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Factors associated with proteinuria identified

Characteristics associated with proteinuria - a predictor of decline in child kidney function - have been identified, according to a study appearing in the March 2009 issue of the Clinical Journal of the American Society Nephrology (CJASN).

20 Mar 2009

Epigenetic mark guides stem cells toward their destiny

Not all stem cells are completely blank slates. Some, known as adult stem cells, have already partially embraced their fates, and are capable of becoming only cells of a particular type of tissue.

20 Mar 2009

Compound is key coordinator of clock and metabolism

Our circadian clock, or biological timing system, governs our daily cycles of feeding, activity and sleep.

20 Mar 2009

Epigenetic mark guides stem cells toward their destiny

Not all stem cells are completely blank slates. Some, known as adult stem cells, have already partially embraced their fates and are capable of becoming only cells of a particular type of tissue. So how do these tissue-specific stem cells restrict their fate?

19 Mar 2009

Groundbreaking study into depression

Medical researchers from Sydney University's Brain Dynamics Centre have launched a world-first study that could lead to a dramatic improvement in how people are treated medically for depression.

19 Mar 2009

Understanding mental illness through gene-environment interactions

Biological Psychiatry, published by Elsevier, is very pleased to present a special section of its February 1st issue devoted to fundamental new insights into epigenetics, a field of research devoted to understanding how the environment can produce long-lasting or even heritable changes in gene function without altering the DNA sequence.

17 Mar 2009

Superbug complicates treatment of infections in cystic fibrosis

The unexpected behaviour of a family of "superbugs" called the Burkholderia cepacia complex (Bcc) could have implications for the treatment of cystic fibrosis (CF) patients.

17 Mar 2009

New tumor markers determine therapy intensity

Characteristic changes in the DNA of medulloblastoma, the most frequent malignant brain tumor in childhood, indicate precisely how aggressively the tumor will continue to spread and what the chances of disease relapse are.

17 Mar 2009

MRSA study suggests strategy shift needed to develop effective therapeutics

USA300-the major epidemic strain of methicillin-resistant Staphylococcus aureus (MRSA) causing severe infections in the United States during the past decade-inherits its destructiveness directly from a forefather strain of the bacterium called USA500 rather than randomly acquiring harmful genes from other MRSA strains.

17 Mar 2009

Lung cancer: Molecular scissors determine therapy effectiveness

In the past few years, a number of anti-cancer drugs have been developed which are directed selectively against specific key molecules of tumor cells.

17 Mar 2009

Hearing could hold key to unlocking schizophrenia mystery

Measuring brain waves in response to hearing a variety of tones appears to be a useful way to begin understanding the underlying genetic abnormalities associated with schizophrenia, says a study headed by researchers at Harvard-affiliated McLean Hospital.

17 Mar 2009

Engineering flu vaccines

A new computerized method of testing could help world health officials better identify flu vaccines that are effective against multiple strains of the disease.

17 Mar 2009

Search for blood pressure secrets reveals a surprising new syndrome

Yale researchers investigating the genetic causes of blood pressure variation have identified a previously undescribed syndrome associated with seizures, a lack of coordination, developmental delay and hearing loss.

16 Mar 2009

Cause of severe pediatric epilepsy disorder discovered

Researchers at the University of California, San Diego School of Medicine have discovered that convulsive seizures in a form of severe epilepsy are generated, not on the brain's surface as expected, but from within the memory-forming hippocampus.

16 Mar 2009

A biomarker test to diagnose or rule out Alzheimer's disease

A test capable of confirming or ruling out Alzheimer's disease has been validated and standardized by researchers at the University of Pennsylvania School of Medicine.

16 Mar 2009

FTO obesity gene associated with susceptibility to polycystic ovary syndrome

Researchers have shown that a gene implicated in the development of obesity is also associated with susceptibility to polycystic ovary syndrome (PCOS).

16 Mar 2009

Genetic links to high levels of HDL cholesterol

HDL cholesterol (HDL-C), or "good" cholesterol, carries excess cholesterol - that might otherwise block arteries - from blood vessels back to the liver for processing and elimination.

16 Mar 2009

Discovery of master switch that might prevent cancer cells from metastasizing

Researchers at the University of Pennsylvania School of Medicine have identified a master switch that might prevent cancer cells from metastasizing from a primary tumor to other organs.

16 Mar 2009

First treatment for muscular dystrophy a step closer

Genetic researchers at Children's National Medical Center and the National Center of Neurology and Psychiatry in Tokyo published the results of the first successful application of "multiple exon-skipping" to curb the devastating effects of Duchenne muscular dystrophy in an animal larger than a mouse.

16 Mar 2009

ATCC develops and isolates novel avian flu monoclonal antibodies

ATCC (American Type Culture Collection) researchers have developed a panel of novel monoclonal antibodies (mAbs) against avian influenza viruses. These antibodies could lead to a rapid diagnostic test for the infection, ATCC announced today. The organization has filed a patent covering the development of these novel antibodies.

16 Mar 2009