Amyotrophic Lateral Sclerosis News and Research

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New viral model triggers Parkinson's symptoms without using toxins

Scientists usually use animal models when studying Parkinson's disease because these models mimic the disease well.

29 Jun 2026

Discovery of karyoptosis opens new therapeutic targets for Alzheimer's and frontotemporal dementia

Markers of a new mechanism for cell death, called karyoptosis, have been found in brains of patients with Alzheimer's disease and frontotemporal dementia (FTD).

25 Jun 2026

Genetic testing could sharply increase demand for ALS specialist care

The availability of genetic testing for amyotrophic lateral sclerosis (ALS) for people with a family member diagnosed with the disease is expected to greatly increase the number of clinic visits to specialized ALS centers over the next decade, according to a study published June 24, 2026, in Neurology Genetics, an official journal of the American Academy of Neurology.

24 Jun 2026

U-M Health neurosurgeons complete first human implant of wireless brain computer interface

Neurosurgeons at University of Michigan Health completed the first-in-human implant of a Paradromics Inc., wireless brain-computer interface, or BCI, as part of a national clinical trial for patients with difficulty speaking.

17 Jun 2026

Blood proteins reveal which aging cells may raise disease risk

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16 Jun 2026

Blood-based indicator assesses organ age to predict disease risk

The candles on your birthday cake don't tell the whole story. As anyone who ever attended a high-school reunion can tell you, some people age faster than others.

15 Jun 2026

Brain injury survivors face higher risk of brain cancer death

Daniel Daneshvar, MD, PhD, director of the HealthSpan Lab and Chief of the Department of Physical Medicine and Rehabilitation at Mass General Brigham, and Charlotte Luster, of the HealthSpan Lab, are the senior and lead authors of a paper published in Neuroepidemiology, "Brain Cancer Mortality following Traumatic Brain Injury (TBI): A TBI Model Systems Study."

10 Jun 2026

Allen Institute launches global research initiative to accelerate new treatments for brain disorders

The Allen Institute, together with partner organizations, today launched the Brain Health accelerator: an ambitious global research initiative seeking to identify the specific brain cells and circuits affected in neurodegenerative disease and other brain disorders and use that knowledge to accelerate the development of new treatments.

2 Jun 2026

Rice and Baylor join BrainGate to develop brain-computer interfaces for people with paralysis

When a person loses a limb, a prosthesis often can help restore a significant degree of mobility. But when movement or communication is impaired by a neurological condition such as amyotrophic lateral sclerosis (ALS), spinal cord injury or stroke, there are, as of yet, very few options for the affected individual.

28 May 2026

New insights into ALS progression through glial cell behavior

All the core facilities of the Cibio Department of the University of Trento are involved in a study on ALS, co-funded by Fondazione AriSla, national organizations and various donors, to better understand the molecular mechanisms of slow-progressing cases.

5 May 2026

Scientists discover a potential new way to slow ALS disease progression

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes the progressive loss of motor neurons, which in most cases leads to respiratory failure within three to five years after diagnosis.

30 Apr 2026

Scientists seek to reverse neurodegeneration by eliminating harmful RNA pollution

Researchers at University of California San Diego School of Medicine, the Salk Institute and Sanford Burnham Prebys have received a four-year, $13 million award from the California Institute for Regenerative Medicine (CIRM) to investigate how to reverse age-related neurodegeneration by eliminating what the researchers call "RNA pollution" in aging neurons.

27 Apr 2026

How the immune system may influence Alzheimer’s, Parkinson’s, and related diseases

This review argues that neurodegeneration is shaped not only by toxic protein buildup but also by immune signaling, with microglia and T cells able to either protect the brain or worsen damage depending on context. It also highlights aging, head injury, and viral infection as major forces that reshape CNS immunity and may influence disease progression and future treatment strategies.

16 Apr 2026

Study explains failure of cellular cleanup in neurodegenerative diseases

Inside every cell, a cleanup operation runs around the clock. Proteins are constantly damaged by wear and tear. Some can be repaired, while others must be dismantled and recycled.

15 Apr 2026

PRISM ALS: A new global collaboration to expand patient-derived stem cell models and accelerate treatments

A new global initiative launched today aims to close a critical gap in ALS/MND drug discovery - current cell models used for testing treatments do not currently reflect the diverse nature of the disease - that affects both researchers developing therapies and the people urgently waiting for them.

From ALS Therapy Development Institute (ALS TDI) 1 Apr 2026

Investigational oral therapy shows safety and potential benefits in ALS trial

In a phase 2b clinical trial, an investigational oral therapy called PrimeC was found to be safe and well tolerated in people living with amyotrophic lateral sclerosis (ALS), with exploratory findings suggesting target engagement and potential clinical benefits.

16 Mar 2026

New BrainGate iBCI typing neuroprosthesis can restore communication in patients with paralysis

Loss of communication can be among the most devastating symptoms for patients with paralysis. A new study by investigators from Mass General Brigham Neuroscience Institute and Brown University describes an investigational implantable brain computer interface (iBCI) typing neuroprosthesis that can restore communication with speed and accuracy.

16 Mar 2026

New study identifies specific brain cells most vulnerable to ALS and dementia

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) belong to a spectrum of neurodegenerative diseases with overlapping symptoms, characterized by muscle wasting, paralysis, dementia, and other serious impairments.

12 Mar 2026

Novel embedding-driven AI for adaptable brain control

Motor imagery (MI) is the mental process of imagining a specific limb movement, such as raising a hand or walking, without physically performing it. These imagined movements generate distinct patterns of brain activity that can be recorded using electroencephalography (EEG).

11 Mar 2026

Novel lipid bubble delivery shows promise for ALS treatment

A researcher at the University of Missouri has made a promising breakthrough in the quest to help people with amyotrophic lateral sclerosis (ALS), the neurodegenerative disorder commonly known as Lou Gehrig's disease.

26 Feb 2026