Preclinical News and Research

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Metformin shows benefits on aging and different diseases

Researchers at McMaster University have unlocked one of the secrets behind the many benefits of metformin.

9 Dec 2019

Small, thin metal mesh loaded with T cells shrinks tumors in ovarian cancer models

New findings published Dec. 9 in Nature Biomedical Engineering from scientists at Fred Hutchinson Cancer Research Center show for the first time that a piece of small, thin metal mesh loaded with cancer-fighting immune cells shrinks tumors in preclinical models of ovarian cancer.

9 Dec 2019

Study shows how a new combination approach helps overcome resistance to cancer immunotherapy

Cancer immunology drugs, which harness the body's immune system to better attack cancer cells, have significantly changed the face of cancer treatment. People with aggressive cancers are now living longer, healthier lives. Unfortunately, cancer immunology therapy only works in a subset of patients.

9 Dec 2019

Piglet study shows probiotics and prebiotics work differently in girls and boys

The team from the Universities of Bristol and Reading found that 28-day old piglets produced very different levels of immune cells, antibodies and other immune-associated molecules depending on their sex, contradicting previous evidence suggesting that the difference in immunity begins during puberty.

9 Dec 2019

Study may provide novel therapeutic approach for Huntington's, Parkinson's diseases

Insights from their study may provide a novel therapeutic approach for diseases such as Huntington's and Parkinson's.

8 Dec 2019

Common first-line treatment for cryptococcal meningitis in being compromised by drug resistance

A common first-line treatment approach for cryptococcal meningitis in low-income countries is being compromised by the emergence of drug resistance, new University of Liverpool research warns.

8 Dec 2019

Common treatment for cryptococcal meningitis compromised by emergence of drug resistance

A common first-line treatment approach for cryptococcal meningitis in low-income countries is being compromised by the emergence of drug resistance, new University of Liverpool research warns.

6 Dec 2019

Gabapentin – a drug for nerve pain could help patients with spinal injury finds study

A preclinical study with mice has shown that Gabapentin, a drug that is commonly used in nerve pain could be useful for patients with spinal cord injury. Use of the drug showed improvement in upper limb function among the mice models of spinal cord injury, wrote the researchers. The study titled, “Gabapentinoid treatment promotes corticospinal plasticity and regeneration following murine spinal cord injury,” was published this week in the latest issue of the Journal of Clinical Investigation.

4 Dec 2019

A major step toward preventing GvHD in patients receiving bone marrow transplants

A drug used for rheumatoid arthritis has moved a step closer to FDA approval for a desperately needed new use.

4 Dec 2019

Findings could lead to new approach to treating alcohol use disorder

A single infusion of ketamine, combined with outpatient behavioral therapy, helped alcohol-dependent individuals abstain from drinking for a few weeks after the treatment, researchers at Columbia University Vagelos College of Physicians and Surgeons and New York State Psychiatric Institute have found.

4 Dec 2019

LUNAC-led drug discovery project receives funding under Innovate UK’s Biomedical Catalyst program

LUNAC Therapeutics, a UK based drug discovery company focused on the identification and development of advanced anticoagulants with minimal bleeding risk, today announced that, along with the Medicines Discovery Catapult and the University of Leeds, it has been awarded £3.14M funding under Innovate UK’s Biomedical Catalyst program.

4 Dec 2019

Study identifies improved treatment option for neuroblastoma

Neuroblastoma is a rare form of malignant tumor, primarily affecting children under the age of six. A research team led by molecular pathologist Lukas Kenner from MedUni Vienna's Department of Pathology has now discovered, through genome sequencing, that the protein ALK and the cancer gene PIM1 are involved in the development of this tumor.

4 Dec 2019

“Tic-Tac-Toe” tackles Alzheimer’s disease

Drawing on multiple scientific disciplines, a new team is gearing up for a fresh onslaught on Alzheimer’s disease (AD), the extremely common age-related condition associated with loss of memory and disability.

