Infectious Diseases News and Research

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Bispecific antibodies neutralize SARS-CoV-2 and its variants

A new bioRxiv preprint study led by Joshua Tan from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, involves generating bispecific antibodies using a new method cross-linking the antibodies with adjacent spike proteins using dual N-terminal domain/receptor binding domain specificity.

7 Apr 2021

Michigan Medicine to kick off first national study on allergic reactions to COVID-19 vaccines

In a carefully controlled study, Michigan Medicine researchers will kick off the first national trial to study allergic reactions to the COVID-19 mRNA vaccines.

7 Apr 2021

NIH-funded clinical trial begins study of systemic allergic reactions to COVID-19 vaccines

A clinical trial is underway to determine whether people who are highly allergic or have a mast cell disorder are at increased risk for an immediate, systemic allergic reaction to the Moderna or Pfizer-BioNTech COVID-19 vaccines.

7 Apr 2021

World Health Day 2021: The humanitarians building a fairer world

In commemoration of World Health Day 2021, News-Medical interviews the International Medical Corps on how they are helping to achieve a fairer and healthier world.

7 Apr 2021

CoVIg-19 Plasma Alliance announces outcomes of NIH-funded Phase 3 ITAC clinical trial

The CoVIg-19 Plasma Alliance today announced that the Phase 3 Inpatient Treatment with Anti-Coronavirus Immunoglobulin (ITAC) clinical trial sponsored and funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), did not meet its endpoints. No serious safety signals were raised in the trial.

7 Apr 2021

Study suggests T-cells don't determine survival in severe COVID-19

In the study, which appeared on the pre-print server medRxiv, the team found that when the monkeys were reinfected, the T cell-depleted animals showed anamnestic immune responses, the enhanced reaction of the body's immune system to an antigen that is related to an antigen previously encountered.

6 Apr 2021

Vermont to give minority residents vaccine priority

States have tried with limited success to get covid vaccines to people of color, who have been disproportionately killed and hospitalized by the virus.

5 Apr 2021

Phase 1 clinical study of unique vaccine to protect against COVID-19 begins

A unique vaccine to protect against COVID-19 begins clinical testing Tuesday, 6 April, at the Walter Reed Army Institute of Research (WRAIR), part of the U.S. Army Medical Research and Development Command.

5 Apr 2021

FIND announces launch of a request for proposals to expand access to COVID-19 testing services

The Foundation for Innovative New Diagnostics (FIND) announced today the launch of a request for proposals (RFP) to accelerate the development, manufacturing, and market availability of accurate, affordable, quality-assured and easy-to-use SARS-CoV-2 self-tests for use in low- and middle-income countries (LMICs).

5 Apr 2021

Chemical inhibitor can reduce SARS-CoV-2's ability to infect host cell lines

James McKerrow, MD, PhD, dean of the Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego, has long studied neglected tropical diseases -- chronic and disabling parasitic infections that primarily affect poor and underserved communities in developing nations.

3 Apr 2021

Research offers new clues about the underlying mechanisms of itch

Eczema, or atopic dermatitis (AD), is sometimes called "the itch that rashes." Often, the itch begins before the rash appears, and, in many cases, the itchiness of the skin condition never really goes away.

3 Apr 2021

Study finds CD8+ T cell responses detect all major SARS-CoV-2 variants

There have been concerns that several SARS-CoV-2 variants have mutations that allow them to evade the immune system. A new study published in the Open Forum Infectious Diseases suggests otherwise. Led by Aaron AR Tobian of Johns Hopkins University School of Medicine, results showed that except for one from the B.1.351 variant, CD8+ T cells showed a broad response to all SARS-CoV-2 variants.

2 Apr 2021

Beating the pavement to vaccinate the underrepresented — and protect everyone

Leonor Garcia held her clipboard close to her chest and rapped on the car window with her knuckles. The driver was in one of dozens of cars lined up on a quiet stretch of road in Adelanto, California, a small city near the southwestern edge of the Mojave Desert.

