Protein C News and Research

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Researchers discover substance that reinforces brain's self-healing functions after stroke

The only acute treatment for a stroke currently available is thrombolysis. This uses drugs that dissolve the blood clot responsible for the stroke, but it only reaches around 10 per cent of stroke patients in time to prevent lasting damage. For other patients, there are no other effective drugs that reduce the loss of brain function following a stroke.

17 Feb 2011

Metallic copper surfaces kill bacteria on contact

Metallic copper surfaces kill microbes on contact, decimating their populations, according to a paper in the February 2011 issue of the journal Applied and Environmental Microbiology. They do so literally in minutes, by causing massive membrane damage after about a minute's exposure, says the study's corresponding author, Gregor Grass of the University of Nebraska, Lincoln. This is the first study to demonstrate this mechanism of bacteriocide.

17 Feb 2011

Researchers develop new pneumococcal vaccine through novel discovery approach

Pneumococcus accounts for as much as 11 percent of mortality in young children worldwide. While successful vaccines like Prevnar exist, they are expensive and only work against specific pneumococcal strains, with the risk of becoming less effective as new strains emerge.

17 Feb 2011

ICR, AB SCIEX collaborate to standardize mass spectrometry-based tissue imaging

A key research area for The Institute of Cancer Research is investigating the spread of cancer in the human body in an effort to identify new and effective treatment strategies. To help advance this research, the ICR is collaborating with scientists at AB SCIEX, a global leader in life science analytical technologies, to standardize advanced methods of mass spectrometry-based tissue imaging.

17 Feb 2011

Spirulina Pacifica supplement may improve immune function, anemia in senior citizens

Cyanotech Corporation, world leader in microalgae-based health and nutrition supplements, announced today that researchers at the University of California at Davis have determined that microalgae-based Hawaiian Spirulina Pacifica may improve immune function and ameliorate anemia in persons over 50.

17 Feb 2011

Brain enzyme blocks accumulation of tau proteins, slows down progression of neural degeneration

Increasing puromycin-sensitive aminopeptidase, the most abundant brain peptidase in mammals, slowed the damaging accumulation of tau proteins that are toxic to nerve cells and eventually lead to the neurofibrillary tangles, a major pathological hallmark of Alzheimer's disease and other forms of dementia, according to a study published online in the journal, Human Molecular Genetics.

17 Feb 2011

Deactivation of CRTC1 protein increases lifespan

Substantial evidence suggests that lifespan is increased if an organism restricts its daily calorie intake, a spartan regime that some say works by just making life seem longer. A team of scientists from the Salk Institute of Biological Studies has discovered a molecular switch flipped by hunger that could not only make longevity more appetizing but identify drug targets for patients with aging-related diseases such as type II diabetes or cancer.

17 Feb 2011

Loss of 'twenty-four' gene makes it harder to wake up

Northwestern University scientists have discovered a new mechanism in the core gears of the circadian clock. They found the loss of a certain gene, dubbed "twenty-four," messes up the rhythm of the common fruit fly's sleep-wake cycle, making it harder for the flies to awaken.

17 Feb 2011

Molecular explanation to higher tendency for autism among males

George Washington University researcher, Dr. Valerie Hu, Professor of Biochemistry and Molecular Biology, and her team at the School of Medicine and Health Sciences, have found that male and female sex hormones regulate expression of an important gene in neuronal cell culture through a mechanism that could explain not only higher levels of testosterone observed in some individuals with autism, but also why males have a higher incidence of autism than females.

17 Feb 2011

Study sheds light on novel functions of certain PCSK enzymes

Recent studies conducted at the Institut de recherches cliniques de Montr-al on a group of PCSK enzymes could have a positive impact on health, from cholesterol to osteoporosis.

17 Feb 2011

Amicus to present additional positive data from Amigal Phase 2 extension study for Fabry disease

Amicus Therapeutics today announced that additional positive data from the ongoing Phase 2 extension study of its investigational drug Amigal™ (migalastat HCl) for Fabry disease will be presented at the Lysosomal Disease Network WORLD Symposium in Las Vegas, Nevada, February 16-18th, 2011.

17 Feb 2011

Vical announces issuance of U.S. Patent for cytomegalovirus vaccines

Vical Incorporated announced today the issuance of U.S. Patent No. 7,888,112 covering DNA vaccines for cytomegalovirus containing specific gene sequences and formulated with Vical's Vaxfectin adjuvant.