3 Dec 2019

Using genomics to identify promising novel treatment for lymphatic filariasis

Using innovative RNA sequencing techniques, researchers at the University of Maryland School of Medicine Institute for Genome Sciences identified a promising novel treatment for lymphatic filariasis, a disabling parasitic disease that is difficult to treat.

3 Dec 2019

Roswell Park-led scientists identify new defense mechanism against prostate cancer

A research team led by a scientist at Roswell Park Comprehensive Cancer Center has identified the molecule LRIG1 as an important endogenous tumor suppressor in prostate cancer. Writing in the journal Nature Communications, the team documents their findings from preclinical studies showing that overexpression of the LRIG1 protein inhibits prostate cancer development, while reducing naturally occurring LRIG1 promotes prostate tumor development.

3 Dec 2019

Study: TBK1 protein promotes cancer development, suppresses immune response to the disease

Researchers at The University of Texas MD Anderson Cancer Center have found that a protein involved in immune response to microbes also can fuel cancer development and suppress immune response to the disease.

3 Dec 2019

Consortium launches ambitious project to transform the treatment of pain

In an effort to address the critical public health need for new, safer and more effective medicines to treat pain, a consortium based at the Laboratory of Systems Pharmacology at Harvard Medical School has launched an ambitious project titled STOP PAIN (Safe Therapeutic Options for Pain and Inflammation).

2 Dec 2019

State-of-the-art expert reviews provide insights into vitamin D research

Vitamin D is essential for human health. Although much is known about its important role in bone metabolism and in certain areas of non-skeletal health, there are many open questions and topics of debate.

27 Nov 2019

Oligomerix and Feinstein Institutes publish preclinical data of Alzheimer's disease treatment

Oligomerix, Inc., a privately held company pioneering the development of tau oligomer inhibitors for Alzheimer's disease and related neurodegenerative disorders, and the Feinstein Institutes for Medical Research announced today the publication of preclinical data demonstrating that an oral small molecule drug inhibits the formation of neurotoxic tau oligomers in an animal model of tau aggregation most relevant to AD.

26 Nov 2019

Extra virgin olive oil boosts brain power

Researchers from the Lewis Katz School of Medicine at Temple University have found that extra virgin olive oil (EVOO) could help boost brain power and help halt the progression of the effects of aging on the brain. The study was published in the latest issue of the journal Aging Cell, and it was titled, “Extra virgin olive oil improves synaptic activity, short‐term plasticity, memory, and neuropathology in a tauopathy model.”

26 Nov 2019

Preclinical News and Research

Metformin shows benefits on aging and different diseases

Small, thin metal mesh loaded with T cells shrinks tumors in ovarian cancer models

Study shows how a new combination approach helps overcome resistance to cancer immunotherapy

Piglet study shows probiotics and prebiotics work differently in girls and boys

Study may provide novel therapeutic approach for Huntington's, Parkinson's diseases

Common first-line treatment for cryptococcal meningitis in being compromised by drug resistance

Common treatment for cryptococcal meningitis compromised by emergence of drug resistance

Gabapentin – a drug for nerve pain could help patients with spinal injury finds study

A major step toward preventing GvHD in patients receiving bone marrow transplants

Findings could lead to new approach to treating alcohol use disorder

LUNAC-led drug discovery project receives funding under Innovate UK’s Biomedical Catalyst program

Study identifies improved treatment option for neuroblastoma

“Tic-Tac-Toe” tackles Alzheimer’s disease

Using genomics to identify promising novel treatment for lymphatic filariasis

Roswell Park-led scientists identify new defense mechanism against prostate cancer

Study: TBK1 protein promotes cancer development, suppresses immune response to the disease

Consortium launches ambitious project to transform the treatment of pain

State-of-the-art expert reviews provide insights into vitamin D research

Oligomerix and Feinstein Institutes publish preclinical data of Alzheimer's disease treatment

Extra virgin olive oil boosts brain power

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