Acute Lymphoblastic Leukemia News and Research

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Acute lymphoblastic leukemia (ALL) is a cancer of the white blood cells, the cells in the body that normally fight infections. There are two main types of white blood cells-lymphoid cells and myeloid cells. ALL affects lymphoid cells.

FDA label update expands CAR T access for primary CNS lymphoma

Dana-Farber Cancer Institute-led research helped drive an FDA label update for axicabtagene ciloleucel (Yescarta) that removes a prior exclusion for patients with primary central nervous system lymphoma, a rare and aggressive lymphoma of the brain and spinal cord.

9 Feb 2026

Genome-edited immune cell therapy shows promise for treating aggressive blood cancer

A groundbreaking new treatment using genome-edited immune cells, developed by scientists at UCL (University College London) and Great Ormond Street Hospital (GOSH), has shown promising results in helping children and adults fight a rare and aggressive form of blood cancer called T-cell acute lymphoblastic leukemia (T-ALL).

8 Dec 2025

Chemotherapy-free combination treatment outperforms traditional regimens in patients with Ph+ ALL

A chemotherapy-free combination treatment outperformed a combination of targeted therapy and chemotherapy among patients with Ph+ acute lymphoblastic leukemia (ALL) in a new study.

7 Dec 2025

Chemotherapy-based conditioning matches outcomes of total body irradiation for MRD-negative B-ALL

In a new trial, patients with B-acute lymphoblastic leukemia (B-ALL) who had no evidence of remaining cancer cells after prior treatment, experienced comparable outcomes whether they received chemotherapy-based conditioning or total body irradiation (TBI), the standard conditioning regimen used before hematopoietic cell transplantation.

7 Dec 2025

Many families of children with leukemia face significant financial hardship during treatment

Nearly a third of families with children receiving chemotherapy for acute lymphoblastic leukemia (ALL) – the most common pediatric cancer – develop serious financial difficulties during their child's treatment, including losing 25% or more of their household income and struggling to cover the costs of basic living expenses such as housing, food, and utilities.

7 Dec 2025

Breakthrough immunotherapy approved for treatment of adults with aggressive blood cancer

Adult patients with an aggressive form of leukemia will be able to receive a breakthrough immunotherapy, which was invented by UCL researchers, on the NHS within weeks following approval for use by the National Institute for Health and Care Excellence (NICE).

27 Nov 2025

Young donor age proves critical for survival after stem cell transplantation

The selection of suitable donors is crucial for the long-term recovery of patients after an allogeneic hematopoietic stem cell transplantation (allo-HSCT).

21 Nov 2025

Targeting aggressive childhood leukemia with nanobody PROTACs

Scientists at the University of Duisburg-Essen are researching new therapies for aggressive forms of childhood leukemia.

13 Oct 2025

IGF2BP3 protein drives leukemia growth by linking metabolism and RNA control

Cancer cells are relentless in their quest to grow and divide, often rewiring their metabolism and modifying RNA to stay one step ahead.

26 Sep 2025

New method reveals how mitochondrial DNA mutations influence cancer growth

Mitochondria act as energy factories in cells and have their own, separate DNA. Mutations to mitochondrial DNA (mtDNA) have been observed in cancer, but it has been unclear how these changes might affect cancer growth.

10 Sep 2025

Pesticide exposure during pregnancy linked to higher death risk in children with leukemia

Public concern continues to grow about the harmful effects of pesticides and other environmental pollutants, especially for children. Pesticides have previously been linked to a higher risk of developing childhood leukemia.

9 Sep 2025

Uncovering the hidden architecture of the genome in three dimensions

In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be helpful for learners to begin with the linear presentation of how stretches of DNA form genes, this oversimplification undersells the significance of the genome's 3D structure.

12 Jul 2025

Planned C-sections linked to increased risk of developing childhood leukemia

Children born by planned C-section have an increased risk of developing acute lymphoblastic leukemia (ALL) later in life.

4 Jul 2025

Timepoint at which B cells transform into leukemic cells impacts treatment outcomes

New findings show that the stage of normal cell development at which B cells transform into leukemic cells impacts treatment outcomes for pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL).

2 Jul 2025

Universal CAR T cell therapy shows promise for aggressive T cell cancers

A new type of immunotherapy that targets aggressive blood cancers shows promising results alongside manageable side effects, according to the results of an international phase 1/2 clinical trial led by researchers at Washington University School of Medicine in St. Louis.

31 May 2025

Combination of two drugs shows promise in treating B-cell acute lymphoblastic leukemia

A combination of two drugs could improve outcomes and reduce the need for toxic chemotherapy for B-cell acute lymphoblastic leukemia (B-ALL), the commonest cancer in childhood and one that can be particularly difficult to treat in older patients, according to Cambridge scientists.

20 May 2025

Acute Lymphoblastic Leukemia News and Research

Further Reading

FDA label update expands CAR T access for primary CNS lymphoma

Genome-edited immune cell therapy shows promise for treating aggressive blood cancer

Chemotherapy-free combination treatment outperforms traditional regimens in patients with Ph+ ALL

Chemotherapy-based conditioning matches outcomes of total body irradiation for MRD-negative B-ALL

Many families of children with leukemia face significant financial hardship during treatment

Breakthrough immunotherapy approved for treatment of adults with aggressive blood cancer

Young donor age proves critical for survival after stem cell transplantation

Targeting aggressive childhood leukemia with nanobody PROTACs

IGF2BP3 protein drives leukemia growth by linking metabolism and RNA control

New method reveals how mitochondrial DNA mutations influence cancer growth

Pesticide exposure during pregnancy linked to higher death risk in children with leukemia

Uncovering the hidden architecture of the genome in three dimensions

Planned C-sections linked to increased risk of developing childhood leukemia

Timepoint at which B cells transform into leukemic cells impacts treatment outcomes

Universal CAR T cell therapy shows promise for aggressive T cell cancers

Combination of two drugs shows promise in treating B-cell acute lymphoblastic leukemia

CAR-T cell therapy linked to brain fog in cancer patients

Novel cancer immunotherapy approach could complement existing CAR-T treatments

Researchers develop TIM-3 decoy to enhance CAR-T therapy effectiveness for B-ALL tumors

UIC scientists redesign asparaginase to minimize leukemia treatment side effects

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