16 Feb 2011

Bone remodeling inflammatory protein linked to metastatic lung cancer development in mice with breast cancer

When doctors discover high concentrations of regulatory T cells in the tumors of breast cancer patients, the prognosis is often grim, though why exactly has long been unclear.

16 Feb 2011

Study explores role of proline containing peptides in inhibiting anti-apoptotic function of XIAP

Basic and translational research on cancer, and development of new cancer therapeutics, has focused on different aspects of cancer cellular function. One area of focus is the life and death of a cancer cell. Apoptosis, also known as programmed cell death, is a fundamental process of cells including cancer cells. The signal transduction pathways of apoptosis involve many different proteins and their interactions with each other.

16 Feb 2011

Deactivation of tau gene may help reverse memory loss in Alzheimer disease

Amyloid-beta and tau protein deposits in the brain are characteristic features of Alzheimer disease. The effect on the hippocampus, the area of the brain that plays a central role in learning and memory, is particularly severe. However, it appears that the toxic effect of tau protein is largely eliminated when the corresponding tau gene is switched off.

16 Feb 2011

Genetic proof for anti-cancer properties of antioxidants and autophagy inhibitors

Researchers from Jefferson's Kimmel Cancer Center have genetic evidence suggesting the antioxidant drugs currently used to treat lung disease, malaria and even the common cold can also help prevent and treat cancers because they fight against mitochondrial oxidative stress-a culprit in driving tumor growth.

16 Feb 2011

Research: Way heart responds to early beat is predictive of cardiac death

The way the heart responds to an early beat is predictive of cardiac death, especially for people with no conventional markers of cardiovascular disease, according to new research from Washington University School of Medicine in St. Louis.

16 Feb 2011

Pfenex enters strategic agreement with Boehringer Ingelheim for use of Expression Technology

Pfenex Inc., an industry leader in protein expression through the Pfenex Expression Technology platform and Boehringer Ingelheim International GmbH, a leading pharmaceutical company and global leader in biopharmaceutical contract development and manufacture, announced today that they have entered into a strategic agreement.

16 Feb 2011

Study: Overexpression of EZH2 protein promotes breast cancer progression

An essential protein for normal stem cell renewal also promotes the growth of breast cancer stem cells when it's overproduced in those cells, researchers at The University of Texas MD Anderson Cancer Center report in the February edition of Cancer Cell.

16 Feb 2011

Study: Heart rate turbulence is linked with increased risk of death from cardiovascular disease

Abnormal heart rate turbulence is associated with an increased risk of heart disease death in otherwise low-risk older individuals, according to a study funded by the National Heart, Lung, and Blood Institute, part of the National Institutes of Health.

15 Feb 2011

Protein C News and Research

Researchers discover substance that reinforces brain's self-healing functions after stroke

Metallic copper surfaces kill bacteria on contact

Researchers develop new pneumococcal vaccine through novel discovery approach

ICR, AB SCIEX collaborate to standardize mass spectrometry-based tissue imaging

Spirulina Pacifica supplement may improve immune function, anemia in senior citizens

Brain enzyme blocks accumulation of tau proteins, slows down progression of neural degeneration

Deactivation of CRTC1 protein increases lifespan

Loss of 'twenty-four' gene makes it harder to wake up

Molecular explanation to higher tendency for autism among males

Study sheds light on novel functions of certain PCSK enzymes

Amicus to present additional positive data from Amigal Phase 2 extension study for Fabry disease

Vical announces issuance of U.S. Patent for cytomegalovirus vaccines

Bone remodeling inflammatory protein linked to metastatic lung cancer development in mice with breast cancer

Study explores role of proline containing peptides in inhibiting anti-apoptotic function of XIAP

Deactivation of tau gene may help reverse memory loss in Alzheimer disease

Genetic proof for anti-cancer properties of antioxidants and autophagy inhibitors

Research: Way heart responds to early beat is predictive of cardiac death

Pfenex enters strategic agreement with Boehringer Ingelheim for use of Expression Technology

Study: Overexpression of EZH2 protein promotes breast cancer progression

Study: Heart rate turbulence is linked with increased risk of death from cardiovascular disease

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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