Protein C News and Research

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Antibody-drug conjugate effective, less toxic for stage 1 HER2+ breast cancer

A year of treatment with a medicine made of an antibody and chemotherapy drug has proven highly effective in preventing stage 1 HER2-positive breast cancer from recurring in patients, a team led by Dana-Farber Cancer Institute researchers has found.

28 Jun 2024

PFDN6 protein could be a new target for colorectal cancer treatment

Researchers have identified a protein called PFDN6 that may play a role in the development and spread of colorectal cancer (CRC).

27 Jun 2024

CHARMs: A new hope for prion disease therapy

Drug development is typically slow: the pipeline from basic research discoveries that provide the basis for a new drug to clinical trials to production of a widely available medicine can take decades.

27 Jun 2024

Dietary fiber intake reshapes tryptophan metabolism, promoting gut health and reducing disease risks

A recent study in Nature Microbiology reveals that increased dietary fiber intake directs microbial tryptophan metabolism, leading to health benefits such as improved gut mucosa integrity and reduced risk of metabolic disorders.

27 Jun 2024

Understanding the role of vaccination in mitigating long COVID brain fog

Since the outset of the COVID-19 pandemic, 10 to 30 per cent of the general population has experienced some form of virus-induced cognitive impairment, including trouble concentrating, brain fog or memory loss.

27 Jun 2024

MICROBIOMES4SOY: Harnessing microbiome innovations for sustainable food systems

MICROBIOMES4SOY responds to the urgent call on World Microbiome Day to transition to healthier, more environmentally friendly, plant-based diets.

27 Jun 2024

Discovery of nanoparticle-based drug delivery system could revolutionize schizophrenia treatment

Schizophrenia is a complicated mental health disorder accompanied by wide range of symptoms such as hallucinations, impaired cognitive ability, and disorganized speech or behavior.

27 Jun 2024

Cell division's hidden safety mechanism may influence cancer growth

Before a cell commits fully to the process of dividing itself into two new cells, it may ensure the appropriateness of its commitment by staying for many hours - sometimes more than a day - in a reversible intermediate state, according to a discovery by researchers at Weill Cornell Medicine. Their revelation of this fundamental feature of biology includes details of its mechanisms and dynamics, which may inform the development of future therapies targeting cancers and other diseases.

27 Jun 2024

Amorphous calcium phosphate drives aortic valve stiffening

The human body has sophisticated defenses against the deposition of calcium minerals that stiffen heart tissues, researchers at the University of Illinois Urbana-Champaign and collaborators at UCLA Health and the University of Texas at Austin found in a new study that provides the first detailed, step-by-step documentation of how calcification progresses.

27 Jun 2024

A unifying marker streamlines macrophage research across age and sex

Macrophages play a critical role in the immune system by fighting infections and aiding in tissue repair. Understanding how these cells are activated in different scenarios is important for developing new medical treatments. However, identifying and studying macrophage activation has been challenging due to the complex nature of these cells and their responses.

27 Jun 2024

Researchers identify key players in abnormal bone differentiation

A study conducted by researchers at Baylor College of Medicine and collaborating institutions reveals the molecular events leading to osteogenesis imperfecta type V, a form of brittle bone disease caused by a mutation in the gene IFITM5.

27 Jun 2024

MPA-CF3: A marine-derived compound disrupting COPZ1 to combat EV-A71

This study is spearheaded by researcher Wu Zhong (National Engineering Research Center for the Emergence Drugs, Beijing Institute of Pharmacology and Toxicology, Beijing) and Prof. Yong Qin (West China School of Pharmacy, Sichuan University).

26 Jun 2024

Plant-based meat substitutes show promise for heart health

Even though there is substantial variability in the contents and nutritional profiles of plant-based meat alternatives (PBMAs), the nutritional profiles tend to reflect a heart-healthy dietary pattern.

26 Jun 2024

Atogepant may decrease the risk of developing rebound headache in people with migraine

A drug used to prevent migraine may also be effective in people with migraine who experience rebound headaches, according to a new study published in the June 26, 2024, online issue of Neurology, the medical journal of the American Academy of Neurology.

26 Jun 2024

Adaptive therapy approach can reduce toxicity and drug resistance in ovarian cancer

Ovarian cancer, often diagnosed at an advanced stage, presents significant treatment challenges because patients tend to develop resistance to conventional therapies quickly.

26 Jun 2024

Current screening guidelines could miss prostate cancer in transgender women receiving estrogen

Transgender women are still at risk for prostate cancer. A new study led by Cedars-Sinai Cancer investigators, published in the peer-reviewed Journal of the American Medical Association, concludes that current screening guidelines could miss early-stage prostate cancer in transgender women on hormone therapy.

26 Jun 2024

CSF1R marker enables study of Macrophage Activation Mosaicism

Macrophages play a critical role in the immune system by fighting infections and aiding in tissue repair.

26 Jun 2024

Study finds women lost more of their body weight on average with semaglutide than men

Researchers performed a secondary analysis of the semaglutide treatment effect in people with obesity and heart failure with a preserved left ventricular ejection fraction program that included individuals with diabetes mellitus, stratified by biological sex.

26 Jun 2024

ELRIG UK and The Protein Society Partner to advance protein sciences in drug discovery

Partners to host joint conference on ‘Protein Sciences in Drug Discovery’ in Cambridge, UK from 18–19 November 2024.

From ELRIG (UK) Ltd. 26 Jun 2024

New drug tirzepatide significantly improves sleep apnea and weight loss

The effects of tirzepatide on adults with obesity and moderate-to-severe obstructive sleep apnea.

26 Jun 2024

Protein C News and Research

Antibody-drug conjugate effective, less toxic for stage 1 HER2+ breast cancer

PFDN6 protein could be a new target for colorectal cancer treatment

CHARMs: A new hope for prion disease therapy

Dietary fiber intake reshapes tryptophan metabolism, promoting gut health and reducing disease risks

Understanding the role of vaccination in mitigating long COVID brain fog

MICROBIOMES4SOY: Harnessing microbiome innovations for sustainable food systems

Discovery of nanoparticle-based drug delivery system could revolutionize schizophrenia treatment

Cell division's hidden safety mechanism may influence cancer growth

Amorphous calcium phosphate drives aortic valve stiffening

A unifying marker streamlines macrophage research across age and sex

Researchers identify key players in abnormal bone differentiation

MPA-CF3: A marine-derived compound disrupting COPZ1 to combat EV-A71

Plant-based meat substitutes show promise for heart health

Atogepant may decrease the risk of developing rebound headache in people with migraine

Adaptive therapy approach can reduce toxicity and drug resistance in ovarian cancer

Current screening guidelines could miss prostate cancer in transgender women receiving estrogen

CSF1R marker enables study of Macrophage Activation Mosaicism

Study finds women lost more of their body weight on average with semaglutide than men

ELRIG UK and The Protein Society Partner to advance protein sciences in drug discovery

New drug tirzepatide significantly improves sleep apnea and weight loss

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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