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Case studies for the role of in-process particle measurement to complement traditional API dissolution studies

Quantifying tablet disintegration profiles in situ and in real time enables scientists to reliably understand the breakage and dispersion mechanisms that govern API release rates. This essential process knowledge can support the prediction of in vivo drug release profiles during formulation development, and help identify the root cause of inconsistencies during release testing.

From Mettler-Toledo International Inc. 14 Mar 2017

Targeting cancer stem cells may be effective way to prevent spread of squamous cell carcinoma

Targeting cancer stem cells may be a more effective way to overcome cancer resistance and prevent the spread of squamous cell carcinoma — the most common head and neck cancer and the second-most common skin cancer, according to a new study by cancer researchers at the UCLA School of Dentistry.

10 Mar 2017

Drug could activate innate anti-tumor immunity to eradicate aggressive prostate cancer in mice

Cabozantinib, a drug already used to treat patients with certain types of thyroid or kidney cancer, was able to eradicate invasive prostate cancers in mice by causing tumor cells to secrete factors that entice neutrophils - the first-responders of the immune system - to infiltrate the tumor, where they triggered an immune response that led to tumor clearance.

9 Mar 2017

New approach could regenerate skull bone with better quality and no scar tissue

A team of researchers repaired a hole in a mouse's skull by regrowing "quality bone," a breakthrough that could drastically improve the care of people who suffer severe trauma to the skull or face.

8 Mar 2017

Study reports presence of structural changes in the brain during medication treatment for depression

A study led by Ravi Bansal, PhD, and Bradley S. Peterson, MD, of The Saban Research Institute of Children's Hospital Los Angeles, has found structural differences in the cerebral cortex of patients with depression and that these differences normalize with appropriate medication.

7 Mar 2017

Benefits of compact MRI

The kind of research I'm interested in is a technique called diffusion MRI and this technique is sensitive to the microstructure of the tissue. Particular clinical applications that it is used for are cancer and looking at neurodegenerative diseases.

From Bruker BioSpin Division 3 Mar 2017

Study establishes ENL protein as potential drug target for acute myeloid leukemia

Anyone who uses an employee badge to enter a building may understand how a protein called ENL opens new possibilities for treating acute myeloid leukemia (AML), a fast-growing cancer of bone marrow and blood cells and the second most common type of leukemia in children and adults.

2 Mar 2017

Using Spherical Nucleic Acids to Track and Treat Disease

Spherical nucleic acids are structures that are made by taking a nanoparticle template and using chemistry to arrange short strands of DNA or RNA on the surface of those particles. The spherical core of the nanoparticle creates a spherical arrangement of DNA or RNA, similar to tiny little balls of nucleic acids.

From Pittcon 1 Mar 2017

Study suggests new strategy for treating Alzheimer's disease

Alzheimer's disease (AD) is one of the most common form of dementia. In search for new drugs for AD, the research team, led by Professor Mi Hee Lim of Natural Science at UNIST has developed a metal-based substance that works like a pair of genetic scissors to cut out amyloid-β (Aβ), the hallmark protein of AD.

28 Feb 2017

Scientists develop in vitro stem cell-based bioassay for detecting biological activity of BoNTs

Scientists at the Institute for Infectious Diseases, University of Bern have developed an in vitro stem cell-based bioassay grown on multi-electrode arrays capable of detecting the biological activity of Clostridium botulinum neurotoxins.

28 Feb 2017

SBP researchers identify new regulator of innate immune response to foreign invaders

Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a new regulator of the innate immune response—the immediate, natural immune response to foreign invaders.

28 Feb 2017

New anti-cocaine monoclonal antibody moves forward towards clinical studies in humans

A University of Cincinnati researcher who has developed an immunotherapy to help reverse cocaine addiction that's been successful in animal models says he hopes to have it in clinical trials in human volunteers within a year.

28 Feb 2017

Researchers aim to develop sustained and controllable insulin release system for treatment of diabetes

The prevalence of diabetes has grown around the world over the past three decades. In 2016, the World Health Organization estimated that 422 million people had the disease as the rate of obesity also increased.

27 Feb 2017

Diagnosing Infections Through Molecules in Patient Breath

Over the past couple of decades, the analytical technology and the clinical microbiology insight needed to create a breath test for infections has seen a considerable number of advances and there are now numerous research teams focused on evaluating patient breath as a diagnostic fluid for infectious diseases. Significant challenges still need to be overcome.

From Pittcon 27 Feb 2017

New humanized model enables better characterization of Alzheimer's pathology

Cells behave differently when removed from their environments, just as cells that develop in cultures do not behave like cells in living creatures.

24 Feb 2017

Precise inactivation of neurotransmitter receptors using CALI technique erases fear memory in mice

The delivery of chemical messenger (neurotransmitter) receptors to the junctions between nerve cells (synapses) is crucial to cognitive processes such as memory.

23 Feb 2017

Scientists engineer smallest CRISPR-Cas9 system to date

Scientists at the Center for Genome Engineering, within the Institute for Basic Science0, in collaboration with KIM Eunji and KIM Jeong Hun have engineered the smallest CRISPR-Cas9 to date, delivered it to the muscle cells and in the eyes of mice via adeno-associated viruses and used it to modify a gene causing blindness.

21 Feb 2017

in vivo News and Research

Case studies for the role of in-process particle measurement to complement traditional API dissolution studies

Targeting cancer stem cells may be effective way to prevent spread of squamous cell carcinoma

Drug could activate innate anti-tumor immunity to eradicate aggressive prostate cancer in mice

New approach could regenerate skull bone with better quality and no scar tissue

Study reports presence of structural changes in the brain during medication treatment for depression

Benefits of compact MRI

Study establishes ENL protein as potential drug target for acute myeloid leukemia

Using Spherical Nucleic Acids to Track and Treat Disease

Study suggests new strategy for treating Alzheimer's disease

Scientists develop in vitro stem cell-based bioassay for detecting biological activity of BoNTs

SBP researchers identify new regulator of innate immune response to foreign invaders

New anti-cocaine monoclonal antibody moves forward towards clinical studies in humans

Researchers aim to develop sustained and controllable insulin release system for treatment of diabetes

Diagnosing Infections Through Molecules in Patient Breath

New humanized model enables better characterization of Alzheimer's pathology

Precise inactivation of neurotransmitter receptors using CALI technique erases fear memory in mice

Scientists engineer smallest CRISPR-Cas9 system to date

Researchers develop novel in vivo model for studying pancreatic cancer

New approach could make organometallic catalysis applicable for therapy or diagnostics

Study provides insight into how microRNA may amplify effects of drug treatment in liver cancer

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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