2 Apr 2021

Study investigates the efficacy of COVID-19 vaccines over longer term

COVID-19 vaccines were designed to reduce the likelihood that infection by the SARS-CoV-2 virus would lead to severe outcomes, such as hospitalization and death. In that sense, all of the currently approved vaccines -- Moderna, Pfizer and Johnson & Johnson -- have proven comparably effective.

2 Apr 2021

Highly contagious SARS-CoV-2 variant was spreading for months before its discovery

A highly contagious SARS-CoV-2 variant was unknowingly spreading for months in the United States by October 2020, according to a new study from researchers with The University of Texas at Austin COVID-19 Modeling Consortium.

2 Apr 2021

Temperature difference in the upper and lower respiratory tract influences SARS-CoV-2 replication

A team of researchers from the Institute for Infectious Diseases (IFIK) at the University of Bern and the Federal Institute of Virology and Immunology (IVI) have assessed virus growth and activation of the cellular defense mechanisms in the respiratory tract.

1 Apr 2021

New Phase 1 clinical trial of investigational vaccine against B.1.351 SARS-CoV-2 variant begins

An investigational vaccine designed to protect against the B.1.351 SARS-CoV-2 variant has been administered as part of a new Phase 1 clinical trial evaluating the vaccine candidate's safety and immunogenicity in adult volunteers.

31 Mar 2021

Drinking flavanol-rich cocoa could protect from mental stress-induced cardiovascular events

Increased consumption of flavanols - a group of molecules occurring naturally in fruit and vegetables - could protect people from mental stress-induced cardiovascular events such as stroke, heart disease and thrombosis, according to new research.

31 Mar 2021

B.1.1.7 rapidly becoming the dominant SARS-CoV-2 variant in the United States

The faster-spreading B.1.1.7 variant of SARS-CoV-2 first detected in the United Kingdom, the coronavirus that causes COVID-19, is quickly on its way to becoming the dominant variant of the virus in the United States, according to a study from scientists at Scripps Research and the COVID-19 test maker Helix.

31 Mar 2021

Soft X-ray microscopy shows how viral pathogens penetrate human cells

How do viral pathogens succeed in penetrating human cells? Which cellular mechanisms do they use to multiply efficiently and, in doing so, how do they change the structure of their host cell? These questions are the focus of a pan-European research project called "Compact Cell-Imaging Device" (CoCID), in which Heidelberg scientists are playing a major role.

31 Mar 2021

Infectious Diseases News and Research

Bispecific antibodies neutralize SARS-CoV-2 and its variants

Michigan Medicine to kick off first national study on allergic reactions to COVID-19 vaccines

NIH-funded clinical trial begins study of systemic allergic reactions to COVID-19 vaccines

World Health Day 2021: The humanitarians building a fairer world

CoVIg-19 Plasma Alliance announces outcomes of NIH-funded Phase 3 ITAC clinical trial

Study suggests T-cells don't determine survival in severe COVID-19

Vermont to give minority residents vaccine priority

Phase 1 clinical study of unique vaccine to protect against COVID-19 begins

FIND announces launch of a request for proposals to expand access to COVID-19 testing services

Chemical inhibitor can reduce SARS-CoV-2's ability to infect host cell lines

Research offers new clues about the underlying mechanisms of itch

Study finds CD8+ T cell responses detect all major SARS-CoV-2 variants

Beating the pavement to vaccinate the underrepresented — and protect everyone

Study investigates the efficacy of COVID-19 vaccines over longer term

Highly contagious SARS-CoV-2 variant was spreading for months before its discovery

Temperature difference in the upper and lower respiratory tract influences SARS-CoV-2 replication

New Phase 1 clinical trial of investigational vaccine against B.1.351 SARS-CoV-2 variant begins

Drinking flavanol-rich cocoa could protect from mental stress-induced cardiovascular events

B.1.1.7 rapidly becoming the dominant SARS-CoV-2 variant in the United States

Soft X-ray microscopy shows how viral pathogens penetrate human cells

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