanford in collaboration with other universities have found that in humans a low level of acetyl-L-carnitine or L-acetyle carnitine in blood could be a predictor of the duration and severity of depression.

1 Aug 2018

Novartis' new drug combination receives positive CHMP opinion for treating stage III BRAF mutant melanoma

Novartis today announced the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted a positive opinion recommending approval of Tafinlar® in combination with Mekinist® for the adjuvant treatment of adult patients with stage III melanoma with a BRAF V600 mutation, following complete resection.

27 Jul 2018

Brain scan can help select the right Parkinson’s patients for clinical trials

From today forward, researchers and drug companies have a new tool in the search for better treatments for Parkinson’s – a brain scan that can be used to select the right people for clinical trials.

27 Jul 2018

Qualification of first Parkinson's biomarker represents major milestone in clinical trials

The biomarker is used to determine the presence of dopamine transport deficiency in the brain, and has been qualified as an enrichment biomarker for clinical trials targeting early stages of Parkinson's, soon after diagnosis

27 Jul 2018

Multi-center study results demonstrate best-in-class performance of Bladder EpiCheck urine test

Nucleix Ltd., a leading cancer detection and screening company, announced today that the multi-center European study results with its Bladder EpiCheck urine test for the detection of bladder cancer recurrence, were published in the European Urology Oncology journal.

26 Jul 2018

Study supports clinical role of biomarker test to rule out the need for CT scan in TBI patients

Banyan Biomarkers, Inc., a pioneer in developing biomarkers for traumatic brain injury (TBI), today announced the publication of the results for the ALERT-TBI study, an international, multicenter clinical trial utilizing the Banyan Brain Trauma Indicator.

26 Jul 2018

Immune cells may actually disrupt moisturizing glands and cause dry eye disease

Immune cells that normally rush in to protect the eyes from infection might actually be disrupting moisturizing glands and causing dry eye, a disease that afflicts more than 30 million people in the United States.

26 Jul 2018

How soon is soon enough to learn you have Alzheimer’s?

Jose Belardo of Lansing, Kan., spent most of his career in the U.S. Public Health Service. He worked on the front lines of disasters in such places as Haiti, Colombia, Nicaragua and the Dominican Republic. At home with his three kids and wife, Elaine, he’d always been unfailingly reliable, so when he forgot their wedding anniversary two years in a row, they both started to worry.

26 Jul 2018

New blood test helps patients with traumatic head injury to avoid costly CT scan

Research conducted at the Wayne State University School of Medicine has helped confirm the effectiveness of a blood biomarker that can indicate if patients with a head injury can avoid a costly CT scan because the blood test results indicate no traumatic brain injury

26 Jul 2018

New data shows that simple blood test accurately diagnoses Peripheral Artery Disease

Prevencio, Inc., announces the publication of data that demonstrates a simple new blood test accurately diagnoses significant Peripheral Artery Disease, a circulatory problem in which plaque-narrowed arteries reduce blood flow to a patient's limbs and kidneys.

25 Jul 2018

Biomarker News and Research

Further Reading

Scientists find new molecular biomarker for gastric cancer

New AI algorithm helps predict medication response in patients with complex mood disorder

Cancer cells release biological 'drones' to assist in the fight against immune system

Gene considered as tumor promoter may also halt development of cancer, shows study

Physical activity can help reduce risk of heart disease in older adults

Study identifies distinct genetic mutations in appendix cancer that may impact treatment

Silencing of GULP1 gene expression plays important role in ovarian carcinogenesis

New test method offers more reliable diagnosis of diabetes insipidus

Researchers study how herpesviruses contribute to increased oral inflammation

Tumor suppressor gene PTEN may be potential Achilles heel for breast cancer cells

Acetyl-L-carnitine chemical in blood connected to depression

Novartis' new drug combination receives positive CHMP opinion for treating stage III BRAF mutant melanoma

Brain scan can help select the right Parkinson’s patients for clinical trials

Qualification of first Parkinson's biomarker represents major milestone in clinical trials

Multi-center study results demonstrate best-in-class performance of Bladder EpiCheck urine test

Study supports clinical role of biomarker test to rule out the need for CT scan in TBI patients

Immune cells may actually disrupt moisturizing glands and cause dry eye disease

How soon is soon enough to learn you have Alzheimer’s?

New blood test helps patients with traumatic head injury to avoid costly CT scan

New data shows that simple blood test accurately diagnoses Peripheral Artery Disease

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