Clinical Trial News and Research

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Tick-borne alpha-gal syndrome poses potential risks during blood transfusions

A new multi-institute study led by researchers at Dartmouth Health and Geisel School of Medicine at Dartmouth suggests that alpha-gal syndrome, the tick-borne disease that can result in a chronic allergy to meat and animal byproducts, also may complicate certain patients' ability to safely receive a blood plasma or platelet transfusion.

24 Aug 2026

Japan vaccinated heavily during COVID-19. Why are so many unsure about vaccinating next time?

A nationwide Japanese survey found that only 53.1% of respondents said they would accept vaccination in a hypothetical future pandemic with COVID-19-like fatality, despite substantially higher previous COVID-19 vaccine uptake. Willingness varied by demographics, perceived disease risk, exposure to misinformation, vaccine characteristics, and practical factors such as cost, evidence, professional recommendations, and accessibility.

24 Aug 2026

New study makes progress in understanding the mechanisms behind severity of HFpEF

Approximately 3 million people in the United States are living with a condition called heart failure with preserved ejection fraction, or HFpEF.

24 Aug 2026

Multi-target interventions may yield superior outcomes for chronic ankle instability

Ankle sprain is the most prevalent sports-related injury affecting the lower limbs, and up to 70% of individuals with ankle sprain experience persistent symptoms, such as sensorimotor impairment and balance deficits, which may ultimately progress to chronic ankle instability (CAI).

24 Aug 2026

A two-year diet trial challenges the idea that weight loss is the only result that matters

In the two-year DELISH randomized trial, adults with obesity achieved modest, sustained weight loss with either an adapted Mediterranean-style program or a commercial weight loss program. The Mediterranean-style intervention produced greater improvements in self-reported diet quality, while 24-month weight loss did not materially differ between groups.

24 Aug 2026

Study highlights strengths and barriers of remote heart failure care

Interviews with patients hospitalized for heart failure, caregivers, providers, and organizational leaders highlighted several strengths of Mighty Heart (a major clinical trial examining the effectiveness of in home and telehealth-enabled visits from paramedics) that may support its adoption and implementation across health systems, a Columbia Nursing-led study finds.

21 Aug 2026

Study provides a more nuanced picture of biological mechanisms linked to autism

How does autism manifest in the brain? Researchers from the University of Southern Denmark and Odense University Hospital have investigated this question in a new study involving 60 adults.

21 Aug 2026

Younger mismatched donors offer new hope for blood cancer patients

Blood cancer patients who cannot find a closely matched stem cell donor may have more transplant options than previously thought.

21 Aug 2026

Digital program reduces anxiety and depression in adults with chronic medical conditions

A digital program combining guided movement, breathing and meditation exercises, and coping-skills training reduced anxiety and depression symptoms in adults with chronic medical conditions, according to a new study published August 20th in the open access journal PLOS Medicine by Puneeta Tandon of the University of Alberta, Canada, and colleagues.

20 Aug 2026

Only three of 1,357 FDA-cleared AI devices tested patient outcomes

Researchers found that among 1,357 FDA-cleared or approved AI/ML-enabled medical devices, only 34 were linked to registered clinical trials and just three had been evaluated for patient-centered outcomes. The study highlights major gaps in prospective testing, demographic representation, transparency, and evidence showing whether medical AI meaningfully improves patients’ health.

20 Aug 2026

Federal and industry sponsors play complementary roles in cancer clinical trials

A comparative study of the cancer clinical trial portfolios supported by federal funding versus industry funding reveals they have distinct, interdependent roles in cancer research.

20 Aug 2026

Brain organoid studies on the ISS move closer to new treatments

Research using human brain organoids onboard the International Space Station International Space Station (ISS) helped lead to the clinical trial of a potential therapy for Rett syndrome, a debilitating neurological disorder in children.

20 Aug 2026

Intravenous iron before heart surgery cuts transfusion needs

Giving intravenous iron to patients with anemia before heart surgery reduces the need for a red blood transfusion and results in an extra day at home in the first 90 days after surgery, finds a clinical trial published by The BMJ today.

19 Aug 2026

Special journal issue highlights precision prevention in cancer epidemiology

Cancer epidemiology is not merely about counting cases; it is a dynamic field that informs screening policies, resource allocation, and clinical trial design.

19 Aug 2026

Real-world study shows Oregon psilocybin services relieve mental health symptoms

People participating in an Oregon Health & Science University-led study of state-regulated psilocybin services reported relief from symptoms of anxiety, depression and post-traumatic stress disorder - with almost two-thirds declaring the experience to be among the most meaningful of their life.

19 Aug 2026

Prenatal strength training may help reduce the risk of gestational diabetes

Various forms of physical exercise may help prevent diabetes during pregnancy (or gestational diabetes), but data are limited. In a randomized clinical trial published in Acta Obstetricia et Gynecologica Scandinavica including 209 pregnant women, participants who followed a strength training program from gestational weeks 12–14 until week 36 or delivery had lower rates of gestational diabetes.

19 Aug 2026

Qureight expands with addition of second site, to accommodate rapid growth and ongoing development of chest Foundation Model

Qureight, an end-to-end imaging company that provides enterprise-grade imaging and precision endpoints for clinical trials with a focus on lung and heart disease, today announced the opening of its new office space in London, UK.

From Qureight 19 Aug 2026

Health visitor support helps mothers stay smoke-free after childbirth

Women who receive health visitor support alongside smoking relapse prevention advice are more likely to remain smoke-free after childbirth, according to University of East Anglia (UEA) research.

18 Aug 2026

Habitual pork consumption supports clinically meaningful weight loss, study finds

According to a peer-reviewed study published May 29, 2026 in Nutrition & Diabetes, adults with overweight or obesity (mean BMI: 33.6 kg/m²; mean age: 47.7 years) who reported continuing to eat pork while participating in a 6-month digital weight management program lost a clinically significant 5.3% of starting body weight and improved their overall diet quality scores by 4.3 points.

18 Aug 2026

Alliance highlights the importance of clinical research on World Breast Cancer Research Day

This World Breast Cancer Research Day, the Alliance for Clinical Trials in Oncology is highlighting the importance of clinical research in advancing better treatments and improving early detection to ultimately help prevent and cure breast cancer.

18 Aug 2026

Clinical Trial News and Research

Tick-borne alpha-gal syndrome poses potential risks during blood transfusions

Japan vaccinated heavily during COVID-19. Why are so many unsure about vaccinating next time?

New study makes progress in understanding the mechanisms behind severity of HFpEF

Multi-target interventions may yield superior outcomes for chronic ankle instability

A two-year diet trial challenges the idea that weight loss is the only result that matters

Study highlights strengths and barriers of remote heart failure care

Study provides a more nuanced picture of biological mechanisms linked to autism

Younger mismatched donors offer new hope for blood cancer patients

Digital program reduces anxiety and depression in adults with chronic medical conditions

Only three of 1,357 FDA-cleared AI devices tested patient outcomes

Federal and industry sponsors play complementary roles in cancer clinical trials

Brain organoid studies on the ISS move closer to new treatments

Intravenous iron before heart surgery cuts transfusion needs

Special journal issue highlights precision prevention in cancer epidemiology

Real-world study shows Oregon psilocybin services relieve mental health symptoms

Prenatal strength training may help reduce the risk of gestational diabetes

Qureight expands with addition of second site, to accommodate rapid growth and ongoing development of chest Foundation Model

Health visitor support helps mothers stay smoke-free after childbirth

Habitual pork consumption supports clinically meaningful weight loss, study finds

Alliance highlights the importance of clinical research on World Breast Cancer Research Day